Correction to: Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology

Background: Abnormally hyperphosphorylated tau is a defining pathological feature of tauopathies, such as Alzheimer’s disease (AD), and accumulating evidence suggests a role for iron in mediating tau pathology that may lead to cognitive decline in these conditions. The metal chelator deferiprone (DFP), which has a high affinity for iron, is currently in clinical trials for AD and Parkinson’s disease. However, the effect of DFP on tau pathology remains underexplored. Objective: We aimed to investigate the impact of chronic DFP treatment on tau pathology using a well-characterized mouse model of tauopathy (rTg(tauP301L)4510). Methods: Animals were treated daily with DFP (100 mg/kg) via oral gavage for 16 weeks. After 14 weeks, mice were tested in the Y-maze, open field, Morris water maze, and rotorod. At the end of the study, brain tissue was collected to examine metal levels (using inductively coupled plasma-mass spectrometry) and for western blot analysis of DFP on tau and iron associated pathways. Results: DFP significantly reduced anxiety-like behavior, and revealed a trend toward improved cognitive function. This was accompanied by a decrease in brain iron levels and sarkosyl-insoluble tau. Our data also showed downregulation of the tau kinases glycogen synthase kinase 3β and cyclin dependent kinase-5 in DFP treated mice and an increase in the methylation of the catalytic subunit of protein phosphatase 2A. Conclusion: These data support the hypothesis that suggests that iron plays a neurotoxic role in tauopathies and may be a potential therapeutic target for this class of disorders.

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Sex differences in spatial and non-spatial Y-maze performance after chronic stress

Neurobiology of Learning and Memory ◽

10.1016/s1074-7427(02)00018-7 ◽

2003 ◽

Vol 79 (1) ◽

pp. 32-40 ◽

Cited By ~ 140

Author(s):

Cheryl D Conrad ◽

Katherine A Grote ◽

Rebecca J Hobbs ◽

Angelique Ferayorni

Keyword(s):

Sex Differences ◽

Chronic Stress ◽

Maze Performance ◽

Y Maze

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The Impairment of Spatial Memory Following Low-Level Sarin Inhalation Exposure and Antidotal Treatment in Rats

Acta Medica (Hradec Kralove Czech Republic) ◽

10.14712/18059694.2019.72 ◽

2002 ◽

Vol 45 (4) ◽

pp. 149-153 ◽

Cited By ~ 6

Author(s):

Jiří Kassa ◽

Gabriela Krejčová ◽

Josef Vachek

Keyword(s):

Spatial Memory ◽

Cognitive Functions ◽

Inhalation Exposure ◽

Maze Performance ◽

Memory Impairments ◽

Low Level ◽

Y Maze ◽

Level 1 ◽

And Control ◽

Level 2

1. To study the influence of antidotes on low-level sarin-induced impairment of cognitive functions, the rats were exposed to three various low concentrations of sarin (LEVEL 1–3) for 60 minutes in the inhalation chamber. In addition, one group of rats was exposed to LEVEL 2 of sarin repeatedly. 2. Testing of cognitive functions was carried out using the Y-maze evaluating learning and spatial memory. The correct averse behavior of sarin-exposed rats in the Y-maze was tested several times within four weeks following sarin inhalation exposure and antidotal treatment to look for any cognitive impairments. 3. The results were compared to the Y-maze performance of sarin-exposed rats without antidotal treatment and control rats exposed to pure air instead of sarin with or without antidotal treatment. While antidotal treatment was able to eliminate a short-term deficiency in the Y-maze performance in rats exposed to the LEVEL 1 of sarin, a significant decrease in the Y-maze performance in rats exposed to sarin at the LEVEL 2 and 3 was only shortened. Sarin-induced spatial memory impairments in rats exposed repeatedly to sarin at the LEVEL 2 was also shortened when rats were treated following each sarin inhalation exposure. 4. The findings confirm that antidotes currently used for nerve agent poisonings are beneficial for the treatment of rats singly or repeatedly exposed to non-convulsive symptomatic or even clinically asymptomatic concentrations of sarin.

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Experimental Hypothyroidism Delays Field Excitatory Post-Synaptic Potentials and Disrupts Hippocampal Long-term Potentiation in the Dentate Gyrus of Hippocampal Formation and Y-Maze Performance in Adult Rats

Journal of Neuroendocrinology ◽

10.1111/j.1365-2826.2011.02253.x ◽

2012 ◽

Vol 24 (3) ◽

pp. 422-433 ◽

Cited By ~ 24

Author(s):

A. S. Artis ◽

S. Bitiktas ◽

E. Taşkın ◽

N. Dolu ◽

N. Liman ◽

...

Keyword(s):

Dentate Gyrus ◽

Hippocampal Formation ◽

Long Term Potentiation ◽

Maze Performance ◽

Adult Rats ◽

Synaptic Potentials ◽

Y Maze ◽

Term Potentiation

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Influence of Amount of Reward in a Complex Learning Situation

Psychological Reports ◽

10.2466/pr0.1964.14.2.427 ◽

1964 ◽

Vol 14 (2) ◽

pp. 427-432 ◽

Cited By ~ 3

Author(s):

Henry A. Cross ◽

William N. Boyer

Keyword(s):

Straight Alley ◽

Maze Performance ◽

Learning Situation ◽

Complex Learning ◽

Y Maze ◽

Reward Amount ◽

Maze Problem

28 hooded rats received 4 pellets of food for every run in a 4-unit multiple-Y maze, while 25 others received 1 pellet. Prior to the maze problem, Ss had received different reward experiences in a straight alley as follows: some had always received 4 pellets, some always 1 pellet, some had received mixed reward amounts, and some had no previous reward experience. Y-maze performance was not reliably related to the previous reward experience in the linear maze, and further research is needed before it will be possible to assess the influence of previous reward experience on contemporary learning. Errors and speed measures in the Y maze were influenced by contemporary reward amount.

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