High concentrations of lipoprotein(a) as a risk factor for coronary heart disease and hypertension in type II diabetic patients

Background Lipoprotein(a) [Lp(a)] is a risk factor for atherosclerosis and increases with age. The purpose of this study was to determine the effect of ageing on Lp(a) for three different apo(a) phenotypes. Methods We measured plasma Lp(a) concentrations in 551 unrelated Japanese subjects (20-88 years of age). We performed statistical analyses separately for three apo(a) phenotypes: the low-molecular-weight (LMW) phenotype with the F, B or S1 isoform, the intermediate-molecular-weight (IMW) phenotype with the S2 isoform and the high-molecular-weight (HMW) phenotype with the S3 or S4 isoform. Results For each phenotype, the mean plasma Lp(a) concentration and the frequency of Lp(a) concentrations ≥ 250 mg/L increased with age. Further, a statistically significant difference was always found between the younger subjects (20-39 years of age) and the elderly (over 60 years). The frequency of coronary heart disease increased with age, particularly for the LMW and IMW phenotypes. Conclusions We conclude that ageing elevates plasma Lp(a) concentrations, which may have a role in the prevalence of coronary heart disease in the elderly, especially those with the LMW or IMW phenotypes.

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2.P.111 Elevated lipoprotein (a) levels and coronary heart disease: Differences between non-insulin-dependent diabetic patients and nondiabetic subjects

Atherosclerosis ◽

10.1016/s0021-9150(97)88748-5 ◽

1997 ◽

Vol 134 (1-2) ◽

pp. 139

Author(s):

P.B. Djordjević ◽

K. Lalić ◽

D. Bošković ◽

N.M. Lalić ◽

M. Zamaklar ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Diabetic Patients ◽

Lipoprotein A ◽

Insulin Dependent ◽

Insulin Dependent Diabetic

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Lipoprotein(a) as a Risk Factor for Coronary Heart Disease : Whether Related with NIDDM or Not

Korean Circulation Journal ◽

10.4070/kcj.1996.26.2.507 ◽

1996 ◽

Vol 26 (2) ◽

pp. 507 ◽

Cited By ~ 2

Author(s):

Si Hoon Park ◽

Gil Ja Shin

Keyword(s):

Coronary Heart Disease ◽

Risk Factor ◽

Heart Disease ◽

Lipoprotein A

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Lipoprotein(a) in coronary heart disease. Is it a risk factor after all?

JAMA ◽

10.1001/jama.271.13.1025 ◽

1994 ◽

Vol 271 (13) ◽

pp. 1025-1026 ◽

Cited By ~ 4

Author(s):

V. Gurewich

Keyword(s):

Coronary Heart Disease ◽

Risk Factor ◽

Heart Disease ◽

Lipoprotein A

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Asymmetric and symmetric dimethylarginine in patients presenting with risk factors for coronary heart disease

Open Medicine ◽

10.2478/s11536-012-0031-y ◽

2012 ◽

Vol 7 (5) ◽

pp. 659-664

Author(s):

Marina Ilic ◽

Radmila Pavlovic ◽

Gordana Lazarevic ◽

Tatjana Cvetkovic ◽

Gordana Kocic ◽

...

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Risk Factor ◽

Heart Disease ◽

Diabetic Patients ◽

Healthy Controls ◽

Middle Aged ◽

Control Groups ◽

Symmetric Dimethylarginine ◽

Patient Groups

AbstractThe aim of the present study was to investigate asymmetric (ADMA) and symmetric dimethylarginine (SDMA) production in patients presenting with one or more risk factor (RF) for coronary heart disease (CHD). Patients and methods: Overall, 113 participants were enrolled in the study, including 45 patients presenting with risk for CHD (27 male and 18 female; aged 55.9 ± 6.4 years), 30 sex and age-matched middle-aged healthy controls (16 male and 14 female; aged 56.3 ± 8.4 years), and 38 young healthy controls (38 male; aged 24.6 ± 3.9 years). Results: No significant differences for ADMA and SDMA were recorded between patients groups presenting with risk for CHD. However, ADMA and SDMA were significantly higher in all examined patient groups (≥3 and 1–2 RF, hypertensive and non-hypertensive, obese and non-obese, diabetics and non-diabetics) compared with both control groups (middle-aged and young controls) (p<0.001). ADMA significantly correlated with SDMA in ≥3 RF (p<0.05), hypertensive (p<0.05), non-obese (p<0.05), non-diabetics (p<0.01), as well in middle-aged (p<0.05) and young controls (p<0.001). Conclusion: Significantly higher ADMA and SDMA were found between patients presenting with risk for CHD (≥3 and 1–2 RF, hypertensive and nonhypertensive, obese and non-obese, diabetics and non-diabetics) and healthy, middle-aged and young controls. ADMA significantly correlated with SDMA in ≥3 RF, hypertensive, non-obese and non-diabetic patients, as well as in middle-aged and young controls.

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Macroangiopathy in type II diabetes

Acta Endocrinologica ◽

10.1530/acta.0.104s075 ◽

1983 ◽

Vol 104 (4_Suppl) ◽

pp. S75-S78

Author(s):

Antti Aro

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Vascular Disease ◽

Peripheral Vascular Disease ◽

Type Ii Diabetes ◽

Clinical Manifestations ◽

Diabetic Patients ◽

Type Ii ◽

Peripheral Vascular ◽

Middle Aged

ABSTRACT. Macroangiopathy is the most important cause of mortality and morbidity in type II diabetes. The atherosclerotic process in diabetes is similar to that found in non-diabetic subjects, but the laesions are more extensive and the clinical manifestations are more common in diabetic subjects than in the non-diabetic population. In diabetic patients from different populations, the prevalence of macroangiopathy is variable, and the relative frequency follows the pattern found in the respective non-diabetic populations. The relative risk of large vessel disease is in most populations higher for female than for male diabetics. Coronary heart disease is the most important manifestation of macroangiopathy while cerebrovascular disease and peripheral vascular disease are less frequent, although all these manifestations occur at increased frequency among middle-aged diabetic subjects. The incidence of peripheral vascular disease seems to increase with increasing duration of diabetes in middle-aged subjects, whereas coronary heart disease is particularly frequent in type II diabetes already at the time of the diagnosis. Key words: atherosclerosis, complications, diabetes mellitus, macroangiopathy, mortality.

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