Protective effect of liensinine on periodontitis through its antioxidant effect in mice

2015 ◽  
Vol 58 (6) ◽  
pp. 927-936 ◽  
Author(s):  
Liang Pang ◽  
Kai Zhu ◽  
Xia Feng ◽  
Weiwei Liu ◽  
Deguang Peng ◽  
...  
Keyword(s):  
Protective Effect ◽  
Antioxidant Effect

Antioxidant effect of salidroside and its protective effect against furan-induced hepatocyte damage in mice

2013 ◽  
Vol 4 (5) ◽  
pp. 763 ◽  
Author(s):  
Yuan Yuan ◽  
Si-Jia Wu ◽  
Xin Liu ◽  
Lu-Lu Zhang
Keyword(s):  
Protective Effect ◽  
Antioxidant Effect ◽  
Hepatocyte Damage

ANTIOXIDANT EFFECT AND DNA PROTECTIVE EFFECT OF VARIOUS ENZYMATIC EXTRACTS FROM PERILLA FRUTESCENS VAR. CRISPA

2007 ◽  
Vol 14 (4) ◽  
pp. 335-349 ◽  
Author(s):  
EUN-KYUNG KIM ◽  
SEUNG-JAE LEE ◽  
YOU-JIN JEON ◽  
CHANG-BUM AHN ◽  
MIN DONG SONG ◽  
...  
Keyword(s):  
Protective Effect ◽  
Antioxidant Effect ◽  
Perilla Frutescens

Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota

2021 ◽  
Author(s):  
Akinori Wada ◽  
Masaaki Higashiyama ◽  
Chie Kurihara ◽  
Suguru Ito ◽  
Rina Tanemoto ◽  
...  
Keyword(s):  
Uric Acid ◽  
Gut Microbiota ◽  
Protective Effect ◽  
Antioxidant Effect

scholarly journals Medicinal Properties of Flavonoids: الفلافونويدات وخواصها الدوائية

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Hasan M. H. Muhaisen, Esraa M. M. Ali
Keyword(s):  
Protective Effect ◽  
Folk Medicine ◽  
Epidemiological Studies ◽  
Biological Properties ◽  
Antioxidant Effect ◽  
Present Review ◽  
Isolation And Identification ◽  
Active Constituents ◽  
Antitumour Agents ◽  
Positive Effects

  Flavonoids are ubiquitous in photosynthesizing cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, and honey. Therefore, a significant quantity is consumed in our daily diet. These flavonoids are variously associated with the sensory and nutritional quality of our plant foods. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases. There has been increasing interest in the research on flavonoids from plant sources because of their versatile health benefits reported in various epidemiological studies. Since flavonoids are directly associated with human dietary ingredients and health, there is need to evaluate structure and function relationship. There have been many bioassay guided searches for cytotoxic antitumour agents in plants especially those known to be used in folk medicine for this purpose. This has led to the isolation and identification of quite a large number of active constituents from all the different flavonoid classes, e.g. catechins, flavans, dihydrochalcones, chalcones, flavanones, dihydro-flavonols, flavones, biflavonoids and flavonol. The purpose of the present review is to discuss recent developments in the biochemistry and medicinal aspects of the flavonoids. Flavonoids have received a lot of interest in scientific research over the past 20 years and have had many beneficial and potential effects. Flavonoids have many great advantages as natural compounds compared to therapeutic agents because many diets are rich in polyphenols and are consumed daily and are easily absorbed in the intestines after ingestion, especially flavonoids, have positive effects on health: antioxidants, lethargy, allergies and bacteria, And cancer. The protective effect of flavonoids is primarily due to its antioxidant effect and inhibition of enzymes. The protective effect of flavonoids from diseases is mainly due to their antioxidant effect. Recent research on the biological properties of flavonoids will therefore be a further subject of the present review.

Protective Effect of Melatonin on Infrarenal Aortic Occlusion: This Effect Is Related to Anti-inflammatory Effect and Antioxidant Effect

Inflammation ◽  
2014 ◽  
Vol 37 (4) ◽  
pp. 1111-1119 ◽  
Author(s):  
Ahmet Ahsen ◽  
Yucel Gonul ◽  
Abdurrahman Genc ◽  
Memnune Sena Ulu ◽  
Murat Yagmurca ◽  
...  
Keyword(s):  
Protective Effect ◽  
Antioxidant Effect ◽  
Aortic Occlusion ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect

2008 ◽  
Vol 16 (3) ◽  
pp. 1133-1141 ◽  
Author(s):  
Kyoung Ah Kang ◽  
Rui Zhang ◽  
Mei Jing Piao ◽  
Dong Ok Ko ◽  
Zhi Hong Wang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Cell Damage ◽  
Antioxidant Effect

Protective effect of the extracts from Cnidium officinale against oxidative damage induced by hydrogen peroxide via antioxidant effect

2009 ◽  
Vol 47 (3) ◽  
pp. 525-529 ◽  
Author(s):  
Jin Boo Jeong ◽  
Jae Ho Park ◽  
Hee Kyeong Lee ◽  
So Yeong Ju ◽  
Se Chul Hong ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Antioxidant Effect ◽  
Cnidium Officinale

scholarly journals Protective effect of ademetionine, cytoflavinum and dihydroquercetin in the liver of rats exposed to toxic effects of valproate sodium

2021 ◽  
pp. 56-63
Author(s):  
Л.В. Охремчук ◽  
И.Ж. Семинский
Keyword(s):  
Protective Effect ◽  
Glutathione Reductase ◽  
Sodium Valproate ◽  
Glutathione Transferase ◽  
Malonic Dialdehyde ◽  
Antioxidant Effect ◽  
Toxic Effects ◽  
Glutathione System ◽  
Diene Conjugates ◽  
Valproate Sodium

Введение. Вальпроат натрия влияет на метаболизм гамма-аминомасляной кислоты, предотвращая развитие эпилептических приступов. Многие метаболиты вальпроата натрия потенцируют его клинический эффект, однако, именно они могут приводить к развитию хронической интоксикации с поражением печени. Цель - оценка протекторного эффекта адеметионина (гептрала), цитофлавина и дигидрокверцетина у крыс, подвергнутых токсическому влиянию вальпроата натрия (депакина). Методика. Животным контрольной группы вводили вальпроат натрия в токсической дозе 600 мг/кг интрагастрально 1 раз в день в течение 28 сут. Крысам опытных групп вводили вальпроат натрия в той же дозе с одновременным введением адеметионина, цитофлавина или дигидрокверцетина. Животные выводились из эксперимента на 7-, 14-, 21- и 28-е сут. В гомогенате печени определяли стандартными спектрофотометрическими методами концентрацию диеновых конъюгатов, малонового диальдегида, восстановленного глутатиона и активность ферментов метаболизма глутатиона: глутатионредуктазы, глутатионпероксидазы и глутатионтрансферазы. Результаты. При токсическом воздействии вальпроата натрия в ткани печени развивались процессы гиперпероксидации липидов, которые подтверждались значительным повышением уровня диеновых конъюгатов и малонового диальдегида. Концентрация глутатиона снижалась начиная с 14-х сут эксперимента. Активность глутатионредуктазы повышалась к 14-м сут, а затем к 28-м сут практически достигала значений интактных животных. Активность глутатионтрансферазы начинала снижаться с 14-х сут и сохранялась низкой до конца исследования. Активность глутатионпероксидазы повышалась с 14-х сут эксперимента, достигая максимума к 28-м сут. Протекторный эффект адеметионина при токсическом воздействии вальпроата натрия выражался в снижении содержания диеновых конъюгатов и малонового диальдегида. Одновременно происходила активация системы глутатиона: повышалась активность глутатионтрансферазы и глутатионредуктазы. Антиокислительное действие цитофлавина проявлялось в основном на 1-й нед эксперимента: концентрация диеновых конъюгатов и малонового диальдегида снижалась, активность глутатионредуктазы и глутатионтрансферазы повышалась. Дигидрокверцетин также оказывал антиокислительное действие: концентрация диеновых конъюгатов и малонового диальдегида снижалась. Активность глутатионредуктазы и глутатионтрансферазы увеличивалась по сравнению с контрольными животными. Заключение. Вальпроат натрия в токсической дозе приводит к статистически значимому повышению уровня продуктов перекисного окисления липидов и снижению антиокислительной защиты системы глутатиона в печени крыс. Адеметионин, цитофлавин и дигидрокверцетин способствуют восстановлению баланса системы перекисного окисления липидов и антиоксидантной защиты в печени крыс при токсическом влиянии вальпроата натрия. Наиболее перспективным препаратом защиты является адеметионин, так как он наиболее существенно снижает концентрацию диеновых конъюгатов, малонового диальдегид и повышает активность системы глутатиона на протяжении 28 сут эксперимента. Background. Sodium valproate affects metabolism of gamma-aminobutyric acid to prevent the development of epileptic seizures. Many valproic acid metabolites potentiate its clinical effect; however, specifically these metabolites may result in chronic intoxication with liver damage. Aim: To evaluate the protective effect of ademetionine (Heptral), cytoflavin, and dihydroquircetin in rats exposed to the toxic action of sodium valproate (Depakene). Methods. Animals of the control group were administered valproate sodium at a toxic dose of 600 mg/kg, intragastrically. Rats of the experimental group were administered valproate sodium at a dose of 600 mg/kg with simultaneous administration of ademetionine, cytoflavin and dihydroquercetin. The duration of drug administration in all groups was 7 days, 14 days, 21 days, or 28 days. The contents of diene conjugates, malonic dialdehyde, reduced glutathione, and the activity of glutathione reductase, glutathione peroxidase, and glutathione transferase were measured in liver homogenates with standard spectrophotometric methods. Results. Under the toxic effects of valproate sodium in liver tissue, a significant increase in the contents of diene conjugates and malonic dialdehyde was found. The glutathione concentration decreased starting from day 14 of the experiment. The glutathione reductase activity increased by day 14 and practically reached the values of intact animals by day 28. The glutathione transferase activity began decreasing on day 14 and remained low until the end of study. The glutathione peroxidase activity increased starting from day 14 and reached maximum by day 28. The protective effect of ademetionine was manifested by a decrease in the contents of diene conjugates and malonic dialdehyde. There was a simultaneous activation of the glutathione system evident as increased activities of glutathione transferase and glutathione reductase. An antioxidant effect of cytoflavin was manifested mainly at the 1st wk of the experiment. The concentration of diene conjugates and malonic dialdehyde decreased, the activity of glutathione reductase increased, and the activity of glutathione transferase increased. Dihydroquercetin also had an antioxidant effect since the concentration of diene conjugates and malonic dialdehyde decreased. The activity of glutathione reductase and glutathione transferase increased. Conclusion. Sodium valproate significantly increased concentrations of lipid peroxidation products and impaired the glutathione antioxidant defense in the rat liver. Ademetionine, cytoflavin and dihydroquercetin help to restore the balance of lipid peroxidation and antioxidant protection in the rat liver during the toxic effects of valproate sodium. The most effective drug was ademetionine, since within 28 days, it significantly decreased the concentration of diene conjugates and malonic dialdehyde, and it increased the activity of the glutathione system.

Protective effect of chitooligosaccharides on hydrogen peroxide-induced PC-12 cells death by inhibition of oxidative damage

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Xueling Dai ◽  
Ping Chang ◽  
Ke Xu ◽  
Changjun Lin ◽  
Hanchang Huang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Pc 12 Cells ◽  
Cells Death
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