scholarly journals Mobilization of Hematopoietic Stem Cells into Peripheral Blood for Autologous Transplantation Seems Less Efficacious in Poor Mobilizers with the Use of a Biosimilar of Filgrastim and Plerixafor: A Retrospective Comparative Analysis

2020 ◽  
Vol 8 (2) ◽  
pp. 311-324
Author(s):  
Rocío Parody ◽  
Isabel Sánchez-Ortega ◽  
Christelle Ferrá ◽  
Ramon Guardia ◽  
Carme Talarn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Comparative Analysis ◽  
Hematopoietic Stem Cells ◽  
Peripheral Blood ◽  
Autologous Transplantation ◽  
Hematopoietic Stem ◽  
Poor Mobilizers

scholarly journals Factors Associated with Successful Mobilization and Collection of Peripheral Blood Hematopoietic Stem Cells in Autologous and Allogeneic Donors

2017 ◽  
Vol 2017 ◽  
pp. 1
Author(s):  
Rada Grubovic ◽  
Borce Georgievski ◽  
Lidija Cevreska ◽  
Sonja Genadieva-Stavric ◽  
Milos R. Grubovic
Keyword(s):  
Stem Cells ◽  
Platelet Count ◽  
Hematopoietic Stem Cells ◽  
Peripheral Blood ◽  
Inverse Correlation ◽  
Hematopoietic Stem ◽  
Laboratory Parameters ◽  
Cd34 Cells ◽  
Number Of Cycles ◽  
Poor Mobilizers

BACKGROUND: Peripheral blood hematopoietic stem cells (PBSC) have largely replaced bone marrow derived stem cells in autologous transplantations, and have become the preferred source of stem cells in the majority of allogeneic transplantations. Sufficient number of mobilized and collected hematopoietic stem cells (HSC) is needed for successful hematopoietic stem cell transplantation.MATERIAL AND METHOD: This study was performed in the Institute for Transfusion Medicine of RM and the University Clinic of Hematology from 2008 till 2016. There were 30 allogeneic and 90 autologous donors that underwent mobilization and collection of PBSC. The association between possible predictive factors such as demographic characteristics, laboratory parameters and collection parameters in both groups, and mobilization strategy and clinical characteristics in autologous donors and number of collected PBSC was analyzed.RESULTS: There were 226 apheresis, 182 in autologous donors (mean 2, range 1-3) and 44 apheresis in 30 allogeneic donors (mean 1.5, range 1-2). The mean number of collected MNC in autologous donors was 3.09 x 108/kg and 2.85 x 106/kg CD34+ cells, and 3.23 x 108/kg MNC and 3.20 x 106/kg CD34+ cells in allogeneic donors. Significantly larger number of MNC and CD34+ cells was collected with the WBC set. There was a statistically significant correlation between the total number of collected MNC in autologous donors and platelet count before mobilization, the number of cycles in one apheresis procedure, quantity of collected graft and the number of collected MNC and CD34+ cells on the first day of harvestration. There was a statistically significant correlation between the total number of collected MNC in allogeneic donors and platelet count before mobilization, the number of cycles in one apheresis procedure, quantity of collected graft and number of MNC on first day of harvestration. There was a strong correlation between the number of collected MNC and CD34+ cells on the first harvest and the total number of collected MNC and CD34+ cells in poor mobilizers, and inverse correlation with the number of apheresis procedures. Donors who donated MNC ≤ 0.7 x 108/kg and/or ≤ 0.7 x 106/kg CD34+ cells on the first harvest (84.6%) were strong predictors of poor mobilizers.CONCLUSION: Determining the proper level of baseline and preaheresis laboratory parameters for initiating mobilization and apheresis procedure which is safe for donors and greatly efficient in collection of PBSC is needed for optimization of these procedures, as well as for early intervention in poor mobilizers.

scholarly journals Bendamustine, etoposide and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in patients with multiple myeloma

2016 ◽  
Vol 51 (10) ◽  
pp. 1330-1336 ◽  
Author(s):  
D J Green ◽  
W I Bensinger ◽  
L A Holmberg ◽  
T Gooley ◽  
B G Till ◽  
...  
Keyword(s):  
Stem Cells ◽  
Multiple Myeloma ◽  
Hematopoietic Stem Cells ◽  
Peripheral Blood ◽  
Autologous Transplantation ◽  
Hematopoietic Stem

scholarly journals Bendamustine, etoposide, and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in non-Hodgkin lymphoma

2018 ◽  
Vol 53 (3) ◽  
pp. 223
Author(s):  
Adam M. Greenbaum ◽  
Damian J. Green ◽  
Leona A. Holmberg ◽  
Ted Gooley ◽  
Brian G. Till ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Hodgkin Lymphoma ◽  
Peripheral Blood ◽  
Autologous Transplantation ◽  
Hematopoietic Stem ◽  
Non Hodgkin Lymphoma

scholarly journals Long-term repopulating hematopoietic stem cells and “side population” in human steady state peripheral blood

2013 ◽  
Vol 11 (1) ◽  
pp. 625-633 ◽  
Author(s):  
Philippe Brunet de la Grange ◽  
Marija Vlaski ◽  
Pascale Duchez ◽  
Jean Chevaleyre ◽  
Veronique Lapostolle ◽  
...  
Keyword(s):  
Stem Cells ◽  
Steady State ◽  
Hematopoietic Stem Cells ◽  
Peripheral Blood ◽  
Side Population ◽  
Hematopoietic Stem

Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells

Blood ◽  
2013 ◽  
Vol 122 (10) ◽  
pp. 1730-1740 ◽  
Author(s):  
Francois Lassailly ◽  
Katie Foster ◽  
Lourdes Lopez-Onieva ◽  
Erin Currie ◽  
Dominique Bonnet
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Comparative Analysis ◽  
Hematopoietic Stem Cells ◽  
Multimodal Imaging ◽  
Intravital Imaging ◽  
Functional Heterogeneity ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Functional Implications

Key Points Comparative analysis of epiphyses, diaphyses, and calvaria in terms of homeostatic HSC content, homing, and early reconstitution is described. Noninvasive intravital imaging of intact bones and assessment of BVF, BRA, and hypoxia are reported.

scholarly journals Evidence of a Pivotal Role for the Distal Part of the Complement Cascade in the Diurnal Release of Hematopoietic Stem Cells into Peripheral Blood

2016 ◽  
Vol 25 (2) ◽  
pp. 275-282 ◽  
Author(s):  
Sylwia Borkowska ◽  
Malwina Suszynska ◽  
Janina Ratajczak ◽  
Mariusz Z. Ratajczak
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Peripheral Blood ◽  
Distal Part ◽  
Pivotal Role ◽  
Complement Cascade ◽  
Hematopoietic Stem

UM171 promotes expansion of autologous peripheral blood hematopoietic stem cells from poorly mobilizing lymphoma patients

2020 ◽  
Vol 81 ◽  
pp. 106266
Author(s):  
Ruiting Wen ◽  
Chen Dong ◽  
Chen Xu ◽  
Long Zhao ◽  
Yang Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Peripheral Blood ◽  
Hematopoietic Stem
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