A microviscosity barrier in the lipid bilayer due to the presence of phospholipids containing unsaturated acyl chains

1978 ◽  
Vol 81 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Keith R. Thulborn ◽  
F. Edward Treloar ◽  
William H. Sawyer
Keyword(s):  
Lipid Bilayer ◽  
Unsaturated Acyl ◽  
Acyl Chains

Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide

2015 ◽  
Vol 51 (78) ◽  
pp. 14656-14659 ◽  
Author(s):  
J.-M. Swiecicki ◽  
M. Di Pisa ◽  
F. Lippi ◽  
S. Chwetzoff ◽  
C. Mansuy ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Acyl Chain ◽  
Unsaturated Acyl ◽  
Acyl Chains

Unsaturated acyl chain favours direct translocation of short cationic NBD-labelled peptide.

Interaction between lipid bilayers and a new class of antineoplastic agents derived from arylchloroethylurea: a 2H solid-state NMR study

1998 ◽  
Vol 76 (2-3) ◽  
pp. 465-471 ◽  
Author(s):  
Audrey Saint-Laurent ◽  
Nadine Boudreau ◽  
René C.-Gaudreault ◽  
Patrick Poyet ◽  
Michèle Auger
Keyword(s):  
Lipid Bilayer ◽  
Lipid Bilayers ◽  
Antineoplastic Agents ◽  
Acyl Chain ◽  
Resonance Spectroscopy ◽  
Interfacial Region ◽  
Molar Ratios ◽  
New Class ◽  
Nmr Study ◽  
Acyl Chains

We have investigated the interaction between a new class of antineoplastic agents derived from arylchloroethylurea (CEU) and model membrane of dimyristoylphosphatidylcholine by deuterium nuclear magnetic resonance spectroscopy. The results indicate that the drug incorporates in the bilayer and causes an increase of the lipid acyl chain order, this effect being greater close to the interfacial region of the lipid bilayer. The increase in ordering is dependent on the nature (degree of ramification, length of the alkyl chain, and presence of a sulfur atom) as well as on the position of the R substituent and is correlated with the cytotoxicity of the drugs. More specifically, the more cytotoxic drugs, such as 4-sec-butyl CEU, are those having a bulky ramified substituent and those for which the ordering effect on the lipid bilayer is the smallest. On the other hand, the ordering effect is greater and seen all along the lipid acyl chains for the long-chain CEUs, such as n-hexadecyl CEU, which have been shown to have very weak cytotoxic activity. Finally, the results obtained as a function of the drug concentration indicate that the ordering effect is seen for lipid to drug molar ratios as low as 20:1.Key words: deuterium, NMR, membrane, arylchloroethylurea, liposome.

scholarly journals Gramicidin channels in phospholipid bilayers with unsaturated acyl chains

1997 ◽  
Vol 73 (3) ◽  
pp. 1310-1319 ◽  
Author(s):  
J. Girshman ◽  
D.V. Greathouse ◽  
R.E. Koeppe ◽  
O.S. Andersen
Keyword(s):  
Phospholipid Bilayers ◽  
Unsaturated Acyl ◽  
Acyl Chains

Neutral Lipids Rigidify Unsaturated Acyl Chains in Senescing Membranes

1983 ◽  
Vol 34 (3) ◽  
pp. 268-276 ◽  
Author(s):  
R. F. BARBER ◽  
J. E. THOMPSON
Keyword(s):  
Neutral Lipids ◽  
Unsaturated Acyl ◽  
Acyl Chains

Anti-tumor-promoting activity of simple models of galactoglycerolipids with branched and unsaturated acyl chains

2005 ◽  
Vol 40 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Diego Colombo ◽  
Laura Franchini ◽  
Lucio Toma ◽  
Fiamma Ronchetti ◽  
Nami Nakabe ◽  
...  
Keyword(s):  
Unsaturated Acyl ◽  
Acyl Chains ◽  
Simple Models
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