Observation on the Effect of Compound Ferrous Sulfate Folic Acid Tablets in the Treatment of Mild Anemia during Pregnancy

The objective of this study was to assess the prevalence of anemia and the therapeutic and prophylactic response to ferrous sulfate and folic acid. A double-blind, randomized, controlled clinical trial was conducted with 196 children 6 to 24 months of age enrolled in municipal daycare centers in Goiânia, Goiás State, Brazil. The children were assigned to two treatment groups that received a daily dose (5 times a week) of either 4.2mg/kg/day of ferrous sulfate + folic acid (50µg) or 4.2mg/kg/day of ferrous sulfate + folic acid placebo. One of the prevention groups received 1.4mg/kg/day of ferrous sulfate + folic acid (50µg/day) and the other 1.4mg/kg/day of ferrous sulfate + folic acid placebo. Supplementation lasted approximately three months. Baseline anemia prevalence was 56.1% (95%CI: 48.9-63.1). After treatment, anemia prevalence in the folic acid group (14%) was lower than in the placebo group (34.9%) (p = 0.02). After prophylaxis in the non-anemic children, the incidence of anemia did not differ between the groups, but there was an increase in hemoglobin level in the folic acid group (p = 0.003). Iron plus folic acid was effective for the treatment of anemia and improvement of hemoglobin level in non-anemic children.

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Iron-Containing Micronutrient Supplementation of Chinese Women with No or Mild Anemia during Pregnancy Improved Iron Status but Did Not Affect Perinatal Anemia

Journal of Nutrition ◽

10.3945/jn.113.189894 ◽

2014 ◽

Vol 144 (6) ◽

pp. 943-948 ◽

Cited By ~ 10

Author(s):

Zuguo Mei ◽

Mary K. Serdula ◽

Jian-meng Liu ◽

Rafael C. Flores-Ayala ◽

Linlin Wang ◽

...

Keyword(s):

Chinese Women ◽

Iron Status ◽

Micronutrient Supplementation ◽

Mild Anemia ◽

Anemia During Pregnancy

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Prescribing pattern of nutraceuticals in pediatric outpatient department at tertiary care teaching hospital

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20202941 ◽

2020 ◽

Vol 9 (7) ◽

pp. 1060

Author(s):

Madhuri Kulkarni ◽

Priyanka Ambekar ◽

Siddharth Athawale

Keyword(s):

Folic Acid ◽

Ferrous Sulfate ◽

Tertiary Care ◽

Outpatient Department ◽

Prescribing Pattern ◽

Medical College ◽

Paediatric Outpatient ◽

Male Patients ◽

Lifestyle Diseases ◽

Written Informed Consent

Background: Nutraceuticals use is increasing in a health-conscious society. Because of varying lifestyle diseases, people have changed their outlook towards nutraceuticals. The objective of the study was to study the prescription pattern of nutraceuticals by doctors in paediatric outpatient department of government medical college and hospital, Aurangabad, Maharashtra, India.Methods: This study was done between November 2018 to March 2019. Total of 156 patients were included in the study after obtaining written informed consent from parents of patients. The data was gathered, analysed and results were concluded.Results: Total 156 patients were prescribed nutraceuticals in paediatric outpatient department of which 51.92% female patients and 48.78% male patients received nutraceuticals. In this study, 62% patients received vitamins and 38% patients received vitamins and minerals. 67.31% patient receiving nutraceuticals were above the age of 6 years and 32.69% patients were under the age of 6 years. Among patients receiving nutraceuticals, B complex was received 55.77%. After that calcium lactate + vitamin D tablet were prescribed 21.80%. Ferrous sulfate + folic acid was received by 8.33% patients. Calcium carbonate + vitamin D3 were received by 7.69% patients. Folic acid tablet was received by 5.13% patients and poly-vitamin tablet by 1.28% patients. 100% prescriptions were prescribed in generic names.Conclusions: Nutraceuticals are being increasingly perceived as beneficial to health and are being continuously used in the treatment. The future of nutraceuticals is bright and can transform healthcare in a developing country like India.

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Determination of Folic Acid in Multivitamin Preparations by Reversed Phase HPLC

The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products ◽

10.30895/1991-2919-2021-11-2-185-192 ◽

2021 ◽

Vol 11 (3) ◽

pp. 185-192

Author(s):

A. S. Alekseeva ◽

M. V. Gavrilin ◽

T. B. Shemeryankina ◽

M. S. Smirnova ◽

E. P. Fedorova ◽

...

Keyword(s):

Folic Acid ◽

Silica Gel ◽

Ferrous Sulfate ◽

Reversed Phase ◽

Asymmetry Factor ◽

Array Detector ◽

Isocratic Elution ◽

Rp Hplc ◽

Acid Determination

A great variety of components in multivitamin preparations containing folic acid, and a variety of test methods and conditions of folic acid determination proposed by manufacturers, require alignment of test procedures for products with similar composition.The aim of the study was to compare the results of experimental verification of folic acid determination procedures which use reversed phase high-performance liquid chromatography (RP HPLC) with isocratic elution mode. Materials and methods: The Agilent 1260 Infinity II LC system with a diode array detector (280 nm), isocratic elution mode, C8- and C18-bonded silica gel chromatographic columns, model mixtures containing folic acid, cyanocobalamin, ferrous sulfate, and potassium iodide, were used in the study.Results: The lowest relative standard deviation of the folic acid peak area (RSD=0.09%), and the lowest asymmetry factor (As=1.04) for folic acid were observed for the model mixture “ferrous sulfate+folic acid+cyanocobalamin” and the following test conditions. Column: 250×4.0 mm, silica gel for chromatography, octylsilyl (C8), endcapped; mobile phase: methanol‒phosphate buffer (12:88), pH 6.6; column temperature: 25ºС. The study demonstrated the feasibility of using these conditions for determination of pteroic acid impurity with simultaneous precipitation of interfering ferrous ions, using ethylenediaminetetraacetic acid solution, pH 9.5, as a solvent.Conclusions: RP HPLC can be recommended as an optimal aligned test procedure for determination of folic acid in combination products. It is recommended to use a solution containing folic and pteroic acids for system suitability testing.

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Prevalence of anemiain Pregnant women attending a Tertiary level hospital in western Region, Nepal

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v4i2.19086 ◽

2018 ◽

Vol 4 (2) ◽

pp. 17-19

Author(s):

Nabin Rayamajhi ◽

Satyendra Kumar Mishra ◽

Narayan Gautam ◽

Nilesh Raj Doshi

Keyword(s):

Pregnant Women ◽

Hematological Parameters ◽

Cross Sectional Study ◽

Medical Sciences ◽

Cross Sectional ◽

Mild Anemia ◽

Detailed Medical History ◽

High Prevalence ◽

Anemia During Pregnancy ◽

Prevalence Of Anemia

INTRODUCTION: In South Asian Region, the prevalence of anemia among pregnant women has been estimated to be 75% which is highest in the world. Hence, this study was drafted to evaluate the prevalence of anemia in pregnant women in western part of NepalMATERIALS AND METHODS: It was a hospital based cross-sectional study. A total of 200 pregnant ladies aged 15-45 years giving consent for the study were included and their detailed medical history, clinical examination and lab investigations focusing on hematological parameters were documented. Data were entered in excel sheet and analysed by SPSS (17.0).RESULTS: The prevalence of anemia in pregnant women was 48% with increased prevalence as the pregnancy proceeds and reaching its highest during third trimester of pregnancy. Young adults with age ranging from 15-30 years had highest prevalence of anemia. Mild anemia (Hb: 9-10.9 g/dl) was the commonest entity.CONCLUSION: With this high prevalence, screening for anemia during pregnancy should be done. Moreover, exogenous supplementation of iron capsules or diet rich in iron can be advised to those anaemic pregnant women.Journal of Universal College of Medical Sciences (2016)Vol.04 No.02 Issue 14, page: 17-19

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Anemia In Pregnancy With Stunting In Gayam Village District Gurah Kediri

Jurnal Kebidanan Midwiferia ◽

10.21070/midwiferia.v7i1.1319 ◽

2021 ◽

Vol 7 (1) ◽

pp. 81-94

Author(s):

Dewi Taurisiawati Rahayu

Keyword(s):

Sampling Technique ◽

P Value ◽

Test Results ◽

Critical Periods ◽

Mild Anemia ◽

Moderate Anemia ◽

History Of ◽

Anemia During Pregnancy ◽

Independent Variable ◽

The Relationship

The nutritional status and health of the mother during pre-pregnancy, pregnancy, and during breastfeeding was very critical periods for children's growth and development. The aim of this research was to determine the relationship between anemia during pregnancy and the incidence of stunting. The method used in this research was observational correlational analytic, which looking for the relationship between two independent and dependent variables used a cohort-retrospective approach, with the independent variable anemia during pregnancy and the dependent variable the incidence of stunting. The research was conducted from 2 July – 29 August 2020 in Gayam Village, Kediri Distric used MCH book instrument. Total population was 512 toddlers with judgement sampling technique as many as 88 toddlers consisted of 38 stunting and 50 non-stunting toddlers. Analysis used the Spearman Rho with the results of the Spearman value showed that total of 66 toddlers, 4 (6.1%) of stunting toddlers were found with no history of anemia, 13 (19.7%) of stunting toddlers with a history of mild anemia and 5 (7.6%) of stunting toddlers with a history of moderate anemia. Spearman rho test results p value = 0.000. This mean that the p value <α = 0.05, because the p-value <α, H1 accepted, that there was a relationship between a history of anemia during pregnancy and the incidence of stunting on toddlers. Anemia during pregnancy was very risky for the development of fetus and the development of baby that will beb born can caused stunting.

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