scholarly journals The Alzheimer’s disease-8 and Montreal Cognitive Assessment as screening tools for neurocognitive impairment in HIV-infected persons

2013 ◽  
Vol 19 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Edgar Turner Overton ◽  
Tej D. Azad ◽  
Neva Parker ◽  
Debra Demarco Shaw ◽  
Judy Frain ◽  
...  
2019 ◽  
Author(s):  
Yan-rong Zhang ◽  
Yun-Long Ding ◽  
Ke-liang Chen ◽  
Yan Liu ◽  
Can Wei ◽  
...  

Abstract Background To determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI), mild Alzheimer’s disease (AD), and moderate-severe (AD), as well as their sensitivity and specificity.Methods MCI (n=456), mild AD (n=502) and moderate-severe AD (n=102) patients were recruited from the memory clinic, Huashan Hospital, Shanghai, China. NC (n=329) were recruited from health checkup outpatients. Five MoCA-BC item scores were collected in interviews.Results The MoCA-BC orientation test had high sensitivity and specificity for discrimination among MCI, mild AD and moderate-severe AD. The delayed recall memory test had high sensitivity and specificity for MCI screening. The verbal fluency test was efficient for detecting MCI and differentiating AD severity.Conclusions Various items of the MoCA-BC can identify MCI patients early and identify the severity of dementia.


2019 ◽  
Author(s):  
Yan-rong Zhang ◽  
Yun-Long Ding ◽  
Ke-liang Chen ◽  
Yan Liu ◽  
Can Wei ◽  
...  

Abstract Background To determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI), mild Alzheimer’s disease (AD), and moderate-severe (AD). Methods MCI (n=456), mild AD (n=502) and moderate-severe AD (n=102) patients were recruited from the memory clinic, Huashan Hospital, Shanghai, China. NC (n=329) were recruited from health checkup outpatients. Five MoCA-BC item scores were collected in interviews. Results The MoCA-BC orientation test had high sensitivity and specificity for discrimination among MCI, mild AD and moderate-severe AD. The delay recall memory test had high sensitivity and specificity for MCI screening. The verbal fluency test was efficient for detecting MCI and differentiating AD severity. Conclusions Various items of the MoCA-BC can identify MCI patients early and identify the severity of dementia.


2018 ◽  
Vol 31 (04) ◽  
pp. 491-504 ◽  
Author(s):  
Tiago C. C. Pinto ◽  
Leonardo Machado ◽  
Tatiana M. Bulgacov ◽  
Antônio L. Rodrigues-Júnior ◽  
Maria L. G. Costa ◽  
...  

ABSTRACTObjective:To compare the accuracy of Mini-Mental State Examination (MMSE) and of the Montreal Cognitive Assessment (MoCA) in tracking mild cognitive impairment (MCI) and Alzheimer’s Disease (AD).Method:A Systematic review of the PubMed, Bireme, Science Direct, Cochrane Library, and PsycInfo databases was conducted. Using inclusion and exclusion criteria and staring with 1,629 articles, 34 articles were selected. The quality of the selected research was evaluated through the Quality Assessment of Diagnostic Accuracy Studies 2 tool (QUADAS-2).Result:More than 80% of the articles showed MoCA to be superior to MMSE in discriminating between individuals with mild cognitive impairment and no cognitive impairment. The area under the curve varied from 0.71 to 0.99 for MoCA, and 0.43 to 0.94 for MMSE, when evaluating the ability to discriminate MCI in the cognitively healthy elderly individuals, and 0.87 to 0.99 and 0.67 to 0.99, respectively, when evaluating the detection of AD. The AUC mean value for MoCA was significantly larger compared to the MMSE in discriminating MCI from control [0.883 (CI 95% 0.855-0.912) vs MMSE 0.780 (CI 95% 0.740-0.820) p < 0.001].Conclusion:The screening tool MoCA is superior to MMSE in the identification of MCI, and both tests were found to be accurate in the detection of AD.


2021 ◽  
pp. 1-11
Author(s):  
Xiaolei Liu ◽  
Xinjie Chen ◽  
Xianbo Zhou ◽  
Yajun Shang ◽  
Fan Xu ◽  
...  

Background: A valid, reliable, accessible, engaging, and affordable digital cognitive screen instrument for clinical use is in urgent demand. Objective: To assess the clinical utility of the MemTrax memory test for early detection of cognitive impairment in a Chinese cohort. Methods: The 2.5-minute MemTrax and the Montreal Cognitive Assessment (MoCA) were performed by 50 clinically diagnosed cognitively normal (CON), 50 mild cognitive impairment due to AD (MCI-AD), and 50 Alzheimer’s disease (AD) volunteer participants. The percentage of correct responses (MTx-% C), the mean response time (MTx-RT), and the composite scores (MTx-Cp) of MemTrax and the MoCA scores were comparatively analyzed and receiver operating characteristic (ROC) curves generated. Results: Multivariate linear regression analyses indicated MTx-% C, MTx-Cp, and the MoCA score were significantly lower in MCI-AD versus CON and in AD versus MCI-AD groups (all with p≤0.001). For the differentiation of MCI-AD from CON, an optimized MTx-% C cutoff of 81% had 72% sensitivity and 84% specificity with an area under the curve (AUC) of 0.839, whereas the MoCA score of 23 had 54% sensitivity and 86% specificity with an AUC of 0.740. For the differentiation of AD from MCI-AD, MTx-Cp of 43.0 had 70% sensitivity and 82% specificity with an AUC of 0.799, whereas the MoCA score of 20 had 84% sensitivity and 62% specificity with an AUC of 0.767. Conclusion: MemTrax can effectively detect both clinically diagnosed MCI and AD with better accuracy as compared to the MoCA based on AUCs in a Chinese cohort.


2014 ◽  
Vol 03 (04) ◽  
pp. 160-167 ◽  
Author(s):  
Jacqueline C. Dominguez ◽  
Jennifer Rose Soriano ◽  
Cely D. Magpantay ◽  
Mary Grace S. Orquiza ◽  
Wynette Marie Solis ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document