The relationship of dopamine receptor blockade to clinical response in schizophrenic patients treated with pimozide or haloperidol

1984 ◽  
Vol 18 (3) ◽  
pp. 255-268 ◽  
Author(s):  
Trevor Silverstone ◽  
John Cookson ◽  
Rosemary Ball ◽  
Cheuk Ngen Chin ◽  
David Jacobs ◽  
...  
Keyword(s):  
Clinical Response ◽  
Dopamine Receptor ◽  
Receptor Blockade ◽  
Schizophrenic Patients ◽  
Relationship Of ◽  
The Relationship

Relevance of the dopamine D2 receptor blockade in clinical response to neuroleptic treatment in schizophrenic patients

1989 ◽  
Vol 2 (1-2) ◽  
pp. 207
Author(s):  
Ana Hitri ◽  
Parvathi Mohan ◽  
Dharmber Sinha ◽  
James Harrold ◽  
BruceI. Diamond ◽  
...  
Keyword(s):  
Clinical Response ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Blockade ◽  
Neuroleptic Treatment ◽  
Dopamine D2 ◽  
Schizophrenic Patients

Family Management Programmes for Schizophrenic Patients

1989 ◽  
Vol 155 (S5) ◽  
pp. 112-116 ◽  
Author(s):  
Kurt Hahlweg ◽  
Eli Feinstein ◽  
Ursula Müller ◽  
Matthias Dose
Keyword(s):  
Expressed Emotion ◽  
Causal Role ◽  
Family Management ◽  
New Techniques ◽  
Schizophrenic Psychosis ◽  
Schizophrenic Patients ◽  
Family Variables ◽  
Relationship Of ◽  
The Relationship

Hypotheses on the relationship of schizophrenia and family variables have changed considerably over the last 15 years: whereas speculations on the causal role of familial interaction for the onset of schizophrenic psychosis previously dominated the field of psychological theorising and psychotherapy (Bateson et al, 1956), it was not possible to confirm these theories empirically. In accordance with the research on Expressed Emotion (EE), a shift in emphasis to the influence of family variables on the further course of the illness has taken place. As a consequence, promising new techniques have been developed for the prevention or postponement of relapse.

The Relationship of Schizophrenic Births to 16 Infectious Diseases

1994 ◽  
Vol 165 (3) ◽  
pp. 353-356 ◽  
Author(s):  
E. O'Callaghan ◽  
P. C. Sham ◽  
N. Takei ◽  
G. Murray ◽  
G. Glover ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Poisson Regression ◽  
The Other ◽  
Data Sets ◽  
Poisson Regression Model ◽  
England And Wales ◽  
Schizophrenic Patients ◽  
Relationship Of ◽  
The Relationship ◽  
First Admission

BackgroundRecently, several investigators have reported an association between influenza epidemics and increased birth rates of ‘preschizophrenic’ individuals some four to six months later. Here we examine whether maternal exposure to other infectious diseases can also predispose the foetus to later schizophrenia.MethodTwo independent sets of dates of birth of first admission schizophrenic patients, born between 1938 and 1965 in England and Wales, were obtained from the Mental Health Enquiry in England and Wales. Data on the number of deaths per month from 16 infectious diseases between 1937 and 1965 in England and Wales were also collected. We used a Poisson regression model to examine the relationship between deaths from infectious diseases and schizophrenic births.ResultsIn the two separate data sets, increased national deaths from bronchopneumonia preceded, by three and five months respectively, increased numbers of schizophrenic births. We did not find any other significant associations between schizophrenic births and any of the other 15 infectious diseases.ConclusionsThe association between deaths from bronchopneumonia and increased schizophrenic births some months later may be a reflection of the fact that bronchopneumonia deaths increase markedly during influenza epidemics.

Family History of Schizophrenia and the Relationship of Stress to Symptoms: Preliminary Findings

2001 ◽  
Vol 35 (2) ◽  
pp. 217-223 ◽  
Author(s):  
Ross M. G. Norman ◽  
Ashok K. Malla
Keyword(s):  
Family History ◽  
Negative Affect ◽  
Negative Symptoms ◽  
Positive Family History ◽  
Positive Symptoms ◽  
Daily Stressors ◽  
Schizophrenic Patients ◽  
History Of ◽  
Relationship Of ◽  
The Relationship

Objective: It has been hypothesized that patients with a diagnosis of schizophrenia who have a positive family history for schizophrenia will show greater reactivity of their symptoms to increasing levels of stress or negative affect than will patients without such a family history. In the past this hypothesis has only been tested through manipulations of negative affect in laboratory settings. In this paper we test this hypothesis using longitudinal clinical data. Method: Data were derived from an earlier longitudinal study using monthly assessments of daily stressors (Hassles Scale) and symptom measures (the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms). We compared longitudinal stress to symptom relations in 12 patients with schizophrenia for whom a positive family history of schizophrenia could be identified with 12 matched schizophrenic patients without any known family history of psychiatric illness. Results: There was evidence that patients with a family history of schizophrenia demonstrated a stronger relation between stress and total score on the Scale for the Assessment of Positive Symptoms. This difference appears to have primarily reflected a greater reactivity to stress of reality distortion symptoms in the positive family history group. The two groups did not differ in apparent reactivity to stress of the disorganization and psychomotor poverty dimensions of symptomatology. Conclusions: The results of this study provide support from a naturalistic, longitudinal clinical study for the hypothesis that reactivity to stress of some symptoms of schizophrenia may vary as a function of family history of the disorder.

The relationship of PET D2 dopamine receptor findings to superior temporal gyral volume estimates in 14 schizophrenic subjects

1992 ◽  
Vol 6 (2) ◽  
pp. 147-148
Author(s):  
LarryE. Tune ◽  
GodfreyD. Pearlson ◽  
PatrickE. Barta ◽  
RichardE. Powers ◽  
DeanF. Wong
Keyword(s):  
Dopamine Receptor ◽  
D2 Dopamine Receptor ◽  
Relationship Of ◽  
Volume Estimates ◽  
The Relationship

Depression, Affect and Negative Symptoms in Schizophrenia

1989 ◽  
Vol 155 (S7) ◽  
pp. 108-114 ◽  
Author(s):  
J.-P. Lindenmayer ◽  
Stanley R. Kay
Keyword(s):  
Negative Symptoms ◽  
Full Range ◽  
Large Body ◽  
Considerable Difficulty ◽  
Schizophrenic Patients ◽  
Detailed Assessment ◽  
Affect States ◽  
Relationship Of ◽  
Prospective Longitudinal ◽  
The Relationship

The relationship of depression with affect deficit in schizophrenic patients continues to challenge both the clinician and the researcher. Often there is considerable difficulty in differentiating these two affect states in a reliable and valid fashion. On the observational level, depressed affect often appears somewhat restricted, having lost the full range of the euthymic state. On a subjective level, schizophrenic patients often complain of anhedonia, a defect in pleasure capacity which is shared by patients who are depressed. On the prognostic level, there is a large body of literature that links depressive features in acute schizophrenics to favourable subsequent course (Astrup & Noreik, 1966; Vaillant, 1964). We were, therefore, interested in investigating the relationship of depression with impaired affect and with positive/negative symptoms in young acute schizophrenic patients. We used a systematic multidimensional study of affect impairment among 37 young acute schizophrenic patients in a prospective, longitudinal approach over a 2-year span. In addition to a detailed assessment of the affect profile, including depression, both at baseline and on follow-up, we rated patients clinically for a positive and negative syndrome as well as general psychopathology, and we conducted premorbid and outcome measurements.

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