Both Human Pituitary Growth Hormone and Recombinant DNA-Derived Human Growth Hormone Cause Insulin Resistance at a Postreceptor Site*

1982 ◽  
Vol 54 (5) ◽  
pp. 1033-1038 ◽  
Author(s):  
RON G. ROSENFELD ◽  
DARRELL M. WILSON ◽  
LAURA A. DOLLAR ◽  
ANN BENNETT ◽  
RAYMOND L. HINTZ
Keyword(s):  
Insulin Resistance ◽  
Growth Hormone ◽  
Human Growth Hormone ◽  
Recombinant Dna ◽  
Human Growth ◽  
Human Pituitary ◽  
Pituitary Growth Hormone

Comparison of methionyl human growth hormone and pituitary growth hormone on somatic growth of hypophysectomized rats

1984 ◽  
Vol 107 (2) ◽  
pp. 192-198 ◽  
Author(s):  
A. Skottner ◽  
A. Forsman ◽  
E. Löfberg ◽  
K.-G. Thorngren
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Bone Growth ◽  
Biological Effects ◽  
Human Growth ◽  
Male Rats ◽  
Cartilage Growth ◽  
Human Pituitary ◽  
Longitudinal Bone Growth ◽  
Pituitary Growth Hormone

Abstract. In hypophysectomized male rats the biological effects of two batches of methionyl human growth hormone, Somatonorm®, (met-hGH), have been compared to those of human pituitary growth hormone, Crescormon® (hGH). The rats were treated with doses ranging from 10 mIU per day to 145 mIU per day for 10 days. The parameters studied were total weight gain, longitudinal bone growth, measured by the tetracycline method and indirect cartilage growth, measured by uptake of radioactive sulphate. The results obtained demonstrated that Somatonorm® stimulated weight increase in a linear and dose-dependent way, similar to that seen with the native hormone. Longitudinal bone growth, measured by the tetracycline method and the growth of different cartilages, measured as uptake of radioactive sulphate, were also similar between the two hormones.

Hyperglycemic Activity in Dogs of Recombinant DNA-Derived 20,000 Dalton Variant of Methionyl Human Growth Hormone

1986 ◽  
Vol 12 (1) ◽  
pp. 21-35 ◽  
Author(s):  
C. J. Shaar ◽  
E. L. Grinnan ◽  
W. G. Short ◽  
J. G. Powell ◽  
N. Bryan ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Recombinant Dna ◽  
Human Growth

Immunoassay for the detection of E. coli proteins in recombinant DNA derived human growth hormone

1986 ◽  
Vol 91 (2) ◽  
pp. 213-224 ◽  
Author(s):  
Vincent R. Anicetti ◽  
Eileen F. Fehskens ◽  
Baron R. Reed ◽  
Anthony B. Chen ◽  
Polly Moore ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Recombinant Dna ◽  
Human Growth ◽  
E Coli
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