Potential for Stem Cell-Based Therapy in the Road of Treatment for Neurological Disorders Secondary to COVID-19

: Several human neurological disorders such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis; Huntington’s disease, spinal cord injury, multiple sclerosis, and brain stroke, are caused by the injury to neurons or glial cells. The recent years have witnessed the successful generation of neurons and glia cells driving efforts to develop stem-cell-based therapies for patients to combat a broad spectrum of human neurological diseases. The inadequacy of suitable cell types for cell replacement therapy in patients suffering from neurological disorders have hampered the development of this promising therapeutic approach. Attempts are thus being made to reconstruct viable neurons and glial cells from different stem cells such as the embryonic stem cells, mesenchymal stem cells, and neural stem cells. Dedicated research to cultivate stem cell-based brain transplantation therapies have been carried out. We aim at compiling the breakthroughs in the field of stem cell-based therapy for the treatment of neurodegenerative maladies, emphasizing on the shortcomings faced, victories achieved, and the future prospects of the therapy in clinical settings.

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Stem cell therapy for neurological disorders

Translational Neuroscience ◽

10.2478/s13380-011-0040-3 ◽

2011 ◽

Vol 2 (4) ◽

Author(s):

Koraljka Baronica ◽

Latica Friedrich

Keyword(s):

Stem Cells ◽

Stem Cell ◽

Neurological Disorders ◽

Neuronal Damage ◽

Treatment Options ◽

Therapeutic Benefit ◽

Functional Restoration ◽

Efficient Treatment ◽

Cell Based Therapy ◽

The Central Nervous System

AbstractStem cells have long been in focus as potential therapy or even cure for a whole myriad of diseases. Many neurodegenerative disorders, both acute and chronic, are characterized by irreversible neuronal damage and loss, and only a few efficient treatment options exist. In contrast to many other tissues, the potential of self-regeneration of the central nervous system is highly limited. There is hope that stem cells could replace the damaged neuronal and glial cells, and provide biological and functional restoration based on their properties of self renewal and the ability to give rise to different cells. In recent years, the promising results of research on animal models has led to the establishment of the first clinical trials; although no clear evidence of therapeutic benefit for any of the conditions have been ascertained. Here we give a review of the current strategies of stem-cell based therapy for some of the more common neurological disorders, discussing the progress and current challenges, and giving an overview of future perspectives.

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STEM CELLS THERAPY IN HUMAN WELFARE AND DISEASE

Era s journal of medical research ◽

10.24041/ejmr2020.39 ◽

2020 ◽

Vol 7 (2) ◽

pp. 229-234

Author(s):

Ravi Prakash ◽

Santosh Kumar Yadav ◽

Syed Shadab Raza

Keyword(s):

Stem Cells ◽

Stem Cell ◽

Neurological Disorders ◽

Therapeutic Potential ◽

Neurological Diseases ◽

The Body ◽

Human Welfare ◽

Developmental Issues ◽

Cell Based Therapy ◽

Stem Cells Therapy

The study Global Burden of Disease (GBD) drew international healthcare community's attention to the burden of neurological disorders and many other chronic conditions. This study highlighted that the burden of neurological disorders was seriously underrated by traditional epidemiological and health statistical methods that prefer only mortality rates but not disability rates. There has recently been a great deal of interest in stem cells and the nervous system, in terms of their potential for deciphering developmental issues as well as their therapeutic potential. With the advancement in cell culture, isolation techniques, and molecular analyses, various types of stem cells have now been broadly classified, isolated, and characterized from different parts of the body, even from brain and heart. The concept of stem cell-based therapy provided new hope for the treatment of neurological diseases. In this review we will discuss about ongoing stem cell therapy for neurodegenerative disease.

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Bioluminescence, MRI, and PET Imaging Modalities of Stem Cell–Based Therapy for Neurological Disorders

Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging ◽

10.1201/b11182-24 ◽

2011 ◽

pp. 376-391

Keyword(s):

Stem Cell ◽

Pet Imaging ◽

Neurological Disorders ◽

Imaging Modalities ◽

Cell Based Therapy

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Gene-modified Mesenchymal Stem Cell–based Therapy in Renal Ischemia- Reperfusion Injury

Current Gene Therapy ◽

10.2174/1566523218666180214094253 ◽

2018 ◽

Vol 17 (6) ◽

pp. 453-460 ◽

Cited By ~ 2

Author(s):

Hongbo Xu ◽

Cheng Chen ◽

Linkun Hu ◽

Jianquan Hou

Keyword(s):

Stem Cell ◽

Mesenchymal Stem Cell ◽

Reperfusion Injury ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Renal Ischemia ◽

Cell Based Therapy ◽

Renal Ischemia Reperfusion Injury

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Addressing the importance of Stem cell-based therapy: a Perspective in the treatment of COVID-19’

Current Molecular Medicine ◽

10.2174/1566524020999201117120147 ◽

2020 ◽

Vol 20 ◽

Author(s):

Christine Ibrahim ◽

Hanna Semaan ◽

Marwan El-Sabban ◽

Fadia Najjar ◽

Aline Hamade

Keyword(s):

Stem Cell ◽

Drug Repositioning ◽

World Health ◽

Unknown Etiology ◽

Cell Based Therapy ◽

Pathogenic Virus ◽

Lung Injuries ◽

Healthcare Crisis ◽

Health Organization ◽

Potential Use

: Severe acute respiratory syndrome-associated corona virus 2 (SARS-CoV-2), is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO) pointing to the over 118000 cases of Coronavirus disease 2019 (COVID- 19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview on the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.

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