scholarly journals Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population

2020 ◽  
Vol 21 (21) ◽  
pp. 8306 ◽  
Author(s):  
Sho Osonoi ◽  
Hiroki Mizukami ◽  
Chieko Itabashi ◽  
Kanichiro Wada ◽  
Kazuhiro Kudoh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Japanese Population ◽  
Pain Threshold ◽  
Hematological Parameters ◽  
Population Based ◽  
Pain Sensation ◽  
Tendon Reflex ◽  
High Hba1c ◽  
Clinical Measures ◽  
Hba1c Levels

Normal-high HbA1c levels are a risk factor for attenuated pain sensation in normoglycemic subjects. It is unclear, however, what mechanisms underlie the pathogenesis of attenuated pain sensation in such a population. We, therefore, explored the relationship between oxidative stress (OS) and pain sensation in a rural Japanese population. A population-based study of 894 individuals (average age 53.8 ± 0.5 years) and 55 subjects with impaired fasting glucose (IFG) were enrolled in this study. Individuals with diabetes were excluded. Relationships between pain threshold induced by intraepidermal electrical stimulation (PINT) and clinico-hematological parameters associated with OS were evaluated. Univariate linear regression analyses revealed age, BMI, HbA1c, the OS biomarker urine 8-hydroxy-2′-deoxyguanosine (8-OHdG), systolic blood pressure, and decreased Achilles tendon reflex on the PINT scores. Adjustments for age, gender, and multiple clinical measures confirmed a positive correlation between PINT scores and urine 8-OHdG (β = 0.09, p < 0.01). Urine 8-OHdG correlated positively with higher HbA1c levels and age in the normoglycemic population. Unlike in the normoglycemic population, both inflammation and OS were correlated with elevated PINT scores in IFG subjects. OS may be a major contributing factor to elevated PINT scores in a healthy Japanese population.

scholarly journals Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population

2019 ◽  
Vol 10 ◽  
Author(s):  
Chieko Itabashi ◽  
Hiroki Mizukami ◽  
Sho Osonoi ◽  
Kazuhisa Takahashi ◽  
Kazuhiro Kudo ◽  
...  
Keyword(s):  
Risk Factor ◽  
Japanese Population ◽  
Pain Threshold ◽  
High Hba1c

scholarly journals Corrigendum: Normal High HbA1c a Risk Factor for Abnormal Pain Threshold in the Japanese Population

2020 ◽  
Vol 11 ◽  
Author(s):  
Chieko Itabashi ◽  
Hiroki Mizukami ◽  
Sho Osonoi ◽  
Kazuhisa Takahashi ◽  
Kazuhiro Kudo ◽  
...  
Keyword(s):  
Risk Factor ◽  
Japanese Population ◽  
Pain Threshold ◽  
High Hba1c

scholarly journals Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population

2020 ◽  
Vol 8 (1) ◽  
pp. e001739 ◽  
Author(s):  
Kazuhiro Kudoh ◽  
Hiroki Mizukami ◽  
Chieko Itabashi ◽  
Nobuo Fuke ◽  
Sho Osonoi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Clinical Data ◽  
Japanese Population ◽  
Pain Threshold ◽  
Binding Protein ◽  
Oxidative Stress Marker ◽  
Lipopolysaccharide Binding Protein ◽  
Lipopolysaccharide Binding

IntroductionSmall fiber neuropathy (SFN) is an early manifestation in diabetic polyneuropathy (DPN); however, the mechanisms are not fully understood. In diabetes, SFN is presumed to be common in individuals with overt DPN, enhancing activation of polyol pathway, oxidative stress, advanced glycation end products (AGEs), and inflammation. We explored the relationship between clinicohematological factors related to DPN and pain sensation in the Japanese population.Research design and methodsWe conducted a population-based study, recruiting 1030 individuals (average age 54.4±0.5 years), in 2017, to participate in our Iwaki project. After initial screening by fasting blood glucose and glycohemoglobin A1c (HbA1c) measurements, the subjects were categorized into control (n=894), type 2 diabetes (n=81), and impaired fasting glucose (n=55) groups. Clinical data were gathered, and relationships between pain threshold from intraepidermal electrical stimulation (PINT) and DPN were examined by analysis of variance, post hoc test, and χ2 tests to study correlations among and between groups of the clinical data and DPN.ResultsUnivariate linear regression analyses showed significant correlations between PINT and serum lipopolysaccharide-binding protein (LBP) level (ß=0.1025, p=0.001). Adjustments for the clinical measurements confirmed a positive correlation (ß=0.070, p=0.034). Logistic regression analysis revealed high LBP value (>6.7 mg/dL) as a significant risk factor toward abnormal PINT (≥0.35 mA). LBP significantly correlated with the high-sensitivity C reactive protein, inflammation marker, elevated similarly in both pre-diabetic and overt-diabetic groups, compared with controls, but it did not correlate with a decreased Achilles tendon reflex. In contrast, urine 8-hydroxy-2'-deoxyguanosine, oxidative stress marker, and pentosidine, AGEs, markedly increased in individuals with type 2 diabetes with high HbA1c.ConclusionsIndividuals with high LBP exhibited an elevated PINT in the Japanese population. Low level of inflammation evoked by metabolic endotoxemia is possibly implicated in the pathophysiology of SFN from pre-diabetic stage.

scholarly journals Impact of type 2 diabetes and microvascular complications on mortality and cardiovascular outcomes in a multiethnic Asian population

2021 ◽  
Vol 9 (1) ◽  
pp. e001413
Author(s):  
Jonathan Yap ◽  
Kamalesh Anbalakan ◽  
Wan Ting Tay ◽  
Daniel Ting ◽  
Carol Yim Cheung ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Population Based ◽  
Cardiovascular Outcomes ◽  
Microvascular Complication ◽  
The Impact ◽  
Hba1c Levels

IntroductionDiabetes mellitus is a growing public health epidemic in Asia. We examined the impact of type 2 diabetes, glycemic control and microvascular complications on mortality and cardiovascular outcomes in a multiethnic population-based cohort of Asians without prior cardiovascular disease.Research design and methodsThis was a prospective population-based cohort study in Singapore comprising participants from the three major Asian ethnic groups: Chinese, Malays and Indians, with baseline examination in 2004–2011. Participants with type 1 diabetes and those with cardiovascular disease at baseline were excluded. Type 2 diabetes, Hemoglobin A1c (HbA1c) levels and presence of microvascular complications (diabetic retinopathy and nephropathy) were defined at baseline. The primary outcome was all-cause mortality and major adverse cardiovascular events (MACEs), defined as a composite of cardiovascular mortality, myocardial infarction, stroke and revascularization, collected using a national registry.ResultsA total of 8541 subjects were included, of which 1890 had type 2 diabetes at baseline. Subjects were followed for a median of 6.4 (IQR 4.8–8.8) years. Diabetes was a significant predictor of mortality (adjusted HR 1.74, 95% CI 1.45 to 2.08, p<0.001) and MACE (adjusted HR 1.64, 95% CI 1.39 to 1.93, p<0.001). In those with diabetes, higher HbA1c levels were associated with increased MACE rates (adjusted HR (per 1% increase) 1.18, 95% CI 1.11 to 1.26, p<0.001) but not mortality (p=0.115). Subjects with two microvascular complications had significantly higher mortality and MACE compared with those with only either microvascular complication (adjusted p<0.05) and no microvascular complication (adjusted p<0.05).ConclusionDiabetes is a significant predictor of mortality and cardiovascular morbidity in Asian patients without prior cardiovascular disease. Among patients with type 2 diabetes, poorer glycemic control was associated with increased MACE but not mortality rates. Greater burden of microvascular complications identified a subset of patients with poorer outcomes.

scholarly journals Prevalence of radiographic hip dysplasia in japanese population-based study

2021 ◽  
pp. 1-16
Author(s):  
Veronica K. Cheng ◽  
Masahiro Hasegawa ◽  
Tetsuya Hattori ◽  
Naoya Ito ◽  
Erikka Linn ◽  
...  
Keyword(s):  
Japanese Population ◽  
Hip Dysplasia ◽  
Population Based ◽  
Population Based Study

scholarly journals Zastosowanie elektroterapii TENS w łagodzeniu bólu porodowego / Application of TENS electrotherapy in alleviating labour pain

2016 ◽  
Vol 15 (2) ◽  
pp. 59-62
Author(s):  
Magdalena Sowa ◽  
Katarzyna Ciechanowska ◽  
Iwona Głowacka
Keyword(s):  
Electrical Stimulation ◽  
Pain Threshold ◽  
Labour Pain ◽  
Endogenous Opioids ◽  
Transcutaneous Electrical Stimulation ◽  
Pain Sensation ◽  
Transcutaneous Electric Nerve Stimulation ◽  
Obstetric Practice ◽  
Electric Nerve Stimulation ◽  
The Impact

Abstract Introduction. Easing labour pain is an extremely important issue in obstetric practice. Various physiotherapy methods are increasingly often applied in obstetric practice. Transcutaneous electric nerve stimulation (TENS) aiming at central and peripheral modulation of pain sensation is one of them.Aim. The aim of the study was to analyse the impact of transcutaneous electrical stimulation (TENS) on easing labour pain.Summary. The TENS method is regarded as effective since it increases both the pain threshold and secretion of endogenous opioids. Non-pharmacological methods of pain management during labour, including electrotherapy TENS methods are safe and can be used in most patients.

An Examination by Forearm EMG on Pain Reaction Time to Radiant Heat

1993 ◽  
Vol 76 (3_suppl) ◽  
pp. 1139-1146 ◽  
Author(s):  
Toshiteru Hatayama ◽  
Kayoko Shimizu
Keyword(s):  
Reaction Time ◽  
Time Delay ◽  
Skin Temperature ◽  
Motor Response ◽  
Pain Threshold ◽  
Radiant Heat ◽  
Repeated Measurements ◽  
Pain Sensation ◽  
Pain Thresholds ◽  
Pain Reaction

The present study was done to estimate rise in skin temperature during a pain reaction time (pain RT) as a means of investigating why a pricking pain threshold, produced by thermal stimulation using time method, often increases during repeated measurements. The pain RT, or the time-delay between occurrence of pain sensation and a subsequent motor response, was measured by making EMG recording on a forearm. The radiant heat stimuli were three, 200, 300, and 350 mcal/sec./cm2, each of which was given through a round radiation window of an algesiometer head. Analysis showed that the pain RTs would be too short to explain higher pain thresholds often found using the time method.

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