Objective: To investigate the perioperative treatment of patients with breast cancer complicated with rheumatic heart disease. Methods: The perioperative treatment of rheumatic heart disease in 2400 patients with breast cancer treated in our hospital from January 2007 to August 2011 were retrospectively analyzed. Results: Two of the 2400 patients with breast cancer had rheumatic heart disease, aged 71 and 55 years, respectively. One case with atrial fibrillation, and the other one case of mitral valve replacement valve, were treated with warfarin anticoagulant therapy. Two patients in the first 5 days before the withdrawal of warfarin, while low molecular weight heparin or fondaparinux sodium anticoagulant therapy, intraoperative careful hemostasis, as appropriate after the start of anticoagulant therapy. Patients within 24 hours after the incision area of ecchymosis, to adjust the anticoagulant drugs, to strengthen the drainage and hemostasis and other measures improved. Conclusion: Patients with breast cancer complicated with rheumatic heart disease are more complicated due to basic diseases, and their perioperative treatment is more complicated. Excessive anticoagulation or hemostatic treatment will lead to adverse reactions. Perioperative attention should be paid to monitor and adjust the patient INR value, intraoperative need to carefully hemostasis, as far as possible to stop bleeding, reduce coagulation, close observation of patients with local wound conditions, strengthen drainage, if necessary, add hemostatic, and more can be better The treatment effect.
Hypermethylation of brain natriuretic peptide gene is associated with the risk of rheumatic heart disease
