Choriocapillaris Vascular Density Changes in Patients with Drusen: Cross-Sectional Study Based on Optical Coherence Tomography Angiography Findings

Abstract Purpose To measure optic nerve head (ONH) blood perfusion using optical coherence tomography angiography (OCTA) at various stages of diabetic retinopathy (DR). Methods One hundred seventy six eyes of 94 patients included in this retrospective single-centre cross-sectional study. The subjects were studied in normal, no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative retinopathy (PDR) groups. The eyes were subjected to AngioDisc ONH imaging using OCTA for papillary (Disc) and peripapillary (RPC) vascular density (VD) evaluation. Results The mean age of the participants was 56.08 ± 8.87 years and 34 (36.2 percent) were male. With increased DR severity, a statistically significant decrease in peripapillary VD was found. The study showed that only VD of the whole RPC (W-RPC) could be a valid biomarker in the staging assessment. VD of RPC, in all subsections, was considerably different from normal cases in the PDR group. Visual acuity was correlated with whole image ONH VD. The duration of DM, FBS, hyperlipidemia and DME had no effect on the ONH perfusion. Conclusions The study showed that only the W-RPC VD could be a reasonable marker in the staging assessment. VDs assessed by OCTA can be useful for assessing and tracking early ONH changes in DR patients.

Download Full-text

Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-312401 ◽

2018 ◽

Vol 103 (7) ◽

pp. 949-954 ◽

Cited By ~ 10

Author(s):

Jayasree P Venugopal ◽

Harsha Laxmana Rao ◽

Robert N Weinreb ◽

Srilakshmi Dasari ◽

Mohammed Riyazuddin ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Cross Sectional Study ◽

High Density ◽

Vessel Density ◽

Optical Coherence ◽

Sectional Study ◽

Limits Of Agreement ◽

Cross Sectional ◽

The Mean

AimsTo compare the peripapillary vessel density (VD) measurements of high-density (HD) and non-HD optical coherence tomography angiography (OCTA) scans in normal and glaucoma eyes, and to evaluate the intrasession repeatability of VD measurements of HD scans.MethodsIn a cross-sectional study, 46 normal (33 subjects) and 89 glaucoma (64 patients) eyes underwent 3 HD and 1 non-HD optic nerve head OCTA scans in the same session. Agreement in VD measurements between HD and non-HD scans was assessed using Bland and Altman analysis. Repeatability of the VD measurements of HD scans was assessed using within-subject coefficient of repeatability (CRw) and variation (CVw).ResultsThe mean difference in the VDs ranged between 0.7% (temporal sector VD) and 2.0% (inferonasal sector VD), with HD scans showing significantly greater VD values than non-HD scans. The 95% limits of agreement (LoA) in glaucoma eyes ranged between −2.0% and 5.0% for whole enface VD and between −4.8% and 9.6% for superotemporal VD. CRw (%) and CVw (%) of VD measurements of HD scans ranged from 3.0 to 4.9 and from 2.0 to 3.1 in normal eyes. The same ranged from 3.2 to 6.7 and from 2.6 to 4.8, respectively, in glaucoma eyes.ConclusionsVD of HD scans was higher than that of non-HD scans. The wide 95% LoA indicates that the VD measurements of HD and non-HD scans cannot be used interchangeably. Test–retest repeatability of VDs on HD scans was as high as 6%. These results should be considered while using OCTA for longitudinal evaluation of glaucoma.

Download Full-text

Prospective Cross-Sectional Study of Repeatability of Peripapillary Capillary Density Measurement Using Optical Coherence Tomography Angiography in Eyes With Optic Nerve and Retinal Vascular Pathology

Journal of Neuro-Ophthalmology ◽

10.1097/wno.0000000000001216 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Alexander F. Vu ◽

Susan A. Alber ◽

Melinda Y. Chang ◽

Susanna S. Park

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optical Coherence Tomography Angiography ◽

Density Measurement ◽

Capillary Density ◽

Cross Sectional Study ◽

Vascular Pathology ◽

Optical Coherence ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults

Journal of Ophthalmology ◽

10.1155/2017/1397179 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Shiqi Yang ◽

Minwen Zhou ◽

Bing Lu ◽

Pengfei Zhang ◽

Jingke Zhao ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Young Adults ◽

High Myopia ◽

Optical Coherence Tomography Angiography ◽

Retinal Thickness ◽

Cross Sectional Study ◽

Vascular Density ◽

Ganglion Cell Complex ◽

Optical Coherence ◽

Cross Sectional

Purpose. To quantify macular vascular density using optical coherence tomography angiography (OCTA) and to investigate its relationship with retinal thickness in myopic eyes of young adults.Methods. In this cross-sectional study, 268 myopic eyes without pathological changes were recruited and divided into three groups: mild myopia (n=81), moderate myopia (n=117), and high myopia (n=70). Macular vascular density was quantified by OCTA and compared among three groups. Average retinal thickness, central subfield thickness, and macular ganglion cell complex (mGCC) thickness were also evaluated and compared. Correlations among these variables were analyzed.Results. There was no statistical difference in superficial (62.3 ± 5.7% versus 62.7 ± 5.9% versus 63.8 ± 5.5%) and deep macular vascular densities (58.3 ± 9.6% versus 59.2 ± 9.3% versus 60.9 ± 7.9%) among mild-myopia, moderate-myopia, and high-myopia groups (bothP>0.05). Superficial and deep macular vascular densities both had correlations with mean arterial pressure. Furthermore, superficial macular vascular density was significantly correlated with mGCC thickness.Conclusions. Varying degrees of myopia did not affect macular vascular density in young healthy adults. In addition, superficial macular vascular density, as an independent factor, was positively correlated with mGCC thickness.

Download Full-text

Optical coherence tomography angiography features of macular neovascularization in wet age-related macular degeneration: A cross-sectional study

Annals of Medicine and Surgery ◽

10.1016/j.amsu.2021.102826 ◽

2021 ◽

Vol 70 ◽

pp. 102826

Author(s):

Mahjoub Ahmed ◽

Ben Mrad Syrine ◽

Ben Abdesslem Nadia ◽

Mahjoub Anis ◽

Zinelabidine Karim ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Degeneration ◽

Optical Coherence Tomography Angiography ◽

Cross Sectional Study ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Sectional Study ◽

Cross Sectional ◽

Age Related

Download Full-text

Optical coherence tomography angiography in multiple sclerosis: A cross-sectional study

PLoS ONE ◽

10.1371/journal.pone.0236090 ◽

2020 ◽

Vol 15 (7) ◽

pp. e0236090

Author(s):

Roberta Farci ◽

Arturo Carta ◽

Eleonora Cocco ◽

Jessica Frau ◽

Maurizio Fossarello ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Cross Sectional Study ◽

Optical Coherence ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems

Journal of Ophthalmology ◽

10.1155/2019/4372580 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Jingyuan Yang ◽

Mingzhen Yuan ◽

Erqian Wang ◽

Youxin Chen

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Vessel Density ◽

Vascular Density ◽

Optical Coherence ◽

Cross Sectional ◽

Capillary Plexus ◽

Scan Pattern

The aim of this study was to compare the repeatability of optical coherence tomography angiography (OCT-A) measurements of macular vessel density using four OCT-A systems, including Heidelberg Spectralis HRA, Optovue RTVue XR, Zeiss Cirrus HD-OCT 5000, and Topcon DRI OCT Triton. A cross-sectional design was used for this study. The vascular density and vascular length density of the superficial and deep retinal capillary plexuses were imaged with OCT-A using 3 mm and 6 mm scan patterns and were calculated using ImageJ. Comparisons of intraclass correlation coefficients (ICC) were conducted. We found that the OCT-A systems had various levels of repeatability. Zeiss had better repeatability for vessel density than the other systems (overall ICC = 0.936). Optovue had better repeatability for vessel length density when the 6 mm scan pattern was used (ICC = 0.680 and 0.700 for retinal superficial and deep capillary plexus, respectively). We concluded that repeatability varied when different scan patterns of various OCT-A systems were used for imaging the superficial retinal and deep capillary plexuses. Results should be seen as valid only for a given method. The repeatability of various OCT-A systems should be considered in clinical practice and in clinical trials that use OCT-A metrics as outcome measures.

Download Full-text

Conjunctival structure of glaucomatous eyes treated with anti-glaucoma eye drops: a cross-sectional study using anterior segment optical coherence tomography

BMC Ophthalmology ◽

10.1186/s12886-020-01518-6 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Makoto Gozawa ◽

Yoshihiro Takamura ◽

Kentaro Iwasaki ◽

Shogo Arimura ◽

Masaru Inatani

Keyword(s):

Optical Coherence Tomography ◽

Anterior Segment ◽

Cross Sectional Study ◽

Eye Drops ◽

Optical Coherence ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Repeatability of vessel density measurements of optical coherence tomography angiography in normal and glaucoma eyes

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2017-310637 ◽

2017 ◽

Vol 102 (3) ◽

pp. 352-357 ◽

Cited By ~ 55

Author(s):

Jayasree P Venugopal ◽

Harsha L Rao ◽

Robert N Weinreb ◽

Zia S Pradhan ◽

Srilakshmi Dasari ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Repeated Measures ◽

Optical Coherence Tomography Angiography ◽

Signal Strength ◽

Cross Sectional Study ◽

Vessel Density ◽

Optical Coherence ◽

Cross Sectional ◽

Density Measurements ◽

Density Values

AimsTo compare the intrasession repeatability of peripapillary and macular vessel density measurements of optical coherence tomography angiography (OCTA) in normal and glaucoma eyes, and to evaluate the effect of signal strength of OCTA scans on the repeatability.MethodsIn a cross-sectional study, three optic nerve head scans each of 65 eyes (30 normal, 35 glaucoma eyes) and three macular scans each of 69 eyes (35 normal, 34 glaucoma eyes) acquired in the same session with OCTA were analysed. Repeatability was assessed using within-subject coefficient of repeatability (CRw) and variation (CVw). Effect of signal strength index (SSI) on repeatability was evaluated with repeated-measures mixed-effects models.ResultsCRw (%) and CVw (%) of peripapillary measurements in normal eyes ranged between 3.3 and 7.0, and 2.5 and 4.4 respectively, and that in glaucoma eyes between 3.5 and 7.1, and 2.6 and 6.6. For the macular, these measurements ranged between 4.1 and 6.0, and 3.3 and 4.7 in normal eyes and 4.3 and 6.9, and 3.7 and 5.6 in glaucoma eyes. Repeatability estimates of most measurements were similar in normal and glaucoma eyes. Vessel densities of both peripapillary and macular regions significantly increased with increase in SSI of repeat scans (coefficients ranging from 0.15 to 0.38, p<0.01 for all associations).ConclusionsRepeatability estimates of OCTA measured peripapillary and macular vessel densities were similar in normal eyes and eyes with glaucoma. SSI values of the scans had a significant effect on the repeatability of OCTA with the vessel density values increasing in scans with higher SSI values.

Download Full-text