scholarly journals Pregnancy Loss Signal from Prostaglandin Eye Drop Use in Pregnancy: A Disproportionality Analysis Using Japanese and US Spontaneous Reporting Databases

2021 ◽  
Author(s):  
Takamasa Sakai ◽  
Chiyo Mori ◽  
Honoka Koshiba ◽  
Ryuta Yuminaga ◽  
Kouichi Tanabe ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Spontaneous Reporting ◽  
Disproportionality Analysis ◽  
In Pregnancy

Placental pathology in pregnancy loss

Placenta ◽  
2021 ◽  
Vol 103 ◽  
pp. 256
Author(s):  
Daisuke Fujita ◽  
Misa Nunode ◽  
Masami Sawada ◽  
Yoko Nagayasu ◽  
Takumi Sano ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Placental Pathology ◽  
In Pregnancy

Drug-induced neuropsychiatric adverse events using post-marketing surveillance

2021 ◽  
Vol 16 ◽  
Author(s):  
Tomohito Wakabayashi ◽  
Takahiro Nakatsuji ◽  
Hiroko Kambara ◽  
Iku Niinomi ◽  
Saki Oyama ◽  
...  
Keyword(s):  
Spontaneous Reporting ◽  
Abnormal Behavior ◽  
Drug Event ◽  
Reporting Odds Ratio ◽  
Neuraminidase Inhibitors ◽  
Disproportionality Analysis ◽  
Drug Induced ◽  
Real World Setting ◽  
Post Marketing Surveillance ◽  
Post Marketing

Background: Several studies reported that abnormal behavior was noted in pediatric patients receiving several drugs including neuraminidase inhibitors (NIs). However, information on drugs associated with abnormal behavior in a real-world setting remains limited. The purpose of this study was to clarify drugs associated with abnormal behavior using a spontaneous reporting system database. Methods: We performed a retrospective pharmacovigilance disproportionality analysis using the Japanese Adverse Drug Event Report database. Adverse event reports submitted to the Pharmaceuticals and Medical Devices Agency were analyzed. Drug associated with abnormal behavior were estimated using disproportionality analysis with calculation of the reporting odds ratio and 95% confidence interval. Results: A total of 1,144 reports of abnormal behavior were identified. Signals were detected showing the association of 4 including neuraminidase inhibitors (oseltamivir, zanamivir, laninamivir, and peramivir) with abnormal behavior, and these signals were stronger for oseltamivir than other neuraminidase inhibitors. Signals were also detected for acetaminophen and montelukast. Conclusion: Our results should raise physicians’ awareness of drugs associated with abnormal behavior, but further investigation of these medications is warranted.

Miscarriage After Noninvasive Prenatal Screening—The Value of Genetic Testing in Pregnancy Loss [34J]

2018 ◽  
Vol 131 ◽  
pp. 117S
Author(s):  
Melissa Maisenbacher ◽  
Wendy DiNonno ◽  
Katrina Merrion ◽  
Michael Young ◽  
Styrmir Sigurjonsson ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Pregnancy Loss ◽  
Prenatal Screening ◽  
Noninvasive Prenatal Screening ◽  
In Pregnancy

Stillbirth as the primary manifestation of disseminated tuberculosis in a young immunocompetent mother with multiple perforations of the ileum

2021 ◽  
Vol 14 (2) ◽  
pp. e239386
Author(s):  
Deepak Rajput ◽  
Amit Gupta ◽  
Ravi Roshan ◽  
Arvind Kumar
Keyword(s):  
Weight Loss ◽  
Pregnancy Loss ◽  
Clinical Presentation ◽  
Delayed Presentation ◽  
Female Reproductive System ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
Mother And Child ◽  
In Pregnancy

Tuberculosis (TB), a significant cause of morbidity and mortality worldwide, is particularly relevant in low/middle-income countries like India, where the disease is endemic. The female reproductive system is very vulnerable to this infection with, the clinical presentation being utterly silent in most patients. Symptoms of TB in pregnancy may initially be attributed to the gravidity itself besides temporary concealment of associated weight loss by the normally occurring weight gain during the pregnancy. Untreated TB may cause pregnancy loss by either placental damage or direct harm to both the mother and child. We report a case of latent disseminated TB in a young immunocompetent female that was revealed in the postpartum state (after full-term stillbirth delivery at home) as 20 ileal perforations secondary to intestinal TB. Due to ongoing sepsis and delayed presentation to the hospital, the patient could not be salvaged despite the best possible efforts.

The role of male factor in pregnancy loss

Urologiia ◽  
2021 ◽  
Vol 4_2021 ◽  
pp. 152-157
Author(s):  
M.N. Korshunov Korshunov ◽  
E.S. Korshunova Korshunova ◽  
Yu.V. Kastrikin Kastrikin ◽  
E.A. Efremov Efremov ◽  
S.P. Darenkov Darenkov ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Male Factor ◽  
In Pregnancy

scholarly journals The Role of Glucocorticoids in Pregnancy: Four Decades Experience with Use of Betamethasone in the Prevention of Pregnancy Loss

10.5772/50797 ◽  
2012 ◽  
Author(s):  
Fortunato Vesce ◽  
Emilio Giugliano ◽  
Elisa Cagnazzo ◽  
Stefania Bignardi ◽  
Elena Mossuto ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
In Pregnancy

scholarly journals Pharmacovigilance Assessment of Drug-Induced Acute Pancreatitis Using a Spontaneous Reporting Database

2019 ◽  
Vol 38 (6) ◽  
pp. 487-492 ◽  
Author(s):  
Iku Niinomi ◽  
Keiko Hosohata ◽  
Saki Oyama ◽  
Ayaka Inada ◽  
Tomohito Wakabayashi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Odds Ratio ◽  
Spontaneous Reporting ◽  
Adverse Drug Events ◽  
Drug Event ◽  
Reporting Odds Ratio ◽  
Event Report ◽  
Disproportionality Analysis ◽  
Drug Induced ◽  
Spontaneous Reporting Database

Background: Acute pancreatitis (AP) is associated with risks of morbidity and mortality. The incidence of AP recently increased compared to that traditionally reported in the literature. Objective: The purpose of this study was to evaluate the possible association between AP and drugs using the Japanese Adverse Drug Event Report (JADER) database, which is a spontaneous reporting database of adverse drug events. Methods: Adverse event reports submitted to the JADER database between 2004 and 2017 were analyzed. Disproportionality analysis was performed by calculating the reporting odds ratio (ROR) with 95% confidence intervals for signal detection. Results: A total of 3,443 reports (0.17% of all adverse events) were identified as drug-induced AP, in which 431 different drugs were involved. Acute pancreatitis was frequently reported in men (58.5%) in their 60s (19.1%); 40.6% developed AP within 4 weeks after the treatment. Among the most frequently reported drugs, signals were detected for prednisolone, ribavirin, sitagliptin, mesalazine, tacrolimus, and l-asparaginase, which are well-known causes of AP. Telaprevir, donepezil, and ustekinumab also generated signals. As for drugs with high RORs, l-asparaginase and alogliptin were noteworthy. Conclusion: Most of the identified drugs were already known to induce AP, but the likelihood of the reporting of AP varied among the drugs. Our results should raise physicians’ awareness of drugs associated with AP, but further investigation of these medications is warranted.

In vitro-produced horse embryos exhibit a very narrow window of acceptable recipient mare uterine synchrony compared with in vivo-derived embryos

2019 ◽  
Vol 31 (12) ◽  
pp. 1904 ◽  
Author(s):  
Juan Cuervo-Arango ◽  
Anthony N. Claes ◽  
Tom A. E. Stout
Keyword(s):  
Pregnancy Rate ◽  
Pregnancy Loss ◽  
Oestrous Cycle ◽  
Ongoing Pregnancy ◽  
Ongoing Pregnancy Rate ◽  
Wide Range ◽  
In Pregnancy

In recent years, the number of equine invitro-produced embryos (IVP) has increased markedly; as yet, there are few reports on what constitutes an ‘ideal’ recipient for an IVP embryo. This study retrospectively investigated the effects of recipient mare oestrous cycle characteristics on the likelihood of pregnancy after transfer of IVP (n=264) and invivo-derived embryos (n=262). IVP embryos tolerated only a narrow window of recipient mare ‘synchrony’, with transfer on Day 4 after ovulation resulting in a higher likelihood of ongoing pregnancy (69%) than transfer on Days 3, 5 or 6 (53.2%, 41.3% and 23.1% respectively; P=0.02). In contrast, Day 8 invivo-derived embryos tolerated a wide range of uterine (a)synchrony, with no difference in pregnancy or pregnancy loss for recipients that ovulated between Day 4 and Day 9 before transfer. However, transferring invivo-derived embryos to recipients that had a longer oestrus preceding transfer resulted in higher Day 12 and ongoing pregnancy rate (P<0.01). This effect was not significant in IVP embryos. In conclusion, Day 6–8 IVP blastocysts survive best after transfer to Day 4 recipient mares; Day 8 invivo-derived embryos survive equally well in Day 4–9 recipients, but do better in mares that have a long preceding oestrus.

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