A case of α-chain variant hemoglobin (Hb Chad) with falsely high HbA1c levels measured by immunoassay

2021 ◽  
Author(s):  
Kei Yoshino ◽  
Yushi Hirota ◽  
Wataru Ogawa ◽  
Kenji Sugawara ◽  
Akira Kawaguchi ◽  
...  
Keyword(s):  
Variant Hemoglobin ◽  
High Hba1c ◽  
Α Chain ◽  
Chain Variant ◽  
Hba1c Levels

Interaction of the β chain variant hemoglobin leslie and the α chain variant hemoglobin montgomery in a black female

1980 ◽  
Vol 8 (2) ◽  
pp. 139-147 ◽  
Author(s):  
T. H. J. Huisman ◽  
M. E. Gravely ◽  
J. B. Wilson ◽  
B. Webber ◽  
A. E. Felice ◽  
...  
Keyword(s):  
Black Female ◽  
Variant Hemoglobin ◽  
Α Chain ◽  
Β Chain ◽  
Chain Variant

scholarly journals Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population

2020 ◽  
Vol 21 (21) ◽  
pp. 8306 ◽  
Author(s):  
Sho Osonoi ◽  
Hiroki Mizukami ◽  
Chieko Itabashi ◽  
Kanichiro Wada ◽  
Kazuhiro Kudoh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Japanese Population ◽  
Pain Threshold ◽  
Hematological Parameters ◽  
Population Based ◽  
Pain Sensation ◽  
Tendon Reflex ◽  
High Hba1c ◽  
Clinical Measures ◽  
Hba1c Levels

Normal-high HbA1c levels are a risk factor for attenuated pain sensation in normoglycemic subjects. It is unclear, however, what mechanisms underlie the pathogenesis of attenuated pain sensation in such a population. We, therefore, explored the relationship between oxidative stress (OS) and pain sensation in a rural Japanese population. A population-based study of 894 individuals (average age 53.8 ± 0.5 years) and 55 subjects with impaired fasting glucose (IFG) were enrolled in this study. Individuals with diabetes were excluded. Relationships between pain threshold induced by intraepidermal electrical stimulation (PINT) and clinico-hematological parameters associated with OS were evaluated. Univariate linear regression analyses revealed age, BMI, HbA1c, the OS biomarker urine 8-hydroxy-2′-deoxyguanosine (8-OHdG), systolic blood pressure, and decreased Achilles tendon reflex on the PINT scores. Adjustments for age, gender, and multiple clinical measures confirmed a positive correlation between PINT scores and urine 8-OHdG (β = 0.09, p < 0.01). Urine 8-OHdG correlated positively with higher HbA1c levels and age in the normoglycemic population. Unlike in the normoglycemic population, both inflammation and OS were correlated with elevated PINT scores in IFG subjects. OS may be a major contributing factor to elevated PINT scores in a healthy Japanese population.

scholarly journals Study of High Performance Liquid Chromatography and Turbidimetric Inhibition Immunoassay for HbA1c Analysis in Diabetic Patients with Variant Hemoglobin

2018 ◽  
Vol 8 (2) ◽  
pp. 114-117
Author(s):  
Gazi Sharmin Sultana ◽  
Nadia Zebin Khan ◽  
Zannat E Khuda ◽  
Tanvira Afroze Sultana ◽  
Tashmim Farhana Dipta ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Glycemic Control ◽  
High Performance ◽  
Hplc Method ◽  
Diabetic Patients ◽  
Genetic Changes ◽  
Variant Hemoglobin ◽  
Hemoglobin Variants ◽  
Hba1c Levels

Background: HbA1c is considered as “gold standard” to evaluate glycemic control in patients with diabetes. Hemoglobin variants are mutant forms of hemoglobin that can occur by genetic changes in specific amino acid that can affect the accuracy of HbA1c measurements. High performance liquid chromatography (HPLC) is the standard method for HbA1c but inaccurate HbA1c values can occur when hemoglobin variants are present in diabetic patient. The aim of our study is to see Turbidimetric Inhibition Immunoassay (TINIA) method can report HbA1c values in diabetic patients with variant hemoglobin when the values are inaccurate on HPLC.Methods: 7590 diabetic patients were analyzed for HbA1c by HPLC method from BIRDEM General Hospital during December 2013 to January 2014. HbA1c levels were again measured by TINIA method in 50 cases out of 7590 who showed either undetectable / below normal HbA1c levels. Hb electrophoresis confirmed the variant hemoglobin in few casesResults: 50 cases out of 7590 (0.65%) had either undetectable / below normal HbA1c levels by HPLC method. Males-26 and females-24; and the ratio was 0.92:1. In 27 cases, HbA1c values were undetectable by HPLC method but in the reportable range by TINIA method. In the other 23 cases, HbA1c levels were below the reportable range (<4%) by HPLC method but were in the normal or higher range by TINIA method. On Bland Altman plot, TINIA method did not agree with HPLC method in variant cases.Conclusion: In South East Asia where Hb variant is high, Low or undetectable HbA1c level by HPLC may be a convenient clue for screening of hemoglobinopathies especially among diabetic population in Bangladesh. All laboratories should have alternative method of HbA1c testing like TINIA along with HPLC for correct determination of glycemic control in variant casesBirdem Med J 2018; 8(2): 114-117

3 cases of variant hemoglobin Hb A2-Niigata detected by falsely high HbA1c values

2020 ◽  
Vol 510 ◽  
pp. 656-658
Author(s):  
Mika Ito ◽  
Kou Sano ◽  
Masafumi Koga
Keyword(s):  
Variant Hemoglobin ◽  
High Hba1c

Hemoglobin Etobicoke: α84(F5) serine replaced by arginine

1969 ◽  
Vol 47 (2) ◽  
pp. 143-146 ◽  
Author(s):  
J. H. Crookston ◽  
Helen A. Farquharson ◽  
D. Beale ◽  
H. Lehmann
Keyword(s):  
Inclusion Body ◽  
Northern Irish ◽  
Hemoglobin Variant ◽  
Variant Hemoglobin ◽  
Hemoglobin A ◽  
Α Chain

In a Canadian family of northern Irish origin, a new hemoglobin variant, hemoglobin Etobicoke, was observed. It differs from hemoglobin A by having a residue of arginine in place of serine in position 84 of the α-chain (helical notation F5). This hemoglobin is slightly less stable than hemoglobin A, but it does not cause an inclusion body anemia.

HB Kurosaki [α7(A5)LYS→GLU]: A New α Chain Variant Found in a Japanese Woman

Hemoglobin ◽  
1995 ◽  
Vol 19 (3-4) ◽  
pp. 197-201 ◽  
Author(s):  
T. Harano ◽  
K. Harano ◽  
K. Imai ◽  
T. Murakami ◽  
H. Matsubara
Keyword(s):  
Japanese Woman ◽  
Α Chain ◽  
Chain Variant

The silent hemoglobin α chain variant Hb Riccarton [α51(CE9)Gly→Ser] may affect HbA1c determination on the HLC-723 G7 analyzer

2008 ◽  
Vol 46 (6) ◽  
Author(s):  
Johannes M.W. van den Ouweland ◽  
Henny van Daal ◽  
Corné H. Klaassen ◽  
Yvonne van Aarssen ◽  
Cornelis L. Harteveld ◽  
...  
Keyword(s):  
Α Chain ◽  
Chain Variant

A new α chain variant Hb Sallanches [α2 104(G11) Cys→Tyr] associated with HbH disease in one homozygous patient

1995 ◽  
Vol 91 (3) ◽  
pp. 608-611 ◽  
Author(s):  
F. Morlé ◽  
A. Francina ◽  
R. Ducrocq ◽  
H. Wajcman ◽  
C. Gonnet ◽  
...  
Keyword(s):  
Α Chain ◽  
Homozygous Patient ◽  
Hbh Disease ◽  
Chain Variant
Sign in / Sign up

Export Citation Format

Share Document