Synthesis of functionalized chromones through sequential reactions in aqueous media

2014 ◽  
Vol 12 (30) ◽  
pp. 5757-5765 ◽  
Author(s):  
Saber Mehrparvar ◽  
Saeed Balalaie ◽  
Mahnaz Rabbanizadeh ◽  
Frank Rominger ◽  
Elmira Ghabraie
Keyword(s):  
Aqueous Media ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Primary Alcohols ◽  
Meldrum’S Acid ◽  
Synthesis Protocol ◽  
Sequential Reactions

An efficient synthesis protocol has been developed for diversity-oriented functionalized compounds via four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols in aqueous media.

One-Pot Three-Component Reaction between 2-Aminopyridines, Aldehydes and Meldrum’s Acid in Water: An Efficient Synthesis of β-Amino Acids

Synlett ◽  
2008 ◽  
Vol 2008 (20) ◽  
pp. 3177-3179 ◽  
Author(s):  
Mehdi Adib ◽  
Solmaz Fatemi ◽  
Meisam Nosrati ◽  
Hamid Bijanzadeh
Keyword(s):  
Amino Acids ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
Three Component Reaction

Synthesis of Disubstituted γ-Butyrolactones and Spirocyclopropanes via Multicomponent Reaction of Aldehydes, Meldrum’s Acid and Sulfoxonium Ylides

2021 ◽  
Author(s):  
Shan-Shan Li ◽  
Qi Qin ◽  
Zhuang Qi ◽  
Li-Miao Yang ◽  
Yun Kang ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Mild Conditions

An efficient synthesis of disubstituted γ-butyrolactones and spirocyclopropanes via multicomponent reaction of aldehydes, Meldrum’s acid and sulfoxonium ylides has been developed. Under mild conditions, electron-rich aromatic aldehydes reacted with Meldrum’s...

scholarly journals One Pot, Four Component Synthesis of Phthalazine-1,4-diones Derivatives in [BMIM][OH] Medium

2019 ◽  
Vol 32 (1) ◽  
pp. 45-48
Author(s):  
D.P. Loka Maheshwari ◽  
B. Satyanarayana
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Diethyl Phthalate ◽  
High Yield ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot

[BMIM][OH] mediated, green and efficient synthesis of phthalazines (5) have been developed by condensing diethyl phthalate (1), ethyl cyanohydrazide (2), substituted benzaldehyde (3) and malononitrile (4) in the presence of Meldrum’s acid at 60-65 °C and at room temperature for 60-90 min. The importance of this method includes shorter reaction time and high yield.

Efficient synthesis of acetylated bicyclic [n.3.0] hydroxypyrroles from cyclic lactams via flash vacuum pyrolysis of Meldrum's acid derivatives

1988 ◽  
Vol 53 (24) ◽  
pp. 5680-5685 ◽  
Author(s):  
Jean Claude Pommelet ◽  
Hamid Dhimane ◽  
Josselin Chuche ◽  
Jean Pierre Celerier ◽  
Mansour Haddad ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Flash Vacuum Pyrolysis ◽  
Vacuum Pyrolysis ◽  
Meldrum's Acid Derivatives

Bentonite Catalyzed an Efficient and Green Synthesis of Arylidene Meldrum's Acid Derivatives in Aqueous Media

2020 ◽  
Vol 17 ◽  
Author(s):  
Mahdieh Yahyazadehfar ◽  
Sayed Ali Ahmadi ◽  
Enayatollah Sheikhhosseini ◽  
Dadkhoda Ghazanfari
Keyword(s):  
Condensation Reaction ◽  
Aqueous Media ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Reusable Catalyst ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Environmental Aspect ◽  
Knoevenagel Condensation Reaction ◽  
Work Up

: In the present paper, a simple, highly efficient, and environmentally friendly protocol was proposed for the Knoevenagel condensation reaction of aromatic aldehydes using Meldrum’s acid (2,2-dimethyl-4,6-dioxo-1,3-dioxane) with bentonite as an available non-toxic mineral catalyst exposed to aqueous media under green conditions. Together with the substitution protocol of electron-donating or -withdrawing groups, all reactions were finalized from 5 to 120 min in water at 90°C. With regard to such reactions, purification of columns on products was not a requirement. Considering the environmental aspect, use of water as a green solvent, utilization of a reusable catalyst, simple work-up process and steps, as well as rapid reaction times were taken into account as some characteristics of these chemical reactions.

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