Anti-tumor-promoting activity of simple models of galactoglycerolipids with branched and unsaturated acyl chains

2005 ◽  
Vol 40 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Diego Colombo ◽  
Laura Franchini ◽  
Lucio Toma ◽  
Fiamma Ronchetti ◽  
Nami Nakabe ◽  
...  
Keyword(s):  
Unsaturated Acyl ◽  
Acyl Chains ◽  
Simple Models

Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide

2015 ◽  
Vol 51 (78) ◽  
pp. 14656-14659 ◽  
Author(s):  
J.-M. Swiecicki ◽  
M. Di Pisa ◽  
F. Lippi ◽  
S. Chwetzoff ◽  
C. Mansuy ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Acyl Chain ◽  
Unsaturated Acyl ◽  
Acyl Chains

Unsaturated acyl chain favours direct translocation of short cationic NBD-labelled peptide.

scholarly journals Gramicidin channels in phospholipid bilayers with unsaturated acyl chains

1997 ◽  
Vol 73 (3) ◽  
pp. 1310-1319 ◽  
Author(s):  
J. Girshman ◽  
D.V. Greathouse ◽  
R.E. Koeppe ◽  
O.S. Andersen
Keyword(s):  
Phospholipid Bilayers ◽  
Unsaturated Acyl ◽  
Acyl Chains

Neutral Lipids Rigidify Unsaturated Acyl Chains in Senescing Membranes

1983 ◽  
Vol 34 (3) ◽  
pp. 268-276 ◽  
Author(s):  
R. F. BARBER ◽  
J. E. THOMPSON
Keyword(s):  
Neutral Lipids ◽  
Unsaturated Acyl ◽  
Acyl Chains

Modulation of tubular microstructural self-assembly in galactosylceramides: Influence of N-linked fatty acyl chains

1996 ◽  
Vol 54 ◽  
pp. 936-937
Author(s):  
Vitthal S. Kulkarni ◽  
Rhoderick E. Brown
Keyword(s):  
Self Assembly ◽  
Room Temperature ◽  
Structural Parameters ◽  
Freeze Fracture ◽  
Fatty Acyl ◽  
Bovine Brain ◽  
Tubule Formation ◽  
Aqueous Dispersions ◽  
Unsaturated Acyl ◽  
Acyl Chains

Our recent studies have indicated that aqueous dispersions of galactosylceramides (GalCers) containing nervonoyl [24:1Δ15(CiS)] acyl chains, which constitute the major unsaturated acyl moieties in bovine brain GalCer, form tubular bilayers. In an effort to define the structural parameters that modulate tubule formation, we synthesized a series.of GalCers having successively shorter cis monounsaturated acyl chains than the tubule-forming 24:1 GalCer and investigated the resulting microstructural self-assemblies by freeze fracture and deep etch electron microscopy.GalCers having W-linked erucic [22:1Δ13(CiS)], eicosenoic [20:Δ11(CiS)], or oleic [18:Δ9(CiS)] acyl chains were synthesized and purified as previously reported for 24:1 GalCer. Dispersions were prepared by hydrating dry lipid at >90°C with phosphate buffer (pH 6.6) followed by vigorous vortexing and three freeze-thaw cycles. Samples were cryo-fixed from room temperature (22°C) by plunging into liquid propane cooled by liquid nitrogen, were fractured in a Balzers 300 freeze fracture apparatus at -120°C, and were etched for 6 min. at -100°C.

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