Preparation and characterization of 3D printed PLA microneedle arrays for prolonged transdermal drug delivery of estradiol valerate

2021 ◽  
Author(s):  
Afsoun Khosraviboroujeni ◽  
Seyedeh Zahra Mirdamadian ◽  
Mohsen Minaiyan ◽  
Azade Taheri
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Estradiol Valerate ◽  
3D Printed ◽  
Microneedle Arrays

scholarly journals Characterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77289 ◽  
Author(s):  
Yusuf K. Demir ◽  
Zafer Akan ◽  
Oya Kerimoglu
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Microneedle Arrays

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

scholarly journals A Novel 3D Printed Hollow Microneedle Microelectromechanical System for Controlled, Personalised Transdermal Drug Delivery

2020 ◽  
pp. 101815
Author(s):  
Sophia N. Economidou ◽  
Md. Jasim Uddin ◽  
Manuel J. Marques ◽  
Dennis Douroumis ◽  
Wan Ting Sow ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Microelectromechanical System ◽  
Hollow Microneedle ◽  
3D Printed

Microneedle arrays as medical devices for enhanced transdermal drug delivery

2011 ◽  
Vol 8 (4) ◽  
pp. 459-482 ◽  
Author(s):  
Martin J Garland ◽  
Katarzyna Migalska ◽  
Tuan Mazlelaa Tuan Mahmood ◽  
Thakur Raghu Raj Singh ◽  
A David Woolfson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Medical Devices ◽  
Transdermal Drug Delivery ◽  
Microneedle Arrays

Preparation and characterization of aceclofenac-loaded amphiphilogels for transdermal drug delivery

2021 ◽  
Vol 14 (3) ◽  
pp. 1298-1304
Author(s):  
Himani Bajaj ◽  
Vinod Singh ◽  
Ranjit Singh ◽  
Tirath Kumar
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery

Biodegradable 3D printed polymer microneedles for transdermal drug delivery

Lab on a Chip ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 1223-1230 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
3D Printer ◽  
3D Printed

DIY drug delivery: an easy way to get sharp break-away drug-loaded microneedles using an inexpensive off-the-shelf 3D printer.

Novel structure of microneedle arrays for the transdermal drug delivery applications

2018 ◽  
Vol 14 (1) ◽  
pp. 163-164 ◽  
Author(s):  
Hirofumi Miki ◽  
Ryota Nishikata ◽  
Koji Minehira ◽  
Shigeki Tsuchitani
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Novel Structure ◽  
Microneedle Arrays ◽  
Drug Delivery Applications

Design, Fabrication and Characterization of in-Plane Titanium Microneedles for Transdermal Drug Delivery

2011 ◽  
Vol 483 ◽  
pp. 532-536 ◽  
Author(s):  
Wen Li ◽  
Yi Ming Zhang ◽  
Jing Chen
Keyword(s):  
Drug Delivery ◽  
Gastrointestinal Tract ◽  
Penetration Depth ◽  
Transdermal Drug Delivery ◽  
Oral Route ◽  
Hypodermic Injection ◽  
Novel Device ◽  
Fabrication And Characterization

Transdermal drug delivery is an alternative way to transport drugs compared with oral route and hypodermic injection. The problem of oral route is the degradation of drugs in the gastrointestinal tract and their elimination through the liver. The hypodermic injection is problematic due to the pain and inconvenient for patients [1]. As a novel device of transdermal drug delivery, microneedles offer several advantages including the painless injection, the precise penetration depth under the skin and the long-term, continuous deliveries

Preparation of hollow out-of-plane hafnium oxide microneedle arrays for transdermal drug delivery

2017 ◽  
Vol 23 (12) ◽  
pp. 5887-5892 ◽  
Author(s):  
Yong-hua Zhang ◽  
Stephen A. Campbell ◽  
Sreejith Karthikeyan
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Hafnium Oxide ◽  
Out Of Plane ◽  
Microneedle Arrays
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