The Efficacy and Safety of YAG Laser Vitreolysis for Symptomatic Vitreous Floaters of Complete PVD or Non-PVD

Objective To examine the efficacy and safety of yttrium-aluminium garnet (YAG) laser vitreolysis for the treatment of vitreous floaters. Methods Consecutive adult patients with symptomatic vitreous floaters who attended Chongqing General Hospital from April to December 2016 were included in this prospective study. Patients had >3 mm between the vitreous opacity and retina/lens and acceptable quality peri-papillary Optical Coherence Tomography (OCT) images (i.e., signal strength ≥5). Those with history of glaucoma, severe cataracts, vitreous haemorrhages, retinal holes and/or macular disease were excluded from the study. Best corrected visual acuity (BCVA) and non-contact intraocular pressure (IOP) were measured before and for up to 6 months post-YAG laser vitreolysis. Anterior segment photography and peripapillary retinal nerve fibre layer (RNFL) measured by OCT were taken before and 6 months post-procedure. Questionnaires on patient satisfaction were completed 6 months post-procedure. Results No statistically significant differences in BCVA and IOP were observed before or after treatment. Anterior segment photography showed that vitreous opacities partially or completely disappeared after YAG laser treatment. The thickness of RNFL in four directions (upper, below, nasal and temporal) was not statistically significant different before or 6 months after the procedure. 75% patients reported significant improvement and 25% reported moderate improvement. Conclusion The results of this study conducted in a cohort of 30 Chinese patients showed that YAG laser vitreolysis was a well-tolerated and effective treatment for vitreous floaters. Randomised, controlled trials involving large numbers of participants monitored over an extended follow up period are required to confirm these results.

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Efficacy and safety of Nd:YAG laser vitreolysis for symptomatic vitreous floaters: A randomized controlled trial

European Journal of Ophthalmology ◽

10.1177/1120672120968762 ◽

2020 ◽

pp. 112067212096876

Author(s):

Gustavo D Ludwig ◽

Henrique Gemelli ◽

Guilherme M Nunes ◽

Pedro D Serracarbassa ◽

Márgara Zanotele

Keyword(s):

Adverse Events ◽

Contrast Sensitivity ◽

Nd:Yag Laser ◽

Visual Disturbance ◽

Control Group ◽

Efficacy And Safety ◽

Yag Laser ◽

Vitreous Floaters ◽

Significant Difference ◽

Laser Group

Background: Vitreous floaters are a common and inconvenient phenomena. This study aims to examine the efficacy and safety in treating vitreous floaters using Nd:YAG laser vitreolysis. Methods: In this prospective double-blinded randomized clinical trial 24 eyes of twenty-four patients were randomized into intervention with YAG laser vitreolysis and control groups. Primary outcomes were visual disturbance on a 10-point scale, qualitative changes in a 4-level scale, contrast sensitivity measured with the Pelli-Robson table and the National Eye Institute Visual Functioning Questionnaire 25 (NEI VFQ-25). Secondary results included objective change in vitreous opacities, best-corrected visual acuity (BCVA), variation in intraocular pressure (IOP) and other adverse events. Results: Twenty-one patients (21 eyes; 5 male, 16 female) were enrolled in this study (mean age 62 ± 7.9 years), three were lost during follow-up. In the YAG laser group, the 10-point visual disturbance score improved a mean of 4.7 points ( p < 0.001) compared to the control group that improved 2.1 ( p = 0.09). The YAG laser group reported greater subjectively symptomatic improvement (77%) than controls (25%). NEI VFQ-25 revealed improved general vision (75.8 versus 59.2; p = 0.037) and in mental health at 6 months (84.3 versus 70.3; p = 0.048). There was no significant difference in contrast sensitivity ( p = 0.848) and in IOP ( p = 0.505). No differences in adverse events between groups were identified. Conclusion: Vitreolysis with Nd:YAG laser improves visual results in patients with symptomatic vitreous floaters, without adverse events considered clinically relevant. Other trials with a larger number of participants are required to corroborate these results.

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Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser Therapy for Pigmented Skin Lesions: Efficacy and Safety

Kathmandu University Medical Journal ◽

10.3126/kumj.v10i2.7343 ◽

2013 ◽

Vol 10 (2) ◽

pp. 46-50 ◽

Cited By ~ 2

Author(s):

D Karn ◽

S KC ◽

A Amatya ◽

EA Razouria ◽

M Timalsina ◽

...

Keyword(s):

Recurrence Rate ◽

Safety Profile ◽

Yttrium Aluminum Garnet ◽

Skin Lesions ◽

University Hospital ◽

Efficacy And Safety ◽

Yag Laser ◽

Pigmentary Disorders ◽

Yttrium Aluminum ◽

Pigmented Skin Lesions

Background Nepalese population with Fitzpatrick skin types III-V has high prevalence of pigmentary disorders and it is a growing cosmetic concern. Q-Switched Neodymium- Doped Yttrium Aluminum Garnet (QS Nd-YAG) laser is an efficacious tool in the treatment of pigment disorders. Objective To highlight the efficacy and safety profile of various pigment disorders. Methods A prospective study done in Dhulikhel Hospital, Kathmandu University Hospital from January 2009 to January 2011. Patients undergoing laser for pigmented skin lesions were followed for response and safety profile. We included total 270 patients in the study with various disorders especially nevus, tattoos and melasma. Settings were repeated at 3-4 weeks interval and response was evaluated on clinical basis. Efficacy was then evaluated according to various parameters. Results For nevus, total 840 treatment sessions had been performed with an average of 6.88 sessions (range 3-11). Nd: YAG laser was very efficacious in removal of blue and black colored tattoos with an average of 7.9 and 9.5 sessions respectively. However, red mixed with blue and or green tattoos were relatively resistant to treatment and required average 10.33 treatment sessions. Melasma and freckles both responded to the therapy but recurrence rate was high. Conclusion Our results indicate that QS Nd: YAG laser is an effective modality for pigment disorders among Nepalese population. Nevus and melasma respond well but recurrence rate of melasma is high. Blue tattoos respond well while mixed colored tattoos are quite resistant to Nd: YAG laser alone. Transient pain and temporary hyperpigmentation are common side effects. Kathmandu University Medical Journal | Vol.10 | No. 2 | Issue 38 | Apr – June 2012 | Page 46-50 DOI: http://dx.doi.org/10.3126/kumj.v10i2.7343

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Objective intraoperative assessment of vitreous f loaters localization in YAG-laser vitreolysis

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-3-258-261 ◽

2021 ◽

pp. 258-261

Author(s):

B.A. Normaev ◽

◽

A.V. Doga ◽

D.A. Buryakov ◽

◽

...

Keyword(s):

Optical Method ◽

Vitreous Cavity ◽

Optical Methods ◽

Safe Distance ◽

Limits Of Agreement ◽

Yag Laser ◽

Vitreous Floaters ◽

Measurement Results ◽

Key Word ◽

Ultrasound Assessment

Purpose. To develop an optical method for assessing the localization of vitreous floaters in the vitreous cavity and to evaluate its efficacy compared to ultrasound assessment. Material and methods. The study included 35 patients (35 eyes) with Weiss ring. All the patients underwent echobiometry, as well as measurement of the distance from the vitreous floaters (VF) to the lens posterior capsule or towards retina by ultrasound and developed optical methods. Results. The mathematical modeling and the diopter difference between the slit-lamp oculars were used to develop a formula for the safe position of the VF in the vitreous cavity calculation. A comparative analysis of ultrasound and optical methods measurement results have showed their comparability. The values of the "limits of agreement" with 95% confidence intervals were: -0.02 [-0.07; 0.01] - the lower "consistency limit" and 0.25 [0.20; 0.29] - the upper "consistency limit". The average difference between methods with a 95% confidence interval was 0.11 [0.08; 0.13]. Conclusions. The developed optical method for assessing the safe localization of VF in the vitreous cavity showed comparable results with the ultrasound measurements. Futhermore, optical method allows to intraoperatively control the safe distance from the VF to the intraocular structures, thereby reducing the risk of YAG-vitreolysis complications. Key word: YAG laser vitreolysis, vitreous floaters, safe distance of vitreous floaters.

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Safety and Efficacy of YAG Laser Vitreolysis for the Treatment of Vitreous Floaters: An Overview

Advances in Therapy ◽

10.1007/s12325-020-01261-w ◽

2020 ◽

Vol 37 (4) ◽

pp. 1319-1327 ◽

Cited By ~ 1

Author(s):

Andreas Katsanos ◽

Nikoleta Tsaldari ◽

Konstantina Gorgoli ◽

Fotios Lalos ◽

Maria Stefaniotou ◽

...

Keyword(s):

Safety And Efficacy ◽

Yag Laser ◽

Vitreous Floaters

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Comparison of effects of 5% hydroquinone cream plus non-ablative fractional 1540 erbium YAG laser and 5% hydroquinone cream alone in the treatment of melasma

Medical Journal of Tabriz University of Medical Sciences and Health Services ◽

10.34172/mj.2021.024 ◽

2021 ◽

Vol 43 (1) ◽

pp. 29-34

Author(s):

Mohammadreza Ranjkesh ◽

Sanay Azizifard ◽

Hamideh Azimi alamdari ◽

Neda Ghorbani Khosroshahi

Keyword(s):

Sample Size ◽

Laser Therapy ◽

Severity Index ◽

Monthly Interval ◽

Study Group ◽

Efficacy And Safety ◽

Yag Laser ◽

Group 2 ◽

Larger Sample ◽

Group 1

Background: Melasma is an acquired Hypermelanosis often difficult to treat. In this study, we assessed efficacy and safety of 5% hydroquinone cream plus non-ablative fractional 1540 erbium YAG laser and 5% hydroquinone cream alone in the treatment of melasma Methods: We selected 40 patients of melasma aged between 18 and 60 years for the study. Group 1 were treated with a cream of 5% hydroquinone and group 2 treated with a solution of hydroquinone 5% plus three sessions of non-ablative fractional 1540 erbium YAG laser at monthly interval. Improvement was assessed by the melasma-area-and-severity-index (MASI) score. Results: The two groups did not differ significantly in (MASI( score in the first month of treatment (p = 0/135), while during the second to fifth months, there were significant differences between the two groups (p <0.05) and (MASI( score was more reduced in the second group. The two groups did not show significant differences in the incidence of complications (erythema, hyperpigmentation, hypopigmentation). (p= 0/746, 0/158, 0/574, 0/135, 0/135 respectively, the first month, second month, third month and fourth month) Conclusion: A combination of hydroquinone and laser therapy had better results in the treatment of melasma. But due to some disagreements about the use of lasers in the treatment of melasma we recommend more studies with larger sample size to be taken to definitely show better therapeutic effect of laser.

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