Recombinant DNA-derived methionyl human growth hormone is similar in membrane binding properties to human pituitary growth hormone

1982 ◽  
Vol 106 (1) ◽  
pp. 202-209 ◽  
Author(s):  
Ron G. Rosenfeld ◽  
Bharat B. Aggarwal ◽  
Raymond L. Hintz ◽  
Laura A. Dollar
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Recombinant Dna ◽  
Membrane Binding ◽  
Human Growth ◽  
Binding Properties ◽  
Human Pituitary ◽  
Pituitary Growth Hormone

Comparison of methionyl human growth hormone and pituitary growth hormone on somatic growth of hypophysectomized rats

1984 ◽  
Vol 107 (2) ◽  
pp. 192-198 ◽  
Author(s):  
A. Skottner ◽  
A. Forsman ◽  
E. Löfberg ◽  
K.-G. Thorngren
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Bone Growth ◽  
Biological Effects ◽  
Human Growth ◽  
Male Rats ◽  
Cartilage Growth ◽  
Human Pituitary ◽  
Longitudinal Bone Growth ◽  
Pituitary Growth Hormone

Abstract. In hypophysectomized male rats the biological effects of two batches of methionyl human growth hormone, Somatonorm®, (met-hGH), have been compared to those of human pituitary growth hormone, Crescormon® (hGH). The rats were treated with doses ranging from 10 mIU per day to 145 mIU per day for 10 days. The parameters studied were total weight gain, longitudinal bone growth, measured by the tetracycline method and indirect cartilage growth, measured by uptake of radioactive sulphate. The results obtained demonstrated that Somatonorm® stimulated weight increase in a linear and dose-dependent way, similar to that seen with the native hormone. Longitudinal bone growth, measured by the tetracycline method and the growth of different cartilages, measured as uptake of radioactive sulphate, were also similar between the two hormones.

Binding properties and structural changes of human growth hormone upon interaction with cobalt ion

2006 ◽  
Vol 89 (3) ◽  
pp. 921-927 ◽  
Author(s):  
A. A. Saboury ◽  
H. Ghourchaei ◽  
M. H. Sanati ◽  
M. S. Atri ◽  
M. Rezaei-Tawirani ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Structural Changes ◽  
Human Growth ◽  
Binding Properties ◽  
Cobalt Ion

Hyperglycemic Activity in Dogs of Recombinant DNA-Derived 20,000 Dalton Variant of Methionyl Human Growth Hormone

1986 ◽  
Vol 12 (1) ◽  
pp. 21-35 ◽  
Author(s):  
C. J. Shaar ◽  
E. L. Grinnan ◽  
W. G. Short ◽  
J. G. Powell ◽  
N. Bryan ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Recombinant Dna ◽  
Human Growth
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