Study on the relationship among dose, concentration and clinical response in Chinese schizophrenic patients treated with Amisulpride

2021 ◽  
pp. 102694
Author(s):  
Fengli Sun ◽  
Fang Yu ◽  
Zhihan Gao ◽  
Zhibin Ren ◽  
Weidong Jin
Keyword(s):  
Clinical Response ◽  
Dose Concentration ◽  
Schizophrenic Patients ◽  
The Relationship

The relationship of dopamine receptor blockade to clinical response in schizophrenic patients treated with pimozide or haloperidol

1984 ◽  
Vol 18 (3) ◽  
pp. 255-268 ◽  
Author(s):  
Trevor Silverstone ◽  
John Cookson ◽  
Rosemary Ball ◽  
Cheuk Ngen Chin ◽  
David Jacobs ◽  
...  
Keyword(s):  
Clinical Response ◽  
Dopamine Receptor ◽  
Receptor Blockade ◽  
Schizophrenic Patients ◽  
Relationship Of ◽  
The Relationship

Epidemiological Evidence that Maternal Influenza Contributes to the Aetiology of Schizophrenia

1993 ◽  
Vol 163 (4) ◽  
pp. 522-534 ◽  
Author(s):  
W. Adams ◽  
R. E. Kendell ◽  
E. H. Hare ◽  
P. Munk-Jørgensen
Keyword(s):  
Data Sets ◽  
Time Lags ◽  
Epidemiological Evidence ◽  
Intrauterine Development ◽  
Increased Risk ◽  
Schizophrenic Patients ◽  
The Relationship ◽  
Monthly Incidence ◽  
Maternal Influenza

The epidemiological evidence that the offspring of women exposed to influenza in pregnancy are at increased risk of schizophrenia is conflicting. In an attempt to clarify the issue we explored the relationship between the monthly incidence of influenza (and measles) in the general population and the distribution of birth dates of three large series of schizophrenic patients - 16 960 Scottish patients born in 1932–60; 22 021 English patients born in 1921–60; and 18 723 Danish patients born in 1911–65. Exposure to the 1957 epidemic of A2 influenza in midpregnancy was associated with an increased incidence of schizophrenia, at least in females, in all three data sets. We also confirmed the previous report of a statistically significant long-term relationship between patients' birth dates and outbreaks of influenza in the English series, with time lags of - 2 and - 3 months (the sixth and seventh months of pregnancy). Despite several other negative studies by ourselves and others we conclude that these relationships are probably both genuine and causal; and that maternal influenza during the middle third of intrauterine development, or something closely associated with it, is implicated in the aetiology of some cases of schizophrenia.

Insight and aggressive Behavior in acute Schizophrenic Patients

2016 ◽  
Vol 33 (S1) ◽  
pp. S441-S441
Author(s):  
S. Campi ◽  
C. Esposito ◽  
P. andreassi ◽  
P. Bandinelli ◽  
P. Girardi ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Treatment Compliance ◽  
Aggressive Behaviors ◽  
Self Monitoring ◽  
Poor Treatment ◽  
Schizophrenic Patients ◽  
Competing Interest ◽  
The Relationship ◽  
Acute Patients

Introductionaggressive behavior in wards is associated to poor treatment compliance and low clinical insight. Most studies focused on the clinical and cognitive dimensions of insight, while the relationship between metacognitive dimension and aggressive behaviors was not investigated. Our aim was to understand what relationship occurs between dimensions of insight (metacognitive, cognitive, clinical), and specific aggressive behaviors in acute patients.Methodswe recruited 75 acute schizophrenic patients using: aQ; MO aS; IS; P aNSS; BCIS.Resultsa positive correlation between the IS score and the hostility, angry and physical aggression sub-scores of the aQ was highlighted, while no correlation between the score of IS and MO aS total score was found. No correlation between the score of the P aNSS G12 item and the aQ scores and MO aS was found, and no correlation between BCIS scores, MO aS and aQ scores was found.Conclusionsin our patients, a higher level of metacognitive insight, but not clinical nor cognitive insight, was associated to higher levels of hostility. we suggest that a higher ability to monitor and appraise one's own altered processes of thought and related discomfort, feeling of destabilization and loss of control, could contribute to enhance resentment and suspiciousness. Findings help develop specific therapeutic strategies to enhance metacognitive and self-monitoring abilities, helping patient's understanding of the illness, improving compliance with treatment, and patient's quality of life. Our results support the multidimensional nature of insight in schizophrenia, confirming that clinical, cognitive and metacognitive dimensions are independent though related facets of the phenomenon of insight in schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

The Empirical Heterogeneity of First Rank Symptoms in Schizophrenia

1982 ◽  
Vol 140 (5) ◽  
pp. 498-502 ◽  
Author(s):  
Richard Lewine ◽  
Robin Renders ◽  
Mark Kirchhofer ◽  
Ann Monsour ◽  
Norman Watt
Keyword(s):  
Psychiatric Symptoms ◽  
Empirical Studies ◽  
Reliability And Validity ◽  
Homogeneous Group ◽  
Schizophrenic Patients ◽  
First Rank Symptoms ◽  
The Relationship

SummaryFirst rank symptoms have assumed an important role in the assessment of schizophrenia. Only recently, however, have there been empirical studies of their reliability and validity. In this study, we examined the relationship between first rank and other psychiatric symptoms in 100 schizophrenic patients. The results are consistent with other research reports suggesting that first rank symptoms do not represent a homogeneous group of symptoms within an individual patient.

Relevance of the dopamine D2 receptor blockade in clinical response to neuroleptic treatment in schizophrenic patients

1989 ◽  
Vol 2 (1-2) ◽  
pp. 207
Author(s):  
Ana Hitri ◽  
Parvathi Mohan ◽  
Dharmber Sinha ◽  
James Harrold ◽  
BruceI. Diamond ◽  
...  
Keyword(s):  
Clinical Response ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Blockade ◽  
Neuroleptic Treatment ◽  
Dopamine D2 ◽  
Schizophrenic Patients

Unravelling the Relationship between Genetic and Environmental Risk Factors in Psychiatric Disorders

1987 ◽  
Vol 151 (3) ◽  
pp. 302-305 ◽  
Author(s):  
L. R. Goldin ◽  
L. E. DeLisi ◽  
E. S. Gershon
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Head Injuries ◽  
Biological Traits ◽  
Normal Range ◽  
Birth Complications ◽  
Schizophrenic Patients ◽  
Sporadic Cases ◽  
Brain Changes ◽  
The Relationship

Murray et al (1985) have proposed a method for using biological markers and information about family history to reduce the heterogeneity in a disease such as schizophrenia. They propose that families which are heavily loaded with illness are most likely to be segregating for a major locus and therefore should be used for studies of genetic marker or other biological traits that are thought to be related to a genetic etiology. They propose that patients without a family history (sporadics) of an illness should be investigated for hypothesised environmental components since they are the cases where environmental factors are most likely to play a large role. They give an example from their own data on Ventricular Brain Ratios (VBR) in a sample of schizophrenic twins (Reveley et al, 1984) where schizophrenic twins without any family history (FH-) of a major psychosis had significantly larger ventricles than did schizophrenic twins with a family history (FH+). They conclude that while there is a genetic determinant to ventricular size within the normal range, large ventricles reflect an environmental aetiology that is more important in sporadic cases than in those with a familial pattern to the illness. Subsequently, Reveley & Chitkara (1985) found that singleton schizophrenic patients who were FH-had a significantly larger VBR than did controls while FH+ patients had a mean midway between FH-patients and controls. While this is an attractive hypothesis for the structural brain changes seen in some schizophrenic patients, results of other studies are not consistent with these findings (Nasrallah et al, 1983; Schulsinger et al, 1984; Owens et al, 1985; DeLisi et al, 1986). For example, in our own data (DeLisi et al, 1986), ‘familial’ schizophrenics had larger ventricles than did controls and risk factors thought to be environmental (head injuries and birth complications) were found to be present in that sample.

Schizophrenia and family rituals: measuring family rituals among schizophrenics and “normals”

1994 ◽  
Vol 9 (1) ◽  
pp. 45-51 ◽  
Author(s):  
MG Madianos ◽  
M Economou
Keyword(s):  
Collective Identity ◽  
Psychosocial Functioning ◽  
Normal Families ◽  
Family Rituals ◽  
Global Assessment Scale ◽  
Therapeutic Implications ◽  
Symbolic Communication ◽  
Scale Scores ◽  
Schizophrenic Patients ◽  
The Relationship

SummaryFamily rituals consisting of ceremonial acts, traditions and patterned interactions serve as a basis of communication, collective identity, and stabilizing relationships. Therefore, the measurement of rituals in a schizophrenic family is an objectification of the family's symbolic communication and integration. Based upon this, the relationship between family rituals practice in 138 families both with a schizophrenic member (71) and without (67) was examined by the use of an originally developed instrument, the “Family Rituals Scale” (FRS). The psychometric properties of this instrument were tested and proved to be reliable. Families with a schizophrenic member were less ritualizing than the “normal” families. The correlation between FRS scores and Global Assessment Scale scores in schizophrenic patients was negative (the higher the psychosocial functioning level, the lower FRS scores), which means a higher performance of family rituals. The effect of other factors on FRS scores and the therapeutic implications are discussed.

Family Management Programmes for Schizophrenic Patients

1989 ◽  
Vol 155 (S5) ◽  
pp. 112-116 ◽  
Author(s):  
Kurt Hahlweg ◽  
Eli Feinstein ◽  
Ursula Müller ◽  
Matthias Dose
Keyword(s):  
Expressed Emotion ◽  
Causal Role ◽  
Family Management ◽  
New Techniques ◽  
Schizophrenic Psychosis ◽  
Schizophrenic Patients ◽  
Family Variables ◽  
Relationship Of ◽  
The Relationship

Hypotheses on the relationship of schizophrenia and family variables have changed considerably over the last 15 years: whereas speculations on the causal role of familial interaction for the onset of schizophrenic psychosis previously dominated the field of psychological theorising and psychotherapy (Bateson et al, 1956), it was not possible to confirm these theories empirically. In accordance with the research on Expressed Emotion (EE), a shift in emphasis to the influence of family variables on the further course of the illness has taken place. As a consequence, promising new techniques have been developed for the prevention or postponement of relapse.

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