An efficient synthesis protocol has been developed for diversity-oriented functionalized compounds via four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols in aqueous media.
An efficient synthesis of disubstituted γ-butyrolactones and spirocyclopropanes via multicomponent reaction of aldehydes, Meldrum’s acid and sulfoxonium ylides has been developed. Under mild conditions, electron-rich aromatic aldehydes reacted with Meldrum’s...
[BMIM][OH] mediated, green and efficient synthesis of phthalazines (5) have been developed by condensing diethyl phthalate (1), ethyl cyanohydrazide (2), substituted benzaldehyde (3) and malononitrile (4) in the presence of Meldrum’s acid at 60-65 °C and at room temperature for 60-90 min. The importance of this method includes shorter reaction time and high yield.
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An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline-
2,5,10(1H)-triones was developed for the first time. The process proceeded via the
three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid
and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)-
one-ring naphthoquinones have been synthesized with good to high yields in refluxing
ethanol as a green reaction medium. This protocol is simple and effective as well as does
not involve the assistance of the catalyst, additive, or hazardous solvents.
Rh2(Opiv)4-Catalyzed Reactions of Diazo Compound Derived from Meldrum's Acid and Styrenes. Efficient Synthesis of Cyclopropanes