Plasma amino acid ratios related to brain serotonin synthesis in response to food intake in bulimia nervosa

1995 ◽  
Vol 38 (10) ◽  
pp. 659-668 ◽  
Author(s):  
Hanno Pijl ◽  
Adam F. Cohen ◽  
Robbert J. Verkes ◽  
Hans P.F. Koppeschaar ◽  
Jolein A. Iestra ◽  
...  
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Bulimia Nervosa ◽  
Plasma Amino Acid ◽  
Brain Serotonin ◽  
Serotonin Synthesis

Dietary intake of tryptophan tied emotion-related impulsivity in humans

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Florian Javelle ◽  
Descartes Li ◽  
Philipp Zimmer ◽  
Sheri L. Johnson
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Food Intake ◽  
Essential Amino Acid ◽  
Food Habits ◽  
Psychological Disorder ◽  
Serotonin Synthesis ◽  
Amino Acid Tryptophan ◽  
Pass Through ◽  
Three Factor

Abstract. Emotion-related impulsivity, defined as the tendency to say or do things that one later regret during periods of heightened emotion, has been tied to a broad range of psychopathologies. Previous work has suggested that emotion-related impulsivity is tied to an impaired function of the serotonergic system. Central serotonin synthesis relies on the intake of the essential amino acid, tryptophan and its ability to pass through the blood brain barrier. Objective: The aim of this study was to determine the association between emotion-related impulsivity and tryptophan intake. Methods: Undergraduate participants (N = 25, 16 women, 9 men) completed a self-rated measure of impulsivity (Three Factor Impulsivity Index, TFI) and daily logs of their food intake and exercise. These data were coded using the software NutriNote to evaluate intakes of tryptophan, large neutral amino acids, vitamins B6/B12, and exercise. Results: Correlational analyses indicated that higher tryptophan intake was associated with significantly lower scores on two out of three subscales of the TFI, Pervasive Influence of Feelings scores r =  –.502, p < . 010, and (lack-of) Follow-Through scores, r =  –.407, p < . 050. Conclusion: Findings provide further evidence that emotion-related impulsivity is correlated to serotonergic indices, even when considering only food habits. It also suggests the need for more research on whether tryptophan supplements might be beneficial for impulsive persons suffering from a psychological disorder.

Food intake: Regulation by plasma amino acid pattern

Life Sciences ◽  
1969 ◽  
Vol 8 (2) ◽  
pp. 1-9 ◽  
Author(s):  
Philip M-B. Leung ◽  
Quinton R. Rogers
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Amino Acid Pattern ◽  
Plasma Amino Acid ◽  
Food Intake Regulation ◽  
Intake Regulation

Amino Acid Imbalance and Diet Preference in the Hypothalamic–Hyperphagic Rat

1971 ◽  
Vol 49 (8) ◽  
pp. 752-757 ◽  
Author(s):  
S. M. Arakawa ◽  
B. R. Standal ◽  
J. R. Beaton
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Diet Selection ◽  
Amino Acid Pattern ◽  
Plasma Amino Acid ◽  
Diet Preference ◽  
Amino Acid Imbalance ◽  
Satiety Center

Diet selection by control and hypothalamic–hyperphagic rats was recorded to examine the hypothesis that the plasma amino acid pattern may act as a satiety signal with respect to the decreased food intake associated with amino acid unbalanced diets. Rats were offered choices between: (a) protein-free and imbalanced diets; (b) imbalanced and corrected diets; (c) corrected and basal diets. Although selection by control and operated rats differed with respect to choice a, selection behaviors were comparable for choices b and c. Plasma amino acid patterns were similar in control and operated rats indicating that the same potential satiety signal was present in both groups. Since the "satiety center" was ablated in operated rats, it would seem that if plasma amino acid patterns serve as a satiety signal, this signal must act in some manner other than on the ventromedial area of the hypothalamus.

Experimental Uraemia with Associated Plasma Amino Acid Abnormalities but without Retarded Food Intake and Weight Gain

Nephron ◽  
1989 ◽  
Vol 53 (3) ◽  
pp. 233-237 ◽  
Author(s):  
D.J. Haines ◽  
C.H.J. Swan ◽  
J.R.B. Green ◽  
J.F. Woodley
Keyword(s):  
Weight Gain ◽  
Amino Acid ◽  
Food Intake ◽  
Plasma Amino Acid

scholarly journals Tryptophan Depletion Increases Nausea, Headache and Photophobia in Migraine Sufferers

Cephalalgia ◽  
2006 ◽  
Vol 26 (10) ◽  
pp. 1225-1233 ◽  
Author(s):  
PD Drummond
Keyword(s):  
Amino Acid ◽  
Motion Sickness ◽  
Pain Sensitivity ◽  
Brain Serotonin ◽  
Tryptophan Depletion ◽  
Serotonin Synthesis ◽  
Acid Condition ◽  
Short Term

Sensitivity to light was investigated 5 and 8 h after consumption of an amino acid drink which contained L-tryptophan (balanced amino acid condition: 19 controls and 22 migraine sufferers) or which produced a short-term reduction in brain serotonin synthesis by omitting L-tryptophan (tryptophan depletion condition: 16 controls and 16 migraine sufferers). Migraine sufferers reported more intense nausea, headache, glare- and light-induced pain than controls. In addition, glare- and light-induced pain were greater in the tryptophan depletion condition than in the balanced amino acid condition, in both migraine sufferers and controls. Eight hours after the amino acid drink, after participants had completed tests of pain sensitivity and motion sickness provocation, tryptophan depletion augmented headache in migraine sufferers and aggravated nausea in migraine sufferers and controls. These findings suggest that a reduction in brain synthesis of serotonin intensifies photophobia and other migrainous symptoms and thus might contribute to the pathogenesis of migraine.

Sign in / Sign up

Export Citation Format

Share Document