Structural diversity and biological activity of natural p-terphenyls

2021 ◽  
Author(s):  
Guoliang Zhou ◽  
Tianjiao Zhu ◽  
Qian Che ◽  
Guojian Zhang ◽  
Dehai Li
Keyword(s):  
Biological Activity ◽  
Structural Diversity

Bisabolane-type sesquiterpenoids: Structural diversity and biological activity

2021 ◽  
Vol 192 ◽  
pp. 112927
Author(s):  
Hong-Zhen Shu ◽  
Cheng Peng ◽  
Lan Bu ◽  
Li Guo ◽  
Fei Liu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Structural Diversity

scholarly journals Terpenoids from Marine Soft Coral of the Genus Xenia in 1977 to 2019

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5386
Author(s):  
Shean-Yeaw Ng ◽  
Chin-Soon Phan ◽  
Takahiro Ishii ◽  
Takashi Kamada ◽  
Toshiyuki Hamada ◽  
...  
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
South China Sea ◽  
South China ◽  
Coastal Waters ◽  
Soft Coral ◽  
Structural Diversity ◽  
Chemical Diversity ◽  
Comprehensive Overview ◽  
Coral Genus

Members of the marine soft coral genus Xenia are rich in a diversity of diterpenes. A total of 199 terpenes consisting of 14 sesquiterpenes, 180 diterpenes, and 5 steroids have been reported to date. Xenicane diterpenes were reported to be the most common chemical skeleton biosynthesized by members of this genus. Most of the literature reported the chemical diversity of Xenia collected from the coral reefs in the South China Sea and the coastal waters of Taiwan. Although there was a brief review on the terpenoids of Xenia in 2015, the present review is a comprehensive overview of the structural diversity of secondary metabolites isolated from soft coral genus Xenia and their potent biological activity as reported between 1977 to 2019.

Recent progress in andrographolide derivatization: structural modification and biological activity

2021 ◽  
Vol 21 ◽  
Author(s):  
Wang Wang ◽  
Yueying Yang ◽  
Yang Liu ◽  
Dejuan Sun ◽  
Hua Li ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Modification ◽  
Structural Modification ◽  
Recent Progress ◽  
Biological Activities ◽  
Structural Diversity ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Novel Drugs ◽  
Labdane Diterpenoid

: Natural products have remarkable structural diversity and biological characteristics, providing researchers with more possibilities to develop novel drugs for disease therapeutics. Andrographolide, an ent-labdane diterpenoid from traditional Chinese medicines, Andrographis paniculata, exhibits a broad range of biological activities, which has been a hot area of research for several years. Up to now, lots of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes andrographolide derivatives prepared in the last ten years (2006-present), classifies them by different biological activities, and provides some discussion about the design of novel and potent derivatives.

Structural diversity and bioactivities of natural benzophenones

2014 ◽  
Vol 31 (9) ◽  
pp. 1158-1174 ◽  
Author(s):  
Shi-Biao Wu ◽  
Chunlin Long ◽  
Edward J. Kennelly
Keyword(s):  
Biological Activity ◽  
Structural Diversity

Natural benzophenones are a class of compounds with more than 300 members, mainly in the Clusiaceae family. We review key benzophenones, and provide an in-depth discussion of their great structural diversity and biological activity.

Structural Diversity and Biological Activity of the GenusPierisTerpenoids

2017 ◽  
Vol 65 (46) ◽  
pp. 9934-9949 ◽  
Author(s):  
Chun-Huan Li ◽  
Xi-Tao Yan ◽  
An-Ling Zhang ◽  
Jin-Ming Gao
Keyword(s):  
Biological Activity ◽  
Structural Diversity

Relationships between Molecular Complexity, Biological Activity, and Structural Diversity

2006 ◽  
Vol 46 (2) ◽  
pp. 525-535 ◽  
Author(s):  
Ansgar Schuffenhauer ◽  
Nathan Brown ◽  
Paul Selzer ◽  
Peter Ertl ◽  
Edgar Jacoby
Keyword(s):  
Biological Activity ◽  
Structural Diversity ◽  
Molecular Complexity

scholarly journals 6’-Amino-5,7-Dibromo-2-Oxo-3’-(Trifluoromethyl)-1’H-Spiro[Indoline-3,4’-Pyrano[2,3-c]Pyrazole]-5’-Carbonitrile

Molbank ◽  
10.3390/m1309 ◽  
2021 ◽  
Vol 2022 (1) ◽  
pp. M1309
Author(s):  
Yuliya E. Ryzhkova ◽  
Varvara M. Kalashnikova ◽  
Michail N. Elinson
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Biological Activity ◽  
Infrared Spectroscopy ◽  
Sodium Acetate ◽  
Multicomponent Reactions ◽  
Structural Diversity ◽  
Synthetic Methods ◽  
Environmentally Benign ◽  
Complex Molecules ◽  
Synthetic Target

The multicomponent reactions are environmentally benign synthetic methods of building-up of complex molecules and several levels of structural diversity for diverse applications. Spirooxindoles are an important synthetic target possessing extended biological activity and drug discovery applications. In this communication, the multicomponent transformation of 5,7-dibromoisatin, malononitrile, and 5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in EtOH at reflux in the presence of sodium acetate was carefully investigated to give 6’-amino-5,7-dibromo-2-oxo-3’-(trifluoromethyl)-1’H-spiro[indoline-3,4’-pyrano[2,3-c]pyrazole]-5’-carbonitrile in excellent yield. The structure of the new compound was established by means of elemental analysis, mass and nuclear magnetic resonance, and infrared spectroscopy.

scholarly journals Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.

2019 ◽  
Vol 15 ◽  
pp. 2003-2012 ◽  
Author(s):  
Annika Stein ◽  
Dave Compera ◽  
Bianka Karge ◽  
Mark Brönstrup ◽  
Jakob Franke
Keyword(s):  
Biological Activity ◽  
Sex Hormones ◽  
Chemical Reactions ◽  
Structural Diversity ◽  
Physalis Peruviana ◽  
Antiproliferative Activities

Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity. Here, we report two newly characterised withanolides, named irinans, from Physalis peruviana with highly unusual truncated backbones that resemble mammalian androstane sex hormones. Based on biomimetic chemical reactions, we propose a model that links these compounds to withanolide biosynthesis. Irinans have potent antiproliferative activities, that are however lower than those of 4ß-hydroxywithanolide E. Our work establishes androwithanolides as a new subclass of withanolides.

scholarly journals Identification and Heterologous Expression of the Albucidin Gene Cluster from the Marine Strain Streptomyces Albus Subsp. Chlorinus NRRL B-24108

2020 ◽  
Vol 8 (2) ◽  
pp. 237 ◽  
Author(s):  
Maksym Myronovskyi ◽  
Birgit Rosenkränzer ◽  
Marc Stierhof ◽  
Lutz Petzke ◽  
Tobias Seiser ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterologous Expression ◽  
Gene Cluster ◽  
Gene Annotation ◽  
Structural Diversity ◽  
Minimal Set ◽  
Streptomyces Albus ◽  
Marine Strain ◽  
Promising Source ◽  
Producer Strains

Herbicides with new modes of action and safer toxicological and environmental profiles are needed to manage the evolution of weeds that are resistant to commercial herbicides. The unparalleled structural diversity of natural products makes these compounds a promising source for new herbicides. In 2009, a novel nucleoside phytotoxin, albucidin, with broad activity against grass and broadleaf weeds was isolated from a strain of Streptomyces albus subsp. chlorinus NRRL B-24108. Here, we report the identification and heterologous expression of the previously uncharacterized albucidin gene cluster. Through a series of gene inactivation experiments, a minimal set of albucidin biosynthetic genes was determined. Based on gene annotation and sequence homology, a model for albucidin biosynthesis was suggested. The presented results enable the construction of producer strains for a sustainable supply of albucidin for biological activity studies.

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