Iron sucrose /Ferrous-sulfate/folic-acid

2020 ◽  
Vol 1800 (1) ◽  
pp. 183-183
Keyword(s):  
Folic Acid ◽  
Ferrous Sulfate ◽  
Iron Sucrose

scholarly journals Treament and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiânia, Goiás State, Brazil: a randomized controlled trial

2008 ◽  
Vol 24 (suppl 2) ◽  
pp. s259-s271 ◽  
Author(s):  
Maria Claret Costa Monteiro Hadler ◽  
Dirce Maria Sigulem ◽  
Maria de Fátima Costa Alves ◽  
Vinícius Montenegro Torres
Keyword(s):  
Folic Acid ◽  
Ferrous Sulfate ◽  
Controlled Trial ◽  
Acid Group ◽  
Hemoglobin Level ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Treatment Groups ◽  
Daycare Centers ◽  
Randomized Controlled

The objective of this study was to assess the prevalence of anemia and the therapeutic and prophylactic response to ferrous sulfate and folic acid. A double-blind, randomized, controlled clinical trial was conducted with 196 children 6 to 24 months of age enrolled in municipal daycare centers in Goiânia, Goiás State, Brazil. The children were assigned to two treatment groups that received a daily dose (5 times a week) of either 4.2mg/kg/day of ferrous sulfate + folic acid (50µg) or 4.2mg/kg/day of ferrous sulfate + folic acid placebo. One of the prevention groups received 1.4mg/kg/day of ferrous sulfate + folic acid (50µg/day) and the other 1.4mg/kg/day of ferrous sulfate + folic acid placebo. Supplementation lasted approximately three months. Baseline anemia prevalence was 56.1% (95%CI: 48.9-63.1). After treatment, anemia prevalence in the folic acid group (14%) was lower than in the placebo group (34.9%) (p = 0.02). After prophylaxis in the non-anemic children, the incidence of anemia did not differ between the groups, but there was an increase in hemoglobin level in the folic acid group (p = 0.003). Iron plus folic acid was effective for the treatment of anemia and improvement of hemoglobin level in non-anemic children.

scholarly journals Prescribing pattern of nutraceuticals in pediatric outpatient department at tertiary care teaching hospital

2020 ◽  
Vol 9 (7) ◽  
pp. 1060
Author(s):  
Madhuri Kulkarni ◽  
Priyanka Ambekar ◽  
Siddharth Athawale
Keyword(s):  
Folic Acid ◽  
Ferrous Sulfate ◽  
Tertiary Care ◽  
Outpatient Department ◽  
Prescribing Pattern ◽  
Medical College ◽  
Paediatric Outpatient ◽  
Male Patients ◽  
Lifestyle Diseases ◽  
Written Informed Consent

Background: Nutraceuticals use is increasing in a health-conscious society. Because of varying lifestyle diseases, people have changed their outlook towards nutraceuticals. The objective of the study was to study the prescription pattern of nutraceuticals by doctors in paediatric outpatient department of government medical college and hospital, Aurangabad, Maharashtra, India.Methods: This study was done between November 2018 to March 2019. Total of 156 patients were included in the study after obtaining written informed consent from parents of patients. The data was gathered, analysed and results were concluded.Results: Total 156 patients were prescribed nutraceuticals in paediatric outpatient department of which 51.92% female patients and 48.78% male patients received nutraceuticals. In this study, 62% patients received vitamins and 38% patients received vitamins and minerals. 67.31% patient receiving nutraceuticals were above the age of 6 years and 32.69% patients were under the age of 6 years. Among patients receiving nutraceuticals, B complex was received 55.77%. After that calcium lactate + vitamin D tablet were prescribed 21.80%. Ferrous sulfate + folic acid was received by 8.33% patients. Calcium carbonate + vitamin D3 were received by 7.69% patients. Folic acid tablet was received by 5.13% patients and poly-vitamin tablet by 1.28% patients. 100% prescriptions were prescribed in generic names.Conclusions: Nutraceuticals are being increasingly perceived as beneficial to health and are being continuously used in the treatment. The future of nutraceuticals is bright and can transform healthcare in a developing country like India.

scholarly journals Determination of Folic Acid in Multivitamin Preparations by Reversed Phase HPLC

2021 ◽  
Vol 11 (3) ◽  
pp. 185-192
Author(s):  
A. S. Alekseeva ◽  
M. V. Gavrilin ◽  
T. B. Shemeryankina ◽  
M. S. Smirnova ◽  
E. P. Fedorova ◽  
...  
Keyword(s):  
Folic Acid ◽  
Silica Gel ◽  
Ferrous Sulfate ◽  
Reversed Phase ◽  
Asymmetry Factor ◽  
Array Detector ◽  
Isocratic Elution ◽  
Rp Hplc ◽  
Acid Determination

A great variety of components in multivitamin preparations containing folic acid, and a variety of test methods and conditions of folic acid determination proposed by manufacturers, require alignment of test procedures for products with similar composition.The aim of the study was to compare the results of experimental verification of folic acid determination procedures which use reversed phase high-performance liquid chromatography (RP HPLC) with isocratic elution mode. Materials and methods: The Agilent 1260 Infinity II LC system with a diode array detector (280 nm), isocratic elution mode, C8- and C18-bonded silica gel chromatographic columns, model mixtures containing folic acid, cyanocobalamin, ferrous sulfate, and potassium iodide, were used in the study.Results: The lowest relative standard deviation of the folic acid peak area (RSD=0.09%), and the lowest asymmetry factor (As=1.04) for folic acid were observed for the model mixture “ferrous sulfate+folic acid+cyanocobalamin” and the following test conditions. Column: 250×4.0 mm, silica gel for chromatography, octylsilyl (C8), endcapped; mobile phase:  methanol‒phosphate buffer (12:88), pH 6.6; column temperature: 25ºС. The study demonstrated the feasibility of using these conditions for determination of pteroic acid impurity with simultaneous precipitation of interfering ferrous ions, using ethylenediaminetetraacetic acid solution, pH 9.5, as a solvent.Conclusions: RP HPLC can be recommended as an optimal aligned test procedure for determination of folic acid in combination products. It is recommended to use a solution containing folic and pteroic acids for system suitability testing.

scholarly journals Iron Deficiency Anemia in Pregnancy: Intravenous Iron Sucrose versus Oral Iron Sulfate

2020 ◽  
Vol 33 (1) ◽  
pp. 40-44
Author(s):  
Shabera Arzoo ◽  
Shereen Yousof ◽  
Jahanara Rahman ◽  
Sameena Chowdhury
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Ferrous Sulfate ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Deficiency Anemia ◽  
Third Trimester ◽  
Oral Group

Introduction: Injectable iron sucrose and oral ferrous sulfate both are used for the correctionof anaemia in second and third trimester of pregnancy. But injectable iron is supposed to bemore effective than oral iron, as it needs less time for correction of anaemia and efficacy ismore. Oral iron is cost effective but more time consuming.The objective of the study was to compare the safety of intravenous iron sucrose complex inthe treatment of iron deficiency anemia in third trimester of pregnancy. To compare theefficacy of intravenous iron with oral iron. Method: A randomised controlled trial was conducted in which pregnant women with irondeficiency were sequentially selected from the pregnant women attended antenatal clinic ofOPD of Institute of Child and Maternal Health (ICMH) and assigned either to injectable or tooral ferrous sulfate by random number table. Each study patient was given the total calculatedamount of injectable iron sucrose {Hb deficit (gm/l) × body weight (kg) × 0.24+ storage ironmg } in divided dose 200 mg in 200 ml normal saline intravenously over 1 hour everyalternate day . Each patient of the control group was given ferrous sulfate 200mg orally threetimes a day for 4 weeks. Pregnant women follow up at 4 weeks and 8 weeks after gettreatment by oral and injectable iron. During follow up monitored for adverse effects, clinicaland laboratory response and haemoglobin percentage were observed. Result: There were 75 patients in injectable group and 75 patients in oral group. Injectablegroup achieved a significantly higher Hb level (11.49 ± 0.39) than oral group Hb level (10.39± 0.75) after 8 weeks of treatment. Injectable group showed no major side effects, only twopatient had complains .One patient complain of epigastic pain and one patient complain oftachycardia while in oral group complain of nausea and vomiting, epigastic pain, constipation,allergic reaction was found in 42.0%, 39.3%,35.7% and 3.6% respectively. Conclusion: Iron sucrose complex appears to be a safe and effective in the treatment ofiron deficiency anemia. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(1) : 40-44

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