scholarly journals A Phase 4, Open-Label, Single-Arm Study Assessing the Efficacy and Safety of Ivabradine in African American Patients with Heart Failure and Reduced Ejection Fraction

2020 ◽  
Vol 9 (2) ◽  
pp. 561-568
Author(s):  
David E. Lanfear ◽  
Kelsey R. Neaton ◽  
Chen Lu ◽  
Yimeng Liu ◽  
Ricardo E. Dent-Acosta
Keyword(s):  
Heart Failure ◽  
African American ◽  
Ejection Fraction ◽  
Efficacy And Safety ◽  
Open Label ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

scholarly journals Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction　― The CIBIS-J Trial ―

2019 ◽  
Vol 83 (6) ◽  
pp. 1269-1277
Author(s):  
Hiroyuki Tsutsui ◽  
Shin-ichi Momomura ◽  
Tohru Masuyama ◽  
Yoshihiko Saito ◽  
Issei Komuro ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Japanese Patients ◽  
Efficacy And Safety ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

scholarly journals Efficacy and Safety of Different Aerobic Exercise Intensities in Patients With Heart Failure With Reduced Ejection Fraction: Design of a Multicenter Randomized Controlled Trial (HF-EI Trial)

2021 ◽  
Vol 8 ◽  
Author(s):  
Ting Shen ◽  
Xiaoling Liu ◽  
Bo Zhuang ◽  
Qian Luo ◽  
Yishan Jin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Aerobic Exercise ◽  
Exercise Intensity ◽  
Control Group ◽  
Efficacy And Safety ◽  
Reduced Ejection Fraction ◽  
Clinical Events ◽  
Patients With Heart Failure ◽  
Intensity Training

Background: Heart failure (HF) is one of the major causes of mortality worldwide, representing the terminal stage of several cardiovascular diseases. Exercise-based rehabilitation is a beneficial therapy for patients with chronic heart failure (CHF). However, there is a lack of specific guidance on clinical decision-making regarding optimal exercise intensity. It is necessary to optimize the clinical recommendations for HF exercises. We will evaluate the efficacy and safety of different aerobic exercise intensities in patients with heart failure with reduced ejection fraction (HFrEF): the HF-EI trial. This trial aims to assess the appropriate exercise intensity for patients with HFrEF.Methods: After a baseline assessment to determine the safety of exercise, 180 patients will be randomly assigned to supervised high-intensity exercise training (ET) group, supervised moderate intensity training (MIT) group, and control group at a ratio of 1:1:1. Patients randomly receiving high intensity training (HIT) undergo supervised ET (3 times/week, 30 min) for aerobic endurance at 70% peak oxygen consumption (peak VO2) intensity for 12 weeks. The MIT patients will perform supervised aerobic ET (3 times/week, 35–42 min) at the anaerobic threshold (AT) intensity for 12 weeks. The control group will continue to maintain their daily activities and will not receive ET. During the baseline and follow-up period, physical examination, laboratory tests, cardiology diagnostic tests, cardiopulmonary exercise tests (CPET), 6-min walk distance (6MWD), scale scores, exercise steps, medications, and clinical events will be monitored. Throughout the research, sport bracelets and patient diaries will be used to monitor and record overall physical activity, training courses, and compliance.Discussion: The HF-EI trial will evaluate the effects of different aerobic exercise intensities on peak VO2, quality of life (QoL), and clinical events among patients with HFrEF. The findings of this trial will provide a basis for formulating exercise prescriptions for patients with HFrEF.Clinical Trial Registration:http://www.chictr.org.cn/, identifier: ChiCTR2000036381.

Efficacy and Safety of Ivabradine in an Elderly Patient with Heart Failure with Reduced Ejection Fraction

2021 ◽  
Vol 41 (2) ◽  
pp. 193-196
Author(s):  
Shunsuke Kiuchi ◽  
Shinji Hisatake ◽  
Takayuki Kabuki ◽  
Takashi Oka ◽  
Takahiro Fujii ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patient ◽  
Ejection Fraction ◽  
Efficacy And Safety ◽  
Reduced Ejection Fraction
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