Dissociated effects of thymectomy at weaning on T-cell-mediated responses in vitro: Correction by the serum thymic factor, FTS, and its analogs

1981 ◽  
Vol 64 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Dominique Kaiserlian ◽  
Mireille Dardenne ◽  
Jean-François Bach
1978 ◽  
Vol 159 (2) ◽  
pp. 195-200 ◽  
Author(s):  
D. Martinez ◽  
A. K. Field ◽  
H. Schwam ◽  
A. A. Tytell ◽  
M. R. Hilleman

Author(s):  
H. Alasam

The possibility that intrathymic T-cell differentiation involves stem cell-lymphoid interactions in embryos led us to study the ultrastructure of epithelial cell in normal embryonic thymus. Studies in adult thymus showed that it produces several peptides that induce T-cell differentiation. Several of them have been chemically characterized, such as thymosin α 1, thymopoietin, thymic humoral factor or the serum thymic factor. It was suggested that most of these factors are secreted by populations of A and B-epithelial cells.Embryonic materials were obtained from inbred matings of Swiss Albino mice. Thymuses were disected from embryos 17 days old and prepared for transmission electron microscopy. Our studies showed that embryonic thymus at this stage contains undifferentiated and differentiated epithelial cells, large lymphoblasts, medium and few small lymphocytes (Fig. 5). No differences were found between cortical and medullary epithelial cells, in contrast to the findings of Van Vliet et al,. Epithelial cells were mostly of the A-type with low electron density in both cytoplasm and nucleus. However few B-type with high electron density were also found (Fig. 7).


2020 ◽  
Author(s):  
Satsuki Murakami ◽  
Susumu Suzuki ◽  
Ichiro Hanamura ◽  
Kazuhiro Yoshikawa ◽  
Ryuzo Ueda ◽  
...  

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