scholarly journals COMPUTERIZED MEIOTIC MAPPING IN ASPERGILLUS NIDULANS

Genetics ◽  
1972 ◽  
Vol 72 (4) ◽  
pp. 595-605
Author(s):  
Gordon L Dorn
Keyword(s):  
Genetic Analysis ◽  
Aspergillus Nidulans ◽  
Computer System ◽  
Computer Analysis ◽  
Gene Sequences ◽  
Gene Group ◽  
Advantages And Disadvantages ◽  
Meiotic Mapping ◽  
Coefficient Of Coincidence

ABSTRACT A computer system for the storage and processing of microbial meiotic data has been developed. Based on the language Fortran 4, the program retrieves relevant data and determines the order, map distances, and coefficient of coincidence for any three-gene group. Meiotic data from Aspergillus nidulans were used to test the program. A total of 61 three-gene sequences were processed, and the results were found to be compatible with the published values. The advantages and disadvantages of computer analysis for genetic analysis are discussed.

A high-resolution meiotic mapping panel for the pericentromeric region of chromosome 10

Genomics ◽  
1992 ◽  
Vol 13 (3) ◽  
pp. 607-612 ◽  
Author(s):  
Jay B. Lichter ◽  
Jingshi Wu ◽  
Diane Miller ◽  
Paul J. Goodfellow ◽  
Kenneth K. Kidd
Keyword(s):  
High Resolution ◽  
Pericentromeric Region ◽  
Chromosome 10 ◽  
Mapping Panel ◽  
Meiotic Mapping

Localization of the OTF3 Gene within the Human MHC Class I Region by Physical and Meiotic Mapping

Genomics ◽  
1994 ◽  
Vol 21 (1) ◽  
pp. 241-243 ◽  
Author(s):  
Brigitte Crouau-Roy ◽  
Claire Amadou ◽  
Cathy Bouissou ◽  
John Clayton ◽  
Corine Vernet ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Meiotic Mapping ◽  
Class I Region

Meiotic mapping of murine chromosome 17: The string of loci around l(17)-2Pas

1991 ◽  
Vol 1 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Thomas R. King ◽  
William F. Dove ◽  
Jean-Louis Gu�net ◽  
Bernhard G. Herrmann ◽  
Alexandra Shedlovsky
Keyword(s):  
Chromosome 17 ◽  
Murine Chromosome ◽  
Meiotic Mapping

scholarly journals Happy mapping as an alternative to overcome the problems in coconut genome mapping

CORD ◽  
2004 ◽  
Vol 20 (02) ◽  
pp. 34
Author(s):  
C.K. Bandaranayake
Keyword(s):  
Quantitative Trait Loci ◽  
Physical Mapping ◽  
Quantitative Trait ◽  
Marker Assisted Selection ◽  
Genome Mapping ◽  
Mapping Population ◽  
Mapping Method ◽  
Trait Loci ◽  
Meiotic Mapping

An excellent way of producing a reliable mapping population for quantitative trait loci analysis and marker assisted selection was considered. A physical mapping method known as ‘Happy Mapping’ was discussed to make a framework map as an alternative to overcome the problems associated with meiotic mapping.

scholarly journals De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

2021 ◽  
Author(s):  
Anne-Perrine Foray ◽  
Sophie Candon ◽  
Sara Hildebrand ◽  
Cindy Marquet ◽  
Fabrice Valette ◽  
...  
Keyword(s):  
De Novo ◽  
Autoimmune Diabetes ◽  
Nod Mice ◽  
Dual Specificity Phosphatase ◽  
Dual Specificity ◽  
Significant Difference ◽  
Causative Effect ◽  
Meiotic Mapping ◽  
High Level

AbstractHere we report the isolation by selective breeding of two sublines of Non-Obese Diabetic (NOD) mice exhibiting a significant difference in the incidence of autoimmune type 1 diabetes (T1D). Whole genome sequencing of the NOD/NckH (high T1D incidence) and NOD/NckL (low T1D incidence) revealed the presence of a limited number of variants specific to each subline. Treating the age of T1D onset as a quantitative trait and using automated meiotic mapping (AMM), enhanced susceptibility in the NOD/NckH subline was unambiguously attributed to a recessive allele of Dusp10 which encodes a dual specificity phosphatase. The causative effect of the mutation was verified with a high level of confidence by targeting Dusp10 with CRISPR/Cas9 in NOD/NckL mice: in these animals a higher incidence of diabetes was observed. Expression of wild-type Dusp10 correlated with higher levels of surface PD-L1 in the islets of NOD/NckL mice.

scholarly journals Physical and Meiotic Mapping of the Region of Human Chromosome 4q11–q13 Encompassing the Vitamin D Binding Protein DBP/Gc-Globulin and Albumin Multigene Cluster

1999 ◽  
Vol 9 (6) ◽  
pp. 581-587
Author(s):  
Young-Han Song ◽  
Anna K. Naumova ◽  
Stephen A. Liebhaber ◽  
Nancy E. Cooke
Keyword(s):  
Vitamin D ◽  
Transcriptional Regulation ◽  
Human Chromosome ◽  
Physical Map ◽  
Binding Protein ◽  
Regulatory Elements ◽  
Vitamin D Binding Protein ◽  
Functional Studies ◽  
Meiotic Mapping

The vitamin D binding protein/Gc-globulin (DBP) gene is a member of a multigene cluster that includes albumin (ALB), α-fetoprotein (AFP), and α-albumin/afamin (AFM). All four genes have structural and functional similarities and map to the same chromosomal regions in humans (4q11–q13), mice, and rats. An accurate physical map of the region encompassing these genes is a prerequisite for study of their respective transcriptional regulation and identification of potential shared regulatory elements. By refining the physical and meiotic maps of the 4q11–q13 region and creating a local PAC contig, the order and transcriptional orientations of these four genes were determined to be centromere–3′-DBP-5′–5′-ALB-3′–5′-AFP-3′–5′-AFM3′–telomere. The ancestral DBP gene was separated from the ALBgene by >1.5 Mb. This organization and spacing establishes a foundation for ongoing functional studies in this region.

scholarly journals Chromosomal Translocation and Segmental Duplication in Cryptococcus neoformans

2005 ◽  
Vol 4 (2) ◽  
pp. 401-406 ◽  
Author(s):  
James A. Fraser ◽  
Johnny C. Huang ◽  
Read Pukkila-Worley ◽  
J. Andrew Alspaugh ◽  
Thomas G. Mitchell ◽  
...  
Keyword(s):  
Cryptococcus Neoformans ◽  
Segmental Duplication ◽  
Chromosomal Translocation ◽  
Genome Project ◽  
Fungal Genome ◽  
Segmental Duplications ◽  
Physical Evidence ◽  
A Genome ◽  
Strain Pair ◽  
Meiotic Mapping

ABSTRACT Large chromosomal events such as translocations and segmental duplications enable rapid adaptation to new environments. Here we marshal genomic, genetic, meiotic mapping, and physical evidence to demonstrate that a chromosomal translocation and segmental duplication occurred during construction of a congenic strain pair in the fungal human pathogen Cryptococcus neoformans. Two chromosomes underwent telomere-telomere fusion, generating a dicentric chromosome that broke to produce a chromosomal translocation, forming two novel chromosomes sharing a large segmental duplication. The duplication spans 62,872 identical nucleotides and generated a second copy of 22 predicted genes, and we hypothesize that this event may have occurred during meiosis. Gene disruption studies of one embedded gene (SMG1) corroborate that this region is duplicated in an otherwise haploid genome. These findings resolve a genome project assembly anomaly and illustrate an example of rapid genome evolution in a fungal genome rich in repetitive elements.

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