scholarly journals Improving the Sensitivity of Mass Spectrometry by Using a New Sheath Flow Electrospray Emitter Array at Subambient Pressures

2014 ◽  
Vol 25 (12) ◽  
pp. 2028-2037 ◽  
Author(s):  
Jonathan T. Cox ◽  
Ioan Marginean ◽  
Ryan T. Kelly ◽  
Richard D. Smith ◽  
Keqi Tang
Keyword(s):  
Mass Spectrometry ◽  
Sheath Flow ◽  
Emitter Array ◽  
Electrospray Emitter

Robotic sheath-flow probe electrospray ionization/mass spectrometry (sfPESI/MS): development of a touch sensor for samples in a multiwell plastic plate

2020 ◽  
Vol 12 (22) ◽  
pp. 2812-2819
Author(s):  
Kenzo Hiraoka ◽  
Osamu Ariyada ◽  
Ryo Sekine ◽  
Satoshi Ninomiya ◽  
Dilshadbek T. Usmanov ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Plastic Plate ◽  
Flow Probe ◽  
Sheath Flow ◽  
Touch Sensor ◽  
Probe Electrospray Ionization

In the previous work, sheath-flow probe electrospray ionization (sfPESI) equipped with a touch sensor was developed for conducting samples.

scholarly journals Investigation of electrospray for a capillary electrophoresis–mass spectrometry interface in reverse polarity and negative ion mode

2019 ◽  
Vol 25 (1) ◽  
pp. 157-163 ◽  
Author(s):  
Morgan Stickney ◽  
Qiangwei Xia ◽  
I Jonathan Amster
Keyword(s):  
Mass Spectrometry ◽  
Electroosmotic Flow ◽  
Negative Ion ◽  
Reverse Polarity ◽  
Sheath Flow ◽  
Analytical Technique ◽  
Sheath Liquid ◽  
Electrospray Process ◽  
Negative Ionization ◽  
Negative Ion Mode

Capillary zone electrophoresis (CZE) paired with mass spectrometry (MS) is a powerful analytical technique for examining mixtures of ionic analytes such as glycosaminoglycans. This study examines the mechanics of the electrospray process for a sheath flow CZE-MS interface under reverse polarity negative ionization conditions. Liquid flow in a sheath flow nano-electrospray CZE-MS interface is driven by two mechanisms, electroosmotic flow and electrospray nebulization. The contribution of these two processes to the overall flow of solution to the electrospray tip is influenced by the surface coatings of the sheath flow emitter tip and by the solvent composition. We have investigated the application of this interface to the reverse polarity separation of glycosaminoglycans and find that the role of electroosmotic flow is far less than has been reported previously, and the electrospray process itself is the largest contributor to the flow of the sheath liquid.

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