Repeated electroconvulsive shock has no specific anxiolytic effect but reduces social interaction and exploration in rats

1984 ◽  
Vol 23 (1) ◽  
pp. 95-99 ◽  
Author(s):  
Sandra E. File ◽  
A.R. Green
Keyword(s):  
Social Interaction ◽  
Electroconvulsive Shock ◽  
Anxiolytic Effect

scholarly journals Inhibition of ecto-5′-nucleotidase and adenosine deaminase is able to reverse long-term behavioural effects of early ethanol exposure in zebrafish (Danio rerio)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Aline Haab Lutte ◽  
Julia Huppes Majolo ◽  
Rosane Souza Da Silva
Keyword(s):  
Social Interaction ◽  
Adenosine Deaminase ◽  
Developmental Stages ◽  
Specific Inhibitor ◽  
Anxiolytic Effect ◽  
Conduct Disorders ◽  
Ethanol Exposure ◽  
Gastrula Stage ◽  
Behavioural Effects ◽  
Acute And Chronic Exposure

Abstract The behavioural impacts of prenatal exposure to ethanol include a lower IQ, learning problems, anxiety and conduct disorders. Several components of the neurochemical network could contribute to the long-lasting effects of ethanol embryonic exposure. Adenosine is an important neuromodulator, that has been indicated to be affected by acute and chronic exposure to ethanol. Here, embryos of zebrafish exposed to 1% ethanol during the developmental stages of gastrula/segmentation or pharyngula exhibited anxiolytic effect, increased aggressiveness, and decreased social interaction. The exposure during pharyngula stage was able to affect all behavioural parameters analysed at 3 months-post fertilization (mpf), while the treatment during gastrula stage affected the anxiety and social interaction parameters. The aggressiveness was the only behavioural effect of early ethanol exposure that lasted to 12 mpf. The use of a specific inhibitor of adenosine production, the inhibitor of ecto-5′-nucleotidase (AMPCP/150 mg/kg), and the specific inhibitor of adenosine degradation, the inhibitor of adenosine deaminase, EHNA (100 mg/kg) did not affect the effects over anxiety. However, AMPCP at 3 mpf, but not EHNA, reversed aggressive parameters. AMPCP also recovered the social interaction parameter at 3 mpf in animals treated in both stages, while EHNA recovered this parameter just in those animals treated with ethanol during the gastrula stage. These results suggest that long-lasting behavioural effects of ethanol can be modulated by intervention on ecto-5′-nucleotidase and adenosine deaminase activities.

scholarly journals Vitamin K2 Improves Anxiety and Depression but not Cognition in Rats with Metabolic Syndrome: a Role of Blood Glucose?

Folia Medica ◽  
2016 ◽  
Vol 58 (4) ◽  
pp. 264-272 ◽  
Author(s):  
Silvia M. Gancheva ◽  
Maria D. Zhelyazkova-Savova
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Social Interaction ◽  
Fasting Blood Glucose ◽  
Anxiolytic Effect ◽  
Memory Deficit ◽  
Vitamin K2 ◽  
Anxiety And Depression ◽  
Control Group ◽  
Immobility Time

AbstractBackground:The metabolic syndrome is a socially important disorder of energy utilization and storage, recognized as a factor predisposing to the development of depression, anxiety and cognitive impairment in humans.Aim:In the present study we examined the effects of vitamin K2 on the behavior of rats with metabolic syndrome and looked for relationships with the effects on blood sugar.Materials and methods:Male Wistar rats were divided in four groups: a control group on a regular rat chow, a metabolic syndrome (MS) group fed a high-fat high-fructose diet, a control group treated with vitamin K2 and a MS group treated with vitamin K2. Vitamin K2 was given by gavage. At the end of the study (after 10 weeks) behavioral tests were performed and fasting blood glucose was measured. Anxiety was determined using the social interaction test and depression was assessed by the Porsolt test. Memory effects were estimated by the object recognition test. Correlations between fasting blood glucose and behavioral performance were analyzed.Results:The rats from the MS group had elevated blood glucose. They had anxiety, depression and memory deficit. Vitamin K2 normalized blood glucose, reduced anxiety and depression, but did not improve memory. Time of social interaction (inverse index of anxiety) and memory recognition were negatively correlated with blood glucose in the untreated rats but the immobility time (measure of depression) was not. When vitamin K2-treated rats were added, the correlation of blood glucose with the time of social interaction was kept, but the one with the recognition memory was lost. It might be that the anxiolytic effect of vitamin K2 in this setting is at least partly due to its effects on blood glucose, while the anti-depressant effect is glucose-independent.Conclusion:The present study demonstrated that vitamin K2 prevented the development of anxiety and depression, but did not improve the memory deficit caused by the dietary manipulation in an experimental model of metabolic syndrome. It might be that the anxiolytic effect of vitamin K2 is at least partly due to its effects on blood glucose, while the antidepressant effect is glucose-independent.

Evaluation of the Neurobehavioral Properties of Naringin in Swiss Mice

Drug Research ◽  
2018 ◽  
Vol 68 (08) ◽  
pp. 465-474 ◽  
Author(s):  
Benneth Ben-Azu ◽  
Ekene Nwoke ◽  
Solomon Umukoro ◽  
Adegbuyi Aderibigbe ◽  
Abayomi Ajayi ◽  
...  
Keyword(s):  
Social Interaction ◽  
Forced Swim Test ◽  
Intraperitoneal Administration ◽  
Anxiolytic Effect ◽  
Tail Suspension Test ◽  
Flavonoid Compound ◽  
Behavioral Models ◽  
Enhancing Effect ◽  
Y Maze ◽  
Memory Enhancing

Abstract Objectives This study was carried out to investigate the neurobehavioral properties of naringin, a flavonoid compound formed from naringenin on behavioral models in mice. Method The neurobehavioral property of naringin (2.5, 5 and 10 mg/kg) administered intraperitoneally (i.p.) was assessed on novelty-induced rearing, locomotor behavior using open field test; anxiolytic effect was evaluated using hole-board, light and dark box, and elevated-plus maze paradigms. The anti-depressant-like property was also assessed using forced swim test (FST), tail suspension test (TST) and social interaction test (SIT). The cognitive enhancing effect of naringin was evaluated using Y-maze test. Results Intraperitoneal administration of naringin (2.5 and 5 mg/kg) demonstrated significant (p<0.05) increase in rearing behavior but not the spontaneous motor activity in comparison to control. In the anti-depressant test, naringin (2.5, 5 and 10 mg/kg, i.p.) significantly decreased the duration of immobility in the FST and TST, and increased the % social interaction preference in the SIT relative to controls, suggesting anti-depressant-like and increased social behaviors. Moreover, naringin also exhibited anxiolytic and memory enhancing properties in mice. Conclusion These findings suggest that naringin possesses anti-depressant- and anxiolytic-like activities as well as memory enhancing effect in mice.

scholarly journals Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2694 ◽  
Author(s):  
Lucia Caputo ◽  
Marina Reguilon ◽  
José Mińarro ◽  
Vincenzo De Feo ◽  
Marta Rodriguez-Arias
Keyword(s):  
Social Interaction ◽  
Essential Oil ◽  
Social Stress ◽  
Anxiolytic Effect ◽  
Social Defeat ◽  
Mental Illnesses ◽  
Acute Administration ◽  
Social Avoidance ◽  
Lavandula Angustifolia

Many vegetable extracts, essential oils, and their main constituents are active on the Central Nervous System (CNS). In fact, they have been used as sedatives, hypnotics, or tranquilizers for their activity in treating CNS disorders. In this research, we studied the possible activities of Lavandula angustifolia (LA) essential oil and of its main constituent, linalool, as anti-stress compounds on anxiety and social interaction and their in vitro effects on proteins (pERK and PKA) involved in the transmission of the signal. An acute intraperitoneal injection of linalool (100 mg/kg) and of LA essential oil (200 mg/kg) reduced motor activity without any anxiolytic effect, but significantly increased social interaction. Stressed mice, after being exposed to a social defeat encounter, showed heightened anxiety and social avoidance. Acute administration of LA essential oil blocked stress-induced anxiety, while linalool showed no effects. However, both compounds were capable of reversing social aversion, acting as antidepressant agents. Our results showed that linalool inhibits pERK and PKA expression in the SH-SY5Y cell, but no effect was detected with the LA essential oil. Therefore, the LA essential oil and linalool may be considered as useful alternative tools to the available traditional treatments for social stress-induced mental illnesses.

Anxiolytic effect of paroxetine in the rat social interaction model of anxiety: Comparison with sertraline

1993 ◽  
Vol 3 (3) ◽  
pp. 372
Author(s):  
S. Lightowler ◽  
I.J.R. Williamson ◽  
G.A. Kennett ◽  
I.F. Tulloch
Keyword(s):  
Social Interaction ◽  
Interaction Model ◽  
Anxiolytic Effect

Social epistemic actions

2020 ◽  
Vol 43 ◽  
Author(s):  
Giovanni Pezzulo ◽  
Laura Barca ◽  
Domenico Maisto ◽  
Francesco Donnarumma
Keyword(s):  
Social Interaction ◽  
Joint Action ◽  
Niche Construction ◽  
Cultural Practices ◽  
Learning Processes ◽  
Epistemic Actions ◽  
Target Article ◽  
Online Social Interaction

Abstract We consider the ways humans engage in social epistemic actions, to guide each other's attention, prediction, and learning processes towards salient information, at the timescale of online social interaction and joint action. This parallels the active guidance of other's attention, prediction, and learning processes at the longer timescale of niche construction and cultural practices, as discussed in the target article.

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