Pathology, tissue tropism and antibody response of nephropathogenic infectious bronchitis virus (IBV) Indian isolate in experimentally infected chicken

VirusDisease ◽  
2021 ◽  
Author(s):  
T. R. Kannaki ◽  
J. Venkatesh Yadav ◽  
E. Priyanka ◽  
M. Lakshman
Keyword(s):  
Antibody Response ◽  
Infectious Bronchitis Virus ◽  
Indian Isolate ◽  
Tissue Tropism ◽  
Infected Chicken ◽  
Infectious Bronchitis

scholarly journals Pathogenicity and tissue tropism of infectious bronchitis virus is associated with elevated apoptosis and innate immune responses

Virology ◽  
2016 ◽  
Vol 488 ◽  
pp. 232-241 ◽  
Author(s):  
Rajesh Chhabra ◽  
Suresh V Kuchipudi ◽  
Julian Chantrey ◽  
Kannan Ganapathy
Keyword(s):  
Immune Responses ◽  
Infectious Bronchitis Virus ◽  
Innate Immune ◽  
Tissue Tropism ◽  
Innate Immune Responses ◽  
Infectious Bronchitis

scholarly journals A highly pathogenic GI-19 lineage infectious bronchitis virus originated from multiple recombination events with broad tissue tropism

2020 ◽  
Vol 285 ◽  
pp. 198002 ◽  
Author(s):  
Yutong Hou ◽  
Lili Zhang ◽  
Mengting Ren ◽  
Zongxi Han ◽  
Junfeng Sun ◽  
...  
Keyword(s):  
Infectious Bronchitis Virus ◽  
Tissue Tropism ◽  
Highly Pathogenic ◽  
Infectious Bronchitis ◽  
Multiple Recombination

scholarly journals Carbonized Lysine-Nanogels Protect against Infectious Bronchitis Virus

2021 ◽  
Vol 22 (11) ◽  
pp. 5415
Author(s):  
Ding-Li Chou ◽  
Ju-Yi Mao ◽  
Anisha Anand ◽  
Han-Jia Lin ◽  
John Han-You Lin ◽  
...  
Keyword(s):  
Infectious Bronchitis Virus ◽  
Pseudorabies Virus ◽  
Hatching Rate ◽  
Viral Inhibition ◽  
Infected Chicken ◽  
In Ovo ◽  
Chicken Embryos ◽  
Virus Attachment ◽  
Infectious Bronchitis

In this study, we demonstrate the synthesis of carbonized nanogels (CNGs) from an amino acid (lysine hydrochloride) using a simple pyrolysis method, resulting in effective viral inhibition properties against infectious bronchitis virus (IBV). The viral inhibition of CNGs was studied using both in vitro (bovine ephemeral fever virus (BEFV) and pseudorabies virus (PRV)) and in ovo (IBV) models, which indicated that the CNGs were able to prevent virus attachment on the cell membrane and penetration into the cell. A very low concentration of 30 μg mL−1 was found to be effective (>98% inhibition) in IBV-infected chicken embryos. The hatching rate and pathology of IBV-infected chicken embryos were greatly improved in the presence of CNGs. CNGs with distinctive virus-neutralizing activities show great potential as a virostatic agent to prevent the spread of avian viruses and to alleviate the pathology of infected avian species.

scholarly journals Molecular Characterization of 4/91 Infectious Bronchitis Virus Leading to Studies of Pathogenesis and Host Responses in Laying Hens

Pathogens ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 624
Author(s):  
Shahnas M. Najimudeen ◽  
Mohamed S. H. Hassan ◽  
Dayna Goldsmith ◽  
Davor Ojkic ◽  
Susan C. Cork ◽  
...  
Keyword(s):  
Antibody Response ◽  
Infectious Bronchitis Virus ◽  
Egg Production ◽  
Immune Cell ◽  
Laying Hens ◽  
Standard Dose ◽  
Serum Antibody ◽  
T Cell Subsets ◽  
Eastern Canada ◽  
Infectious Bronchitis

Infectious bronchitis virus (IBV) initially establishes the infection in the respiratory tract and then spreads to other tissues depending on its virulence. During 2011–2018, the 4/91 IBV strain was isolated from poultry flocks affected by decreased egg production and quality in Eastern Canada. One of the Canadian 4/91 IBV isolates, IBV/Ck/Can/17-038913, was propagated in embryonated chicken eggs and molecularly characterized using whole genome sequencing. An in vivo study in laying hens was conducted to observe if IBV/Ck/Can/17-038913 isolate affects the egg production and quality. Hens were infected with IBV/Ck/Can/17-038913 isolate during the peak of egg lay, using a standard dose and routes maintaining uninfected controls. Oropharyngeal and cloacal swabs were collected at predetermined time points for the quantification of IBV genome loads. At 6 and 10 days post-infection, hens were euthanized to observe the lesions in various organs and collect blood and tissue samples for the quantification of antibody response and IBV genome loads, respectively. Egg production was not impacted during the first 10 days following infection. No gross lesions were observed in the tissues of the infected birds. The IBV genome was quantified in swabs, trachea, lung, proventriculus, cecal tonsils, kidney, and reproductive tissues. The serum antibody response against IBV was quantified in infected hens. In addition, histological changes, and recruitment of immune cells, such as macrophages and T cell subsets in kidney tissues, were measured. Overall, data show that IBV/Ck/Can/17-038913 isolate is not associated with egg production issues in laying hens infected at the peak of lay, while it demonstrates various tissue tropism, including kidney, where histopathological lesions and immune cell recruitments were evident.

Comparative Use of Direct Organ Cultures of Infected Chicken Tracheas in Isolating Avian Infectious Bronchitis Virus

1985 ◽  
Vol 29 (2) ◽  
pp. 546 ◽  
Author(s):  
K. Sawaguchi ◽  
S. Yachida ◽  
S. Aoyama ◽  
N. Takahashi ◽  
Y. Iritani ◽  
...  
Keyword(s):  
Infectious Bronchitis Virus ◽  
Avian Infectious Bronchitis Virus ◽  
Infected Chicken ◽  
Organ Cultures ◽  
Infectious Bronchitis
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