QbD-based development of α-linolenic acid potentiated nanoemulsion for targeted delivery of doxorubicin in DMBA-induced mammary gland carcinoma: in vitro and in vivo evaluation

2018 ◽  
Vol 8 (5) ◽  
pp. 1313-1334 ◽  
Author(s):  
Chandra Bhushan Tripathi ◽  
Poonam Parashar ◽  
Malti Arya ◽  
Mahendra Singh ◽  
Jovita Kanoujia ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Linolenic Acid ◽  
Targeted Delivery ◽  
In Vivo Evaluation ◽  
Mammary Gland Carcinoma ◽  
Gland Carcinoma

scholarly journals Establishment and Characterization of Canine Mammary Gland Carcinoma Cell Lines with Vasculogenic Mimicry Ability in vitro and in vivo

2019 ◽  
Author(s):  
Patricia de Faria Lainetti ◽  
Andressa Brandi ◽  
Antonio Fernando Leis Filho ◽  
Maria Carolina Mangini Prado ◽  
Priscila Emiko Kobayashi ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Cell Lines ◽  
Vasculogenic Mimicry ◽  
Preclinical Model ◽  
Mammary Gland Carcinoma ◽  
Gland Carcinoma ◽  
Canine Mammary Gland

Mammary neoplasms affect a population of uncastrated and elderly female dogs and most of these neoplasms are malignant. In order to study this disease cell culture presents itself as a promising preclinical model, creating the opportunity to deposit cell lines at a cell bank, allowing a great repetition of the assays and making the validation of the results more reliable. Including, in vitro experiments for vasculogenic mimicry (VM) evaluation. VM is related to cancer cells capable of generate vascular-like structures without endothelial cells, mimicking the vasculogenic process. The aim of this study was to establish and characterize ten cell lines from canine mammary gland tumour according to immunophenotype and tumorigenicity, and with its ability to form vasculogenic mimicry-like structures in vitro. Fifteen samples from canine mammary gland carcinoma were collected and cultured in vitro and ten cell lines were established and characterized. Cells were evaluated for morphology, phenotype, vascular mimicry and tumorigenicity. All cell lines presented spindle shape morphology and expressed concomitant pan-cytokeratin and CK8/18. Four cell lines had vasculogenic mimicry ability and two cell showed in vivo tumorigenic potential. Cell characterization of those lines will help to create a database for more knowledge of mammary gland carcinomas in dogs, including studies of tumor behavior and new therapeutic targets.

Novel folate-targeted docetaxel-loaded nanoparticles for tumour targeting: in vitro and in vivo evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64306-64314 ◽  
Author(s):  
M. H. Han ◽  
Z. T. Li ◽  
D. D. Bi ◽  
Y. F. Guo ◽  
H. X. Kuang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Tumour Targeting ◽  
Breast Cancer Therapy ◽  
In Vivo Evaluation ◽  
Targeted Delivery System

Cholesterol-PEG1000-FA (folic acid) was synthesized as a stabilizer to encapsulate DTX, for the construction of a promising targeted delivery system for breast cancer therapy.

scholarly journals The anticancer efficacy of paclitaxel liposomes modified with low-toxicity hydrophobic cell-penetrating peptides in breast cancer: an in vitro and in vivo evaluation

RSC Advances ◽  
2018 ◽  
Vol 8 (43) ◽  
pp. 24084-24093 ◽  
Author(s):  
Qi Zhang ◽  
Jing Wang ◽  
Hao Zhang ◽  
Dan Liu ◽  
Linlin Ming ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
In Vivo Evaluation ◽  
Anticancer Efficacy ◽  
Cell Penetrating ◽  
Low Toxicity

Hydrophobic cell penetrating peptide PFVYLI-modified liposomes have been developed for the targeted delivery of PTX into tumors.

Tumor Targeted Delivery of an Anti‐Cancer Therapeutic: An In Vitro and In Vivo Evaluation

2020 ◽  
pp. 2001261
Author(s):  
You Jung Kang ◽  
Claire K. Holley ◽  
Mohammad Reza Abidian ◽  
Achuthamangalam B. Madhankumar ◽  
James Connor ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
In Vivo Evaluation ◽  
Anti Cancer

Development of an α-linolenic acid containing soft nanocarrier for oral delivery: in vitro and in vivo evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77590-77602 ◽  
Author(s):  
Mahendra Singh ◽  
Jovita Kanoujia ◽  
Pooja Singh ◽  
Chandra B. Tripathi ◽  
Malti Arya ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Linolenic Acid ◽  
Oral Delivery ◽  
Lipid Levels ◽  
In Vivo Evaluation

Use of α-linolenic acid as an oil phase for microemulsion preparation with synergistic effect of oil in lowering of lipid levels in combination with simvastatin.

scholarly journals Correction: In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups

RSC Advances ◽  
2017 ◽  
Vol 7 (48) ◽  
pp. 30049-30050
Author(s):  
Zhihong Zhu ◽  
Dongyang Li ◽  
Yuenan Li ◽  
Xinggang Yang ◽  
Weisan Pan
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Amphiphilic Copolymers ◽  
In Vivo Evaluation

Correction for ‘In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups’ by Zhihong Zhu et al., RSC Adv., 2017, 7, 23942–23953.

BRAIN-TARGETED DELIVERY OF ANDROGRAPHOLIDE USING SOLID LIPID NANOPARTICLES: IN VITRO AND IN VIVO EVALUATION

2017 ◽  
Author(s):  
G Graverini ◽  
V Piazzini ◽  
E Landucci ◽  
D Pantano ◽  
P Nardiello ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Evaluation ◽  
Solid Lipid
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