Chrysophyllum albidum mucilage as a binding agent in paracetamol tablet formulations

2016 ◽  
Vol 46 (6) ◽  
pp. 565-573 ◽  
Author(s):  
Tolulope O. Ajala ◽  
Olufunke D. Akin-Ajani ◽  
Chinemerem Ihuoma-Chidi ◽  
Oluwatoyin A. Odeku
Keyword(s):  
Binding Agent ◽  
Tablet Formulations ◽  
Paracetamol Tablet

scholarly journals Utilization of Pectin from Okra as Binding Agent in Immediate Release Tablets

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Frederick W. A. Owusu ◽  
Mariam E. Boakye-Gyasi ◽  
Philomena Entsie ◽  
Marcel T. Bayor ◽  
Kwabena Ofori-Kwakye
Keyword(s):  
Polymeric Materials ◽  
Immediate Release ◽  
Binding Agent ◽  
Crushing Strength ◽  
Binding Characteristics ◽  
Dissolution Tests ◽  
Potential Binding ◽  
Pharmaceutical Industries ◽  
Tablet Formulations ◽  
Paracetamol Tablet

Polymeric materials from plants continue to be of interest to pharmaceutical scientists as potential binders in immediate release tablets due to availability, sustainability, and constant supply to feed local pharmaceutical industries. Paracetamol tablet formulations were utilized in investigating the potential binding characteristics of pectin harnessed from various okra genotypes (PC1-PC5) in Ghana. The pectin yields from the different genotypes ranged from 6.12 to 18.84%w/w. The pH of extracted pectin ranged from 6.39 to 6.92, and it had good swelling indices and a low moisture content. Pectin extracted from all genotypes were evaluated as binders (10, 15, and 20%w/v) and compared to tragacanth BP. All formulated tablets (F1-F18) passed the weight uniformity, drug content, hardness, and friability tests. Based on their crushing strength, tablets prepared with pectin from the various genotypes were relatively harder ( P ≤ 0.05 ) than tablets prepared with tragacanth BP. Tablets prepared with pectins as binders at 10%w/v and 15%w/v passed the disintegration and dissolution tests with the exception of PC4 at 15%w/v. Incorporation of pectin from all genotypes (excluding PC5) as a binder at concentrations above 15%w/v (F13, F16, F14, and F15) produced tablets which failed the disintegration test and showed poor dissolution profiles. Thus, pectin from these genotypes can be industrially commodified as binders in immediate release tablets using varying concentrations.

scholarly journals Influence of process variables on release properties of paracetamol tablets

2007 ◽  
Vol 57 (1) ◽  
pp. 73-86 ◽  
Author(s):  
Gbenga Alebiowu ◽  
Oludele Itiola
Keyword(s):  
Interaction Effects ◽  
Process Variables ◽  
Factorial Experimental Design ◽  
Disintegration Time ◽  
Individual Effects ◽  
Pregelatinized Starch ◽  
Tablet Formulations ◽  
Binder Concentration ◽  
The Individual ◽  
Paracetamol Tablet

Influence of process variables on release properties of paracetamol tablets A 23 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e., N, c and d. In general, the most common ranking of the individual effects on DT, t1, t50 and t90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For interaction effects, the most common ranking was N-c > c-d > N-d for all formulations. The results generally showed that c can considerably affect DT, t1, t50 and t90 of the tablets.

scholarly journals Potential and Comparative Tablet Disintegrant Properties of Pectin Obtained from Five Okra Genotypes in Ghana

Scientifica ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Frederick William Akuffo Owusu ◽  
Mariam El Boakye-Gyasi ◽  
Jacob Kwaku Agbenorhevi ◽  
Marcel Tunkumgnen Bayor ◽  
Kwabena Ofori-Kwakye
Keyword(s):  
Immediate Release ◽  
Dissolution Profile ◽  
Maize Starch ◽  
Dissolution Tests ◽  
The World ◽  
Weight Test ◽  
Pharmaceutical Industries ◽  
Tablet Formulations ◽  
Low Levels ◽  
Paracetamol Tablet

Okra pectin has been studied as a potential excipient in tablet formulations for pharmaceutical industries. Okra is widely grown and available in Ghana and other parts of the world. The prospective use of pectin from okra genotypes grown in Ghana as tablet disintegrants has not been reported. This study aims to determine the potential and comparative disintegrating properties of pectin from five okra genotypes (Abelmoschus esculentus L.) in Ghana using uncoated immediate release paracetamol tablet formulations. The yield of the pectin from the various genotypes ranged between 6.12 and 18.84% w/w. The extracted pectins had pH ranging from slightly acidic to almost neutral (6.39–6.92). Pectin from the various genotypes exhibited good swelling indexes (˃200%), varying solubility in different solvents, and low moisture content (˂20%). Elemental analysis of the extracted pectin from the various genotypes revealed very low levels of toxic metals and micronutrients. Pectin from the various genotypes was evaluated as disintegrants within concentrations of 5–10% w/w (F1–F18). Their disintegrating properties were compared to that of maize starch BP. All the formulated batches of uncoated immediate release paracetamol tablets (F1–F18) passed the following: uniformity of weight test, uniformity of dimensions, hardness, friability (˂1%), and drug content (95–105%). Significant differences ( p ≤ 0.05 ) were observed between the hardness of the maize starch tablets and tablets formulated from pectin of the various genotypes. Pectin from all genotypes other than PC5 exhibited good disintegrating properties (DT ˂ 15 min) and subsequently passed the dissolution profile test (≥70% release in 45 minutes). Tablets formulated with PC5 as disintegrants at all concentrations (5% w/w (F5), 7.5% w/w (F11), and 10% w/w (F17)) failed the disintegration and dissolution tests. Ultimately, pectins extracted from PC1, PC2, PC3, and PC4 can be commercially exploited as disintegrants in immediate release tablets.

scholarly journals Evaluation of the Disintegrant Properties of Native Starches of Five New Cassava Varieties in Paracetamol Tablet Formulations

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Frank Kumah Adjei ◽  
Yaa Asantewaa Osei ◽  
Noble Kuntworbe ◽  
Kwabena Ofori-Kwakye
Keyword(s):  
Metal Ion ◽  
Toxic Metal ◽  
Immediate Release ◽  
Maize Starch ◽  
Flow Properties ◽  
Efficiency Ratio ◽  
Swelling Capacity ◽  
Tablet Formulations ◽  
Paracetamol Tablet ◽  
Cassava Varieties

The disintegrant potential of native starches of five new cassava (Manihot esculenta Crantz.) varieties developed by the Crops Research Institute of Ghana (CRIG) was studied in paracetamol tablet formulations. The yield of the starches ranged from 8.0 to 26.7%. The starches were basic (pH: 8.1–9.9), with satisfactory moisture content (≤15%), swelling capacity (≥20%), ash values (<1%), flow properties, and negligible toxic metal ion content, and compatible with the drug. The tensile strength (Ts), crushing strength (Cs), and friability (Ft) of tablets containing 5–10% w/w of the cassava starches were similar (p>0.05) to those containing maize starch BP. The disintegration times of the tablets decreased with increase in concentration of the cassava starches. The tablets passed the disintegration test (DT ≤ 15 min) and exhibited faster disintegration times (p>0.05) than those containing maize starch BP. The disintegration efficiency ratio (DER) and the disintegration parameter DERc of the tablets showed that cassava starches V20, V40, and V50 had better disintegrant activity than maize starch BP. The tablets passed the dissolution test for immediate release tablets (≥70% release in 45 min) with dissolution rates similar to those containing maize starch BP.

scholarly journals Evaluation of xerogels of cassava and cocoyam starches as dry granulation binders and disintegrants in directly compressed paracetamol tablet formulations

2019 ◽  
Author(s):  
Sylvester Okhuelegbe Eraga ◽  
Ogochukwu Augustina Meko ◽  
Magnus Amara Iwuagwu
Keyword(s):  
Flow Properties ◽  
Scanning Calorimetry ◽  
Disintegration Time ◽  
Dry Granulation ◽  
Standard Procedures ◽  
Wetting Time ◽  
Tablet Formulations ◽  
Tablet Manufacture ◽  
Paracetamol Tablet ◽  
Excipient Compatibility

The physicochemical properties of excipients play vital roles in the process of tablet manufacture. A comparative evaluation of the binding and disintegrant properties of xerogels of cassava and cocoyam starches with microcrystalline cellulose (MCC) in paracetamol tablet formulations was investigated. Cassava and cocoyam starches were extracted from their tubers following standard procedures. Xerogels of both starches were prepared and used to prepare batches of paracetamol granules for direct compression into tablets at concentrations of 3.8, 7.6 and 11.4 %w/w and with 7.6 %w/w MCC for comparison. Granules were analysed for their flow properties and drug-excipient compatibility and the tablets were evaluated for their tablets properties. The paracetamol granules prepared with the xerogel powders were comparable in flow properties with those made with MCC. Differential Scanning Calorimetry and Fourier Transform Infrared analyses revealed no interaction between the xerogel powders and paracetamol. Increase in concentrations of the xerogel powders led to an increase in hardness, wetting time, water sorption, disintegration time, drug release and a decrease in friability of the tablets. Tablets formulated with the starch xerogel powders met compendial requirements at 7.6 %w/w concentration. The study confirms the potentials of xerogels of cassava and cocoyam starches as dry granulation binders/disintegrants. Tablets made with the xerogel powders are superior to those made with MCC in terms of disintegration time but MCC produces harder and less friable tablets, as a superior binder.

Sign in / Sign up

Export Citation Format

Share Document