scholarly journals Cigarette smoke and nicotine effects on brain proinflammatory responses and behavioral and motor function in HIV-1 transgenic rats

2018 ◽  
Vol 24 (2) ◽  
pp. 246-253 ◽  
Author(s):  
Walter Royal ◽  
Adem Can ◽  
Todd D. Gould ◽  
Ming Guo ◽  
Jared Huse ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Motor Function ◽  
Transgenic Rats ◽  
Proinflammatory Responses ◽  
Hiv 1

scholarly journals Endotoxin-Mediated Downregulation of Hepatic Drug Transporters in HIV-1 Transgenic Rats

2016 ◽  
Vol 44 (5) ◽  
pp. 709-719 ◽  
Author(s):  
R. H. Ghoneim ◽  
M. Piquette-Miller
Keyword(s):  
Drug Transporters ◽  
Transgenic Rats ◽  
Hepatic Drug ◽  
Hiv 1

scholarly journals Imaging Upregulated Brain Arachidonic Acid Metabolism in HIV-1 Transgenic Rats

2015 ◽  
Vol 35 (8) ◽  
pp. 1386-1386
Author(s):  
Mireille Basselin ◽  
Epolia Ramadan ◽  
Miki Igarashi ◽  
Lisa Chang ◽  
Mei Chen ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Arachidonic Acid Metabolism ◽  
Transgenic Rats ◽  
Hiv 1

Cigarette smoke and nicotine effects on behavior in HIV transgenic rats

2022 ◽  
Vol 417 ◽  
pp. 113591
Author(s):  
Walter Royal ◽  
Joseph Bryant ◽  
Harry Davis ◽  
Ming Guo
Keyword(s):  
Cigarette Smoke ◽  
Transgenic Rats

128. Selective presence of proinflammatory mediators in the hippocampus of HIV-1 transgenic rats

2009 ◽  
Vol 23 ◽  
pp. S60
Author(s):  
A.F. Wagner ◽  
L.J. Jannach ◽  
R.L. Bigler ◽  
D.T. Lysle
Keyword(s):  
Transgenic Rats ◽  
Proinflammatory Mediators ◽  
Hiv 1

scholarly journals MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats

2019 ◽  
Vol 317 (2) ◽  
pp. C390-C397 ◽  
Author(s):  
Abiodun T. Kukoyi ◽  
Xian Fan ◽  
Bashar S. Staitieh ◽  
Brooks M. Hybertson ◽  
Bifeng Gao ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Barrier Function ◽  
Transgene Expression ◽  
Antioxidant Defenses ◽  
Transgenic Rats ◽  
Alveolar Epithelial ◽  
Barrier Formation ◽  
Hiv 1 ◽  
Expression And Activity

Chronic HIV infection causes redox stress and increases the risk of acute and chronic lung injury, even when individuals are adherent to antiretroviral therapy. HIV-1 transgene expression in rats inhibits nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which regulates antioxidant defenses and alveolar epithelial cell (AEC) barrier function, but the mechanism is unknown. In this study, we present novel evidence that these pathological effects of HIV are mediated by microRNA-144 (miR-144). HIV-1 transgene expression in vivo increases the expression of miR-144 in the alveolar epithelium, and this can be replicated by direct exposure of naïve primary AECs to either Tat or gp120 ex vivo. Further, treating naïve primary AECs with a miR-144 mimic decreased the expression and activity of Nrf2 and inhibited their barrier formation. In contrast, treatment with a miR-144 antagomir increased the expression and activity of Nrf2 and improved barrier function in primary AECs isolated from HIV-1 transgenic rats. Importantly, either delivering the miR-144 antagomir intratracheally, or directly activating Nrf2 by dietary treatment with PB123, increased Nrf2 expression and barrier formation in HIV-1 transgenic rat AECs. This study provides new experimental evidence that HIV-induced inhibition of Nrf2 and consequent AEC barrier dysfunction are mediated via miR-144, and that these pathophysiological effects can be mitigated in vivo by either directly antagonizing miR-144 or activating Nrf2. Our findings suggest that targeting the inhibition of Nrf2 in individuals living with HIV could enhance their lung health and decrease the lung-specific morbidity and mortality that persists despite antiretroviral therapy.

scholarly journals HIV-1 transgenic rats develop T cell abnormalities

Virology ◽  
2004 ◽  
Vol 321 (1) ◽  
pp. 111-119 ◽  
Author(s):  
William Reid ◽  
Sayed Abdelwahab ◽  
Mariola Sadowska ◽  
David Huso ◽  
Ashley Neal ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Rats ◽  
Hiv 1
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