scholarly journals Influence of process variables on release properties of paracetamol tablets

2007 ◽  
Vol 57 (1) ◽  
pp. 73-86 ◽  
Author(s):  
Gbenga Alebiowu ◽  
Oludele Itiola
Keyword(s):  
Interaction Effects ◽  
Process Variables ◽  
Factorial Experimental Design ◽  
Disintegration Time ◽  
Individual Effects ◽  
Pregelatinized Starch ◽  
Tablet Formulations ◽  
Binder Concentration ◽  
The Individual ◽  
Paracetamol Tablet

Influence of process variables on release properties of paracetamol tablets A 23 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e., N, c and d. In general, the most common ranking of the individual effects on DT, t1, t50 and t90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For interaction effects, the most common ranking was N-c > c-d > N-d for all formulations. The results generally showed that c can considerably affect DT, t1, t50 and t90 of the tablets.

scholarly journals Evaluation of xerogels of cassava and cocoyam starches as dry granulation binders and disintegrants in directly compressed paracetamol tablet formulations

2019 ◽  
Author(s):  
Sylvester Okhuelegbe Eraga ◽  
Ogochukwu Augustina Meko ◽  
Magnus Amara Iwuagwu
Keyword(s):  
Flow Properties ◽  
Scanning Calorimetry ◽  
Disintegration Time ◽  
Dry Granulation ◽  
Standard Procedures ◽  
Wetting Time ◽  
Tablet Formulations ◽  
Tablet Manufacture ◽  
Paracetamol Tablet ◽  
Excipient Compatibility

The physicochemical properties of excipients play vital roles in the process of tablet manufacture. A comparative evaluation of the binding and disintegrant properties of xerogels of cassava and cocoyam starches with microcrystalline cellulose (MCC) in paracetamol tablet formulations was investigated. Cassava and cocoyam starches were extracted from their tubers following standard procedures. Xerogels of both starches were prepared and used to prepare batches of paracetamol granules for direct compression into tablets at concentrations of 3.8, 7.6 and 11.4 %w/w and with 7.6 %w/w MCC for comparison. Granules were analysed for their flow properties and drug-excipient compatibility and the tablets were evaluated for their tablets properties. The paracetamol granules prepared with the xerogel powders were comparable in flow properties with those made with MCC. Differential Scanning Calorimetry and Fourier Transform Infrared analyses revealed no interaction between the xerogel powders and paracetamol. Increase in concentrations of the xerogel powders led to an increase in hardness, wetting time, water sorption, disintegration time, drug release and a decrease in friability of the tablets. Tablets formulated with the starch xerogel powders met compendial requirements at 7.6 %w/w concentration. The study confirms the potentials of xerogels of cassava and cocoyam starches as dry granulation binders/disintegrants. Tablets made with the xerogel powders are superior to those made with MCC in terms of disintegration time but MCC produces harder and less friable tablets, as a superior binder.

An Evaluation of Dictyophora indusiata Mucilage as a Binder in Tablet Formulations

2021 ◽  
Vol 901 ◽  
pp. 22-27
Author(s):  
Kanokporn Burapapadh ◽  
Narumon Changsan ◽  
Chutima Sinsuebpol ◽  
Phennapha Saokham
Keyword(s):  
Research Work ◽  
Edible Mushroom ◽  
High Viscosity ◽  
Commercial Product ◽  
Drug Dissolution ◽  
Disintegration Time ◽  
Pharmaceutical Excipients ◽  
Tablet Formulations ◽  
Paracetamol Tablet

Dictyophora indusiata known as bamboo mushroom is an edible mushroom in Genus Dictyophora, Family Phallaceae that could produce highly viscous mucilage encased in the peridium. The viscous mucilage is clear-colorless hydrocolloid with high viscosity and high adhesive nature which made it possible to be developed into pharmaceutical excipients. This research work aimed at the application of the mucilage as a tablet binder. The mucilage was prepared as redispersible powder by lyphilization before used. The dried mucilage could be effectively used as a binder in paracetamol tablet formulations both as dry and wet binder. Increasing of the dried mucilage amount caused the stronger tablet with higher disintegration time. The optimum concentrations of the dried mucilage in tablet formulations were 2.0% w/w as dry binder and 1.0% w/w as wet binder. The obtained tablets revealed low friability and fast disintegration time. The drug dissolution was conformable to USP37 standard and comparable to that of commercial product. Accordingly, the Dictyophora indusiata mucilage could be functionally used as a tablet binder

scholarly journals Phytoremediation of nitrate contaminated water using ornamental plants

2019 ◽  
Vol 68 (8) ◽  
pp. 731-743 ◽  
Author(s):  
S. Shyamala ◽  
N. Arul Manikandan ◽  
Kannan Pakshirajan ◽  
Van Tai Tang ◽  
Eldon R. Rene ◽  
...  
Keyword(s):  
Removal Efficiency ◽  
Plant Density ◽  
Removal Rate ◽  
Nitrate Removal ◽  
Ornamental Plants ◽  
Growth Period ◽  
Interaction Effects ◽  
High Plant Density ◽  
Individual Effects ◽  
The Individual

Abstract This work aims at evaluating the potential of two ornamental plant species, i.e., money plant (Epiprennum aureum) and arrowhead plant (Syngonium podophyllum), to treat nitrate containing wastewater. Statistically designed experiments were performed to ascertain the effect of initial nitrate concentration (40–120 mg/L), growth period (1–12 days) and plant density (20–80 g/L) on nitrate removal. Based on the results of analysis of variance (ANOVA), it was observed that the individual effects (F = 78.04 and P = 0.013) of process parameters influenced the nitrate removal efficiency by money plant stronger than the 2-way (F = 0.2 and P = 0.89) and 3-way interaction effects (F = 0.46 and P = 0.569). In the case of the arrowhead plant, the individual effects significantly affected the nitrate removal efficiency than the 2-way and 3-way interaction effects. Low nitrate concentrations (40 mg/L) and high plant density (80 g/L), showed ∼88% nitrate removal by arrowhead plant, during a growth period of 6 d. On the contrary, under similar conditions, the money plant showed a nitrate removal efficiency of ∼93% during a growth period of 12 d. Concerning the removal kinetics, an increase in the growth period increased the nitrate removal rate for both the plants.

scholarly journals Effects of Water Yam and Corn Starches on the Interacting Variables Influencing the Disintegration of Chloroquine Phosphate Tablets

2012 ◽  
Vol 10 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Adenike Okunlola ◽  
Oluwatoyin A Odeku
Keyword(s):  
Relative Density ◽  
Corn Starch ◽  
Interaction Coefficient ◽  
Dissolution Time ◽  
Factorial Experimental Design ◽  
Disintegration Time ◽  
Crushing Strength ◽  
The Individual ◽  
High Level ◽  
Water Yam

The individual and effects of interaction of nature (X) and concentration (Y) of disintegrant and the relative density (Z) on the mechanical and release properties of chloroquine phosphate tablets were studied using a 23 factorial experimental design. Water yam starch (“low” level) and corn starch (“high” level) were used as disintegrants at concentrations of 5.0% and 20.0% w/w. The mechanical properties were assessed using the crushing strength (CS) and friability (F) and the release properties by the disintegration time (DT) and dissolution time (t80). Increasing the concentration of disintegrants and the relative density of tablets resulted in increase in CS, but decrease in F, DT and t80. The ranking of the individual coefficient values was Z >X >Y for CS, Z > X>Y for F and DT, and Y>X>Z for t80 while that for the interaction coefficient was X-Z> Y-Z > X-Y for CS, Y-Z> X-Z > X-Y for F, Y-Z> X-Y> X-Z for DT and t80. Changing the disintegrant from corn starch to water yam starch resulted in decrease in CS, DT and t80 but increase in F. The results showed considerable interaction between the variables employed and suggested that water yam could be an alternative disintegrant to corn starch particularly where faster disintegration and release are required. DOI: http://dx.doi.org/10.3329/dujps.v10i1.10011 DUJPS 2011; 10(1): 21-28

scholarly journals Evaluation of super-disintegrant potential of acid-modified starch derived from Borassus aethiopum (Aracaceae) shoot in paracetamol tablet formulations

2020 ◽  
Vol 19 (3) ◽  
pp. 459-465
Author(s):  
Chukwuemeka P. Azubuike ◽  
Uloma N. Ubani-Ukoma ◽  
Abiola R. Afolabi ◽  
Ibilola M. Cardoso-Daodu
Keyword(s):  
Low Cost ◽  
Wet Granulation ◽  
Modified Starch ◽  
Disintegration Time ◽  
Sodium Starch Glycolate ◽  
Tablet Formulations ◽  
Ftir Spectrophotometry ◽  
Borassus Aethiopum ◽  
Expected Increase ◽  
Paracetamol Tablet

Purpose: To evaluate the super-disintegrant potentials of acid modified Borassus aethiopum starch (AMS) in comparison with native starch (NS) and commercial disintegrant sodium starch glycolate (SSG). Methods: Compatibility of AMS with paracetamol powder was evaluated using Fourier transform infrared (FTIR) spectrophotometry. Seven batches of paracetamol granules and tablets were prepared by wet granulation. AMS and NS were employed as disintegrants at concentrations of 2.43, 4.86 and 9.72 %w/w, respectively while 4.86 %w/w SSG was used as standard disintegrant. All the batches of the granules were compressed under the same compression settings. The properties of the granules as well as those of the tablets were assessed. Results: AMS was compatible with paracetamol powder as no noticeable interaction was observed in FTIR study. The paracetamol tablets formulated using AMS as disintegrant demonstrated satisfactory friability, weight uniformity, hardness, and superior disintegration characteristics to the formulations containing NS and SSG as disintegrant. Even at a lower concentration (2.43 %w/w), AMS possessed better disintegrant property than NS and SSG. AMS and NS had dimensionless disintegrant quantity of 1.447 and 0.005, respectively. As expected, increase in AMS concentration showed a decrease in disintegration time. Conclusion: AMS could be a potential low-cost super-disintegrant in formulation of paracetamol tablets. Keywords: Acid modified starch, Borassus aethiopum, Disintegrant, Compatibility

scholarly journals Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations

2014 ◽  
Vol 27 (3) ◽  
pp. 187-194 ◽  
Author(s):  
Musiliu O. Adedokun ◽  
John O. Ayorinde ◽  
Michael A. Odeniyi
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Binding Properties ◽  
Crushing Strength ◽  
Density Measurements ◽  
Pharmaceutical Tablets ◽  
Compression Properties ◽  
Tablet Formulations ◽  
Binder Concentration ◽  
Paracetamol Tablet

ABSTRACT The binding properties of Eucalyptus gum obtained from the incised trunk of Eucalyptus tereticornis, were evaluated in paracetamol tablet formulations, in comparison with that of Gelatin B.P. In so doing, the compression properties were analyzed using density measurements and the compression equations of Heckel, Kawakita and Gurham. In our work, the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets, while the drug release properties of the tablets were assessed using disintegration and dissolution times. The results of the study reveal that tablet formulations incorporating Eucalyptus gum as binder, exhibited faster onset and higher amount of plastic deformation during compression than those containing gelatin. What is more, the Gurnham equation could be used as a substitute for the Kawakita equation in describing the compression properties of pharmaceutical tablets. Furthermore, the crushing strength, disintegration and dissolution times of the tablets increased with binder concentration, while friability values decreased. We noted that no significant differences in properties exist between formulations derived from the two binders (p > 0.05) exist. While tablets incorporating gelatin exhibited higher values for mechanical properties, Eucalyptus gum tablets had better balance between mechanical and release properties - as seen from the CSFR/Dt values. Tablets of good mechanical and release properties were prepared using Eucalyptus gum as a binder, and, therefore, it could serve as an alternative binder in producing tablets with good mechanical strength and fast drug release.

Evaluation of the Direct Compression Properties of Microcrystalline Cellulose Obtained from Cassava Fermentation Waste in Paracetamol Tablet Formulations

2020 ◽  
Vol 16 (1) ◽  
pp. 31-37
Author(s):  
S.O. Eraga ◽  
D.N. Elue ◽  
M.A. Iwuagwu
Keyword(s):  
Microcrystalline Cellulose ◽  
Comparative Evaluation ◽  
Local Source ◽  
Direct Compression ◽  
Disintegration Time ◽  
Compression Properties ◽  
Tablet Properties ◽  
Test Specification ◽  
Tablet Formulations ◽  
Paracetamol Tablet

Background: Natural materials have gained a lot of significance in the field of drug delivery because of their cost effectiveness and ready availability.Purpose: The study aimed at evaluating the direct compression property of microcrystalline cellulose from cassava fermentation waste in directly compressed paracetamol tablet formulations.Methods: Alkali delignification of the dried cassava fermentation fibres, followed by bleaching and acid depolymerisation was employed in the extraction of α-cellulose and conversion to microcrystalline cellulose (MCC). The MCC obtained and Avicel® were used at different concentrations (5.0-15 %w/w) to formulate batches of paracetamol tablets by directed compression. A comparative evaluation of the formulated paracetamol granules and tablets properties were undertaken.Results: The paracetamol granules formulated showed good flowability with Hausner’s ratios of 1.15-1.25, Carr’s indices of 13.10-20.00 % and angles of repose ≤ 34.41°. The formulated tablets showed good hardness (> 5.0 kgf) and disintegration time within 10 min. Only tablets containing 5.0 and 7.5 %w/w of the test MCC failed the BP dissolution test specification for tablets which stipulates that at least 70 % of the drug should be in solution after 30 min.Conclusion: This study has shown that the extracted MCC has direct compression ability evidenced in the mechanical strength of the formulated paracetamol tablets. The tablet properties of the formulated paracetamol tablets revealed pharmaceutically acceptable tablets though they were not comparable with Avicel® at all concentrations and the MCC may serve as an alternative local source for direct compression excipient. Keywords: Cassava, microcrystalline cellulose, direct compression, paracetamol, tablets

scholarly journals DESIGN, OPTIMIZATION AND EVALUATION OF CETRIZINE DIHYDROCHLORIDE FAST DISSOLVING FILMS EMPLOYING STARCH TARTRATE–A NOVEL SUPERDISINTEGRANT

2019 ◽  
pp. 75-86
Author(s):  
R. SANTOSH KUMAR ◽  
ANNU KUMARI ◽  
B. KUSUMA LATHA ◽  
PRUDHVI RAJ
Keyword(s):  
Tensile Strength ◽  
Drug Dissolution ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
Scanning Calorimetry ◽  
Disintegration Time ◽  
Folding Endurance ◽  
Contour Plots ◽  
The Individual

Objective: The aim of the current research is optimization, preparation and evaluation of starch tartrate (novel super disintegrant) and preparation of fast dissolving oral films of cetirizine dihydrochloride by employing starch tartrate. Methods: To check the drug excipient compatibility studies of the selected drug (Cetrizine dihydrochloride) and the prepared excipient i. e starch tartrate, different studies like FTIR (Fourier-transform infrared spectroscopy), DSC (Differential scanning calorimetry) and thin-layer chromatography (TLC) were carried out to find out whether there is any interaction between cetirizine dihydrochloride and starch tartrate. The solvent casting method was used for the preparation of fast dissolving films. The prepared films were then evaluated for thickness, folding endurance, content uniformity, tensile strength, percent elongation, in vitro disintegration time and in-vitro dissolution studies. Response surface plots and contour plots were also plotted to know the individual and combined effect of starch tartrate (A), croscarmellose sodium (B) and crospovidone (C) on disintegration time and drug dissolution efficiency in 10 min (dependent variables). Results: Films of all the formulations are of good quality, smooth and elegant by appearance. Drug content (100±5%), thickness (0.059 mm to 0.061 mm), the weight of films varies from 51.33 to 58.06 mg, folding endurance (52 to 67 times), tensile strength (10.25 to 12.08 N/mm2). Fast dissolving films were found to disintegrate between 34 to 69 sec. Percent dissolved in 5 min were found to be more in F1 formulation which confirms that starch tartrate was effective at 1%. Conclusion: From the research conducted, it was proved that starch tartrate can be used in the formulation of fast dissolving films of cetirizine dihydrochloride. The disintegration time of the films was increased with increase in concentration of super disintegrant.

ALTERNATIVE ROUTES TO INNOVATION — THE EFFECTS OF CULTURAL AND STRUCTURAL FIT

2019 ◽  
Vol 24 (01) ◽  
pp. 2050006
Author(s):  
DAG INGVAR JACOBSEN ◽  
TORE HILLESTAD ◽  
BIRGITTE YTTRI ◽  
JARLE HILDRUM
Keyword(s):  
Response Rate ◽  
Organic Structure ◽  
Configurational Approach ◽  
Culture Strength ◽  
Individual Effects ◽  
Collective Phenomenon ◽  
The Individual ◽  
Alternative Routes ◽  
Innovative Culture ◽  
The Empirical Analysis

A configurational approach to organizations assumes that structural and cultural characteristics must be in “fit” to produce the wanted outcome. With a focus on innovation, this study examines empirically to what extent innovative activities with a large, global telecom company are produced by an innovative culture, an innovative structure, as well as the fit between the two. Based on an extensive survey (N = 21064, response rate = 65) of employees in seven countries in Europe and Asia, data was aggregated to unit level as culture by nature is a collective phenomenon. The empirical analysis detected both the individual effects of culture strength and homogeneity, structure, as well as the fit between the two. The results indicate that an innovative culture and an organic structure indeed fosters innovation, but that, somewhat surprisingly, there are not effects of the fit between the two. Both practical and theoretical implications are discussed.

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