Survey of urinary albumin level and estimated GFR in Japanese patients with type 2 diabetes mellitus

Previous studies have reported that diabetic kidney disease is associated with cardiovascular events and death. Little is known about the independent association of albuminuria and estimated glomerular filtration rate (eGFR), with mortality in Asian patients with type 2 diabetes mellitus (T2DM) without renal failure. We conducted a historical cohort study to clarify this issue in Japanese patients with T2DM. In this study, we recruited 385 patients with T2DM, who never had chronic renal failure (eGFR < 30 mL/min/1.73 m2 at baseline) and malignant diseases. With the end point of all-cause mortality, Cox regression analysis was performed. During the observational period of 7 years, 54 patients died. Cox regression analysis adjusted for confounding factors such as age, duration of diabetes, body mass index, and HbA1c, and showed that urinary albumin level was significantly associated with the mortality [hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.03–1.70 per standard deviation (SD) increase, p = 0.031]. After additional adjustment for eGFR, the association remained significant (HR = 1.32, 95% CI = 1.02–1.70 per SD increase, p = 0.033). On the other hand, eGFR was not associated with the mortality. The present study showed that higher urinary albumin was associated with increased all-cause mortality in T2DM, independently of eGFR. These findings suggest that, regardless of eGFR, albuminuria is important for the increased risk of mortality in Japanese T2DM patients without chronic renal failure (eGFR < 30 mL/min/1.73 m2). However, because of several limitations, further large-scale longitudinal studies are necessary to confirm the present study.

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CORRELATION OF HbA1C WITH MICROALBUMINURIA IN TYPE-2 DIABETES MELLITUS PATIENTS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i4.200 ◽

2019 ◽

Vol 3 (4) ◽

Author(s):

Dr. Anil Kumar ◽

Dr. Neha ◽

Dr. Madhuri Meena ◽

Dr. Y. K. Sanadhya

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycosylated Hemoglobin ◽

Albumin Level ◽

Urinary Albumin ◽

P Value ◽

Common Disease ◽

Care Hospital

Background: Diabetes is a very common disease now a days . It has adverse effect on many human organs as its duration increases. Many studies exist to show its bad effects on body organs in different parts of world. We have studied is there any relation between microalbuminuria with HbA1c levels. Methods: we have done a cross sectional study from January 2016 to March 2017 in a tertiary health care hospital located in Jhalawar, Rajasthan. Our study includes all the known case of type 2 diabetes mellitus patients of age group of 45 years and above. Results: Total 69 patients had Urinary albumin level less than 30 mg/dl out of which Hb1Ac was less than 6.5% present in 20.2% of patients and 79.7% of patients had more than 6.5%. Total 31 patients had Urinary albumin level more than 30 mg/dl out of which only 3% had Hb1Ac value less than 6.5 % whereas 96% had Hb1Ac value more than 6.5%. This association was found to be clinically significant (Pearson Chi-Square- 4.888, df is 1 and p value is 0.027, Fishers Exact test is 0.033) Conclusion: Patients having microalbuminuria were associated with high level of glycosylated haemoglobin. Keywords: Diabetes Mellitus, Microalbuminuria, Glycosylated Hemoglobin.

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Abstract #212 Association of Serum Insulin and Urinary Albumin with Occult Coronary Artery Disease in Patients with Type-2 Diabetes Mellitus

Endocrine Practice ◽

10.1016/s1530-891x(20)47058-2 ◽

2018 ◽

Vol 24 ◽

pp. 33-34

Author(s):

Sudhir Bhandari ◽

Senior ◽

Banshi Saboo ◽

Shashank Joshi

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Type 2 Diabetes Mellitus ◽

Coronary Artery ◽

Serum Insulin ◽

Urinary Albumin ◽

Artery Disease

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Large-Scale Cross-Sectional Study of the Problem Areas in Diabetes Survey among Japanese Patients with Type 2 Diabetes Mellitus

Diabetes ◽

10.2337/db18-2393-pub ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 2393-PUB

Author(s):

KENICHIRO TAKAHASHI ◽

MINORI SHINODA ◽

RIKA SAKAMOTO ◽

JUN SUZUKI ◽

TADASHI YAMAKAWA ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Large Scale ◽

Japanese Patients ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Diabetes Survey

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Faculty Opinions recommendation of A randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus and diabetic nephropathy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727146123.793527044 ◽

2017 ◽

Author(s):

Luis Ruilope ◽

Enrique Morales

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Japanese Patients ◽

Randomized Controlled Study ◽

Controlled Study ◽

Randomized Controlled

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Comparative effects of insulin glulisine and lispro on postprandial plasma glucose and lipid profile in Japanese patients with type 2 diabetes mellitus

Diabetology International ◽

10.1007/s13340-020-00475-1 ◽

2020 ◽

Author(s):

Mika Yamada ◽

Jinya Suzuki ◽

Takahiro Nakaya ◽

Mai Ichikawa ◽

Katsushi Yamamoto ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Profile ◽

Plasma Glucose ◽

Japanese Patients ◽

Postprandial Plasma Glucose ◽

Insulin Glulisine

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Treatment patterns, persistence and adherence rates in patients with type 2 diabetes mellitus in Japan: a claims-based cohort study

BMJ Open ◽

10.1136/bmjopen-2018-025806 ◽

2019 ◽

Vol 9 (3) ◽

pp. e025806 ◽

Cited By ~ 21

Author(s):

Rimei Nishimura ◽

Haruka Kato ◽

Koichi Kisanuki ◽

Akinori Oh ◽

Shinzo Hiroi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Drug Class ◽

Japanese Patients ◽

Medical Data ◽

Treatment Patterns ◽

Administrative Claims ◽

Antidiabetic Drug

ObjectiveTo determine real-world trends in antidiabetic drug use, and persistence and adherence, in Japanese patients with type 2 diabetes mellitus (T2DM).DesignRetrospective evaluation of administrative claims data (2011–2015) using the Japan Medical Data Center (JMDC) and Medical Data Vision (MDV) databases.SettingAnalysis of two administrative claims databases for Japanese patients with T2DM.ParticipantsAdults (aged ≥18 years) with an International Classification of Diseases, 10th Revision code of T2DM and at least one antidiabetic drug prescription.Main outcome measuresTreatment patterns in untreated (UT) or previously treated (PT) patients receiving antidiabetic therapy; persistence with treatment at 12 months; adherence to treatment at 12 months.Results40 908 and 90 421 patients were included from the JMDC and MDV databases, respectively. The most frequently prescribed therapy at the index (first prescription) date was dipeptidyl peptidase-4 inhibitor (DPP-4i) in UT patients (JMDC: 44.0%, MDV: 54.8%) and combination therapy in PT patients (74.6%, 81.1%). Most common combinations were DPP-4i plus: biguanide (BG; 11.4%, 10.9%), sulfonylurea (SU; 8.4%, 11.0%) or BG+SU (7.8%, 9.1%). In UT or PT patients from either database whose index prescription was for any antidiabetic drug class(es) other than DPP-4i, the most frequent add-on or switch was to DPP-4i. 12-month persistence with index monotherapy was highest with DPP-4i and BG. Adherence was high (≥80%) for all monotherapy schedules, except insulin and glucagon-like peptide-1 agonist, and for the five most frequent two-drug and three-drug combinations. Persistence was greater in elderly UT patients and in those receiving ≤5 medications, but comparatively worse in UT patients with ≥3 index antidiabetic drug classes.ConclusionsThe findings indicate that DPP-4i is the most commonly used antidiabetic drug class in Japanese patients with T2DM, and persistence and adherence to this antidiabetic drug class are high.

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