Direct effect of plasma sex hormone binding globulin (SHBG) on the metabolic clearance rate of 17β-estradiol in the primate

1990 ◽  
Vol 36 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Stephen R. Plymate ◽  
Pearl C. Namkung ◽  
Louis A. Metej ◽  
Philip H. Petra
Keyword(s):  
Direct Effect ◽  
Clearance Rate ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Metabolic Clearance ◽  
Hormone Binding ◽  
Metabolic Clearance Rate ◽  
17Β Estradiol

RELATION BETWEEN SEX HORMONE BINDING GLOBULIN AND D-NORGESTREL LEVELS IN PLASMA

1977 ◽  
Vol 86 (2) ◽  
pp. 430-436 ◽  
Author(s):  
Arne Victor ◽  
Erik Weiner ◽  
Elof D. B. Johansson
Keyword(s):  
Oral Contraceptives ◽  
Plasma Levels ◽  
Significant Positive Correlation ◽  
Treatment Cycle ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Metabolic Clearance ◽  
Hormone Binding ◽  
Metabolic Clearance Rate

ABSTRACT In order to investigate the effect of changes in sex hormone binding globulin (SHBG) levels on d-norgestrel (d-Ng) levels in plasma, the plasma levels of SHBG and d-Ng were studied during one treatment cycle in 6 women on oral contraceptives containing d-Ng and ethinyloestradiol (EOe2) and in 3 women using subcutaneous silastic rods containing d-Ng concomitantly taking EOe2 for three weeks. A significant positive correlation between the SHBG and d-Ng levels was found in 7 of the 9 subjects studied. The results provide evidence for an in vivo binding of d-Ng to SHBG, a SHBG influence on the metabolic clearance rate of d-Ng and consequently a dependence of the plasma levels of d-Ng on the SHBG concentrations in the plasma. These findings support the concept that the clinically and biochemically observed anti-oestrogenic/androgenic effects observed in women on d-Ng containing medication are due to a displacement of testosterone from SHBG by d-Ng.

Peripheral hormone levels in healthy subjects during controlled fasting

1986 ◽  
Vol 113 (3) ◽  
pp. 457-462 ◽  
Author(s):  
Ragnar Tegelman ◽  
Pia Lindeskog ◽  
Kjell Carlström ◽  
Åke Pousette ◽  
Rolf Blomstrand
Keyword(s):  
Protein Binding ◽  
Testosterone Level ◽  
Healthy Subjects ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Metabolic Clearance ◽  
Dehydroepiandrosterone Sulphate ◽  
Hormone Binding

Abstract. The effect of one week of controlled fasting (3 1 of fluid containing 50 g of carbohydrate/day) upon the serum levels of hormones, sex hormone binding globulin, and albumin was studied in healthy subjects. Fasting caused decreased levels of prolactin and T3, no changes in the levels of TSH, FSH, LH, dehydroepiandrosterone, 4-androstene-3,17-dione, total oestrone, and total testosterone, and increased levels of cortisol, dehydroepiandrosterone sulphate and albumin. A significant positive correlation was found between albumin and dehydroepiandrosterone sulphate. Fasting rapidly increased the levels of sex hormone binding globulin and decreased the percentage of free testosterone and the calculated free testosterone level in both sexes. A decreased metabolic clearance of certain steroids (cortisol, dehydroepiandrosterone sulphate) owing to an increased protein binding may be one of the endocrine consequences of fasting. An increased protein binding of testosterone may be outweighed by a decreased gonadal production, thus resulting in an unchanged total testosterone level. The increased sex hormone binding globulin level could not be explained by changes in gonadal and thyroid hormones.

Androgen and oestrogen dynamics in hyperthyroidism

1982 ◽  
Vol 95 (1) ◽  
pp. 105-115 ◽  
Author(s):  
E. C. Ridgway ◽  
Farahe Maloof ◽  
Christopher Longcope
Keyword(s):  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Metabolic Clearance ◽  
Hormone Binding ◽  
Clearance Rates ◽  
Production Rates ◽  
Normal Range

Using constant infusions of [3H]testosterone and [14C]oestradiol or [3H]androstenedione and [14C]oestrone the dynamics of androgen and oestrogen metabolism and production in patients with hyperthyroidism were measured. The metabolic clearance rates of testosterone and oestradiol were decreased but those of androstenedione and oestrone were within the normal range. The conversion ratios of testosterone to androstenedione and of testosterone to dihydrotestosterone (DHT) were decreased whereas those of androstenedione to testosterone and androstenedione to DHT were increased. These changes could be explained by increased serum levels of sex hormone binding globulin which binds testosterone and DHT but not androstenedione. The fraction of androstenedione infused into and measured as oestrone in the blood was normal in seven out of nine subjects and the fraction of testosterone infused and measured as oestradiol was normal in all nine subjects. The production rates of testosterone and oestradiol were in the normal range but the production rates of androstenedione and oestrone were raised in half the subjects.

A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*

1991 ◽  
Vol 72 (1) ◽  
pp. 83-89 ◽  
Author(s):  
JOHN E. NESTLER ◽  
LINDA P. POWERS ◽  
DENNIS W. MATT ◽  
KENNETH A. STEINGOLD ◽  
STEPHEN R. PLYMATE ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Direct Effect ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Obese Women ◽  
Hormone Binding ◽  
Ovary Syndrome

Binding of Phytoestrogens to Rat Uterine Estrogen Receptors and Human Sex Hormone-binding Globulins

2005 ◽  
Vol 60 (7-8) ◽  
pp. 649-656 ◽  
Author(s):  
Pablo Ibieta Hillerns ◽  
Yuangang Zu ◽  
Michael Wink
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
Conformational Changes ◽  
Nordihydroguaiaretic Acid ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Scatchard Analysis ◽  
Binding Affinities ◽  
Hormone Binding ◽  
17Β Estradiol

The interaction of phytoestrogens with the most important binding sites of steroid hormones, i.e. sex hormone-binding globulin and estrogen receptors, was investigated. Relative binding affinities and association constants for 21 compounds among them isoflavones, flavones, flavonols, flavanones, chalcones and lignans were determined. The lignan nordihydroguaiaretic acid weakly displaced 17β-[3H]-estradiol from estrogen receptor and Scatchard analysis suggests non-conformational changes. Compounds from Glycyrrhiza glabra, liquiritigenin and isoliquiritigenin, showed estrogenic affinities to both receptors. 18β-Glycyrrhetinic acid displaced 17β-[3H]-estradiol from sex hormone-binding globulin but not from the estrogen receptor. Phytoestrogens compete with 17β-estradiol much stronger than with 5α-dihydrotestosterone for binding to sex hormone-binding globulin.

Plasma Androgens, 17β-estradiol, and sex hormone-binding globulin in patients with hirsutism and/or clitoromegaly

1981 ◽  
Vol 36 (2) ◽  
pp. 188-193 ◽  
Author(s):  
Rajesh S. Mathur ◽  
Gary Holtz ◽  
Elizabeth R. Baker ◽  
Lucia O. Moody ◽  
Sara C. Landgrebe ◽  
...  
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
17Β Estradiol

Metabolic clearance rate of testosterone in male epileptic patients on anti-convulsant therapy

1991 ◽  
Vol 129 (3) ◽  
pp. 465-468 ◽  
Author(s):  
M. J. Wheeler ◽  
B. K. Toone ◽  
A. Dannatt ◽  
P. B. C. Fenwick ◽  
S. Brown
Keyword(s):  
Clearance Rate ◽  
Patient Population ◽  
Free Testosterone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Testosterone Concentration ◽  
The Mean ◽  
Low Testosterone

ABSTRACT There are several reports which state that male epileptics on anti-convulsant therapy have reduced sexual activity. We and others have shown that, although total testosterone is raised, the free testosterone concentration is reduced in this patient population. This could be a result of an increased metabolic clearance rate (MCR) of testosterone, inadequate secretion of LH to stimulate testosterone synthesis or inappropriately low testosterone production by the Leydig cells. We have examined these possibilities by measuring the MCR of testosterone in 15 male epileptics on anti-convulsant therapy. In this group of patients, the mean LH (9·3±5·9 IU/l) and sex-hormone binding globulin (SHBG) (54·5±22·9 nmol/l) concentrations were significantly greater than those of five normal control subjects (4·7±1·11 IU/l and 26·0 ±7·0 nmol/l respectively). Mean total testosterone concentrations of the two groups were not significantly different but the mean percentage of free testosterone and free testosterone concentration were significantly lower in the patient population (2·06±0·43 vs 2·98±0·27 and 0·56±1·1 vs 0·79±0·7 pmol/l). The MCR of testosterone was significantly lower in the patients (773±322 vs 1354±443 1/day) and showed a positive correlation with the percentage of free testosterone. Therefore, our results suggest that the lowered free testosterone in male epileptics on anti-convulsant therapy is not due to an increased MCR of testosterone. The increased LH concentration suggests primary hypogonadism. This, in turn, could be responsible for low free testosterone levels in the presence of normal testosterone. Journal of Endocrinology (1991) 129, 465–468

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