Controlled release of a heterogeneous human placental matrix from PLGA microparticles to modulate angiogenesis

2016 ◽  
Vol 6 (2) ◽  
pp. 174-183 ◽  
Author(s):  
Sarah Tonello ◽  
Marc C. Moore ◽  
Blanka Sharma ◽  
Jon Dobson ◽  
Peter S. McFetridge
Keyword(s):  
Controlled Release ◽  
Plga Microparticles

Controlled Release of Insulin Granules from PLGA Microparticles for Glucose Modulation in Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2279-PUB ◽  
Author(s):  
ROSITA PRIMAVERA ◽  
MIRKO MAGNONE ◽  
DANIELE DI MASCOLO ◽  
ELENA ZOCCHI ◽  
ANGELO DE PASCALE ◽  
...  
Keyword(s):  
Controlled Release ◽  
Insulin Granules ◽  
Plga Microparticles

Controlled Release of Bone Growth Factors from Injectable, Biodegradable Polymer Scaffolds for Bone Tissue Engineering

2000 ◽  
Vol 662 ◽  
Author(s):  
Elizabeth L. Hedberg ◽  
Antonios G. Mikos
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Release Kinetics ◽  
Salt Content ◽  
Burst Effect ◽  
Plga Microparticles ◽  
Model Drug

AbstractThe objective of this research is to fabricate injectable, polymeric composites that will act as scaffolds for bone ingrowth as well as carriers for the controlled release of bone growth factors. To that end, the injectable polyester poly(propylene fumarate) (PPF) was loaded with poly(DLlactic-co-glycolic acid) (PLGA) microparticles carrying the model drug FITC-dextran. This preparation was then crosslinked with N-vinyl pyrrolidinone in the presence of benzoyl peroxide as initiator and sodium chloride (NaCl) as leachable porogen. The encapsulation of growth factors in microparticles is necessary to minimize their denaturation during scaffold crosslinking. PLGA microparticles (0.04 g microparticles/g PPF) were incorporated into PPF composites having variable NaCl weight percents (50 and 70 wt% NaCl) and the effect on FITC-dextran release kinetics was determined in vitro for cylinders of diameter 6.5 mm and height 13.0 mm. The FITC-dextran loaded microparticles alone exhibited a large initial burst effect, while the composite materials displayed a smaller burst effect and a longer linear region of release. At day 3, 54.6±2.1%, 5.1±0.9%, and 12.5±0.3% of loaded FITC-dextran was released into pH 7.4 phosphate buffered saline from the microparticles, the 50 wt% NaCl, and the 70 wt% NaCl composites, respectively. By day 28, 90.9±6.9%, 12.7±1.7%, and 34.4±0.4% of loaded FITC-dextran was released. Our results demonstrate that PLGA microparticles can be incorporated into PPF composites and that the release kinetics of FITC-dextran can be systematically manipulated through alteration of the composite initial salt content.

Long-term controlled release of PLGA microparticles containing antidepressant mirtazapine

2014 ◽  
Vol 21 (2) ◽  
pp. 214-221 ◽  
Author(s):  
Jakub Vysloužil ◽  
Petr Doležel ◽  
Martina Kejdušová ◽  
Vratislav Košťál ◽  
Ludvík Beneš ◽  
...  
Keyword(s):  
Controlled Release ◽  
Plga Microparticles

Controlled release of bioactive recombinant human growth hormone from PLGA microparticles

2010 ◽  
Vol 27 (6) ◽  
pp. 552-560 ◽  
Author(s):  
Md. Rafi ◽  
Surinder M. Singh ◽  
Vibhu Kanchan ◽  
C. K. Anish ◽  
Amulya K. Panda
Keyword(s):  
Growth Hormone ◽  
Controlled Release ◽  
Human Growth Hormone ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Plga Microparticles

Multimodal Imaging of Drug and Excipients in Rat Lungs following an inhaled administration of controlled-release drug laden PLGA microparticles.

The Analyst ◽  
2021 ◽  
Author(s):  
Eve Robinson ◽  
Paul Giffen ◽  
Dave Hassall ◽  
Doug Ball ◽  
Heather Reid ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Pharmaceutical Industry ◽  
Multimodal Imaging ◽  
Respiratory Illnesses ◽  
Release Drug ◽  
Rat Lungs ◽  
Plga Microparticles ◽  
Controlled Release Formulations

Controlled-release formulations, in the form of micro- or nanoparticles, are increasingly attractive to the pharmaceutical industry for drug delivery. For respiratory illnesses, controlled-release microparticle formulations provide an opportunity to deliver...

scholarly journals Self-healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches

2018 ◽  
Vol 4 (1) ◽  
pp. 116-128 ◽  
Author(s):  
J. Maxwell Mazzara ◽  
Lukasz J. Ochyl ◽  
Justin K. Y. Hong ◽  
James J. Moon ◽  
Mark R. Prausnitz ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Healing ◽  
Vaccine Antigens ◽  
Plga Microparticles

scholarly journals Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 873 ◽  
Author(s):  
Marcilia Costa ◽  
Anderson Feitosa ◽  
Fátima Oliveira ◽  
Bruno Cavalcanti ◽  
Eufrânio da Silva ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Controlled Release ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Plga Microparticles
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