Immunohistochemistry and ultrastructure of myoepithelium and modified myoepithelium of the ducts of human major salivary glands: Histogenetic implications for salivary gland tumors

1987 ◽  
Vol 64 (6) ◽  
pp. 703-715 ◽  
Author(s):  
Irving Dardick ◽  
Peter Rippstein ◽  
Linda Skimming ◽  
Marie Boivin ◽  
William R. Parks ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Salivary Gland Tumors ◽  
Major Salivary Glands

Simple mucin-type carbohydrate antigens in major salivary glands.

1994 ◽  
Vol 42 (9) ◽  
pp. 1251-1259 ◽  
Author(s):  
M H Therkildsen ◽  
U Mandel ◽  
J Thorn ◽  
M Christensen ◽  
E Dabelsteen
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Acinar Cells ◽  
Salivary Gland Tumors ◽  
Basal Cells ◽  
T Antigens ◽  
Glycosylation Pattern ◽  
Carbohydrate Antigens ◽  
Major Salivary Glands ◽  
Duct Cells

Simple mucin-type carbohydrate antigens Tn, sialosyl-Tn and T are often markers of neoplastic transformation and have very limited expression in normal tissues. We performed an immunohistological study of simple mucin-type carbohydrate antigens, including H and A variants, with well-defined monoclonal antibodies (MAb) on frozen and paraffin-embedded normal salivary gland tissue from 22 parotid, 14 submandibular, six sublingual, and 13 labial glands to elucidate the simple mucin-type glycosylation pattern in relation to cyto- and histodifferentiation. The investigated carbohydrate structures were predominantly observed in the cell cytoplasm, most often in the supranuclear area, suggesting localization to the Golgi region, whereas ductal contents were unstained. Mucous acinar cells expressed Tn, sialosyl-Tn, and H and A antigens, regardless of glandular location. Serous acinar cells, on the other hand, expressed A, H, and inconstantly sialosyl-T, Tn, and sialosyl-Tn antigens in major salivary glands, whereas serous cells of minor (labial) salivary glands expressed H exclusively, Tn and sialosyl-T antigens inconstantly, but never sialosyl-Tn and A antigens. The difference may be related to a more simple cytodifferentiation of serous cells of minor (labial) salivary glands as compared with major salivary glands. Duct cells in major salivary glands expressed A, H, and inconstantly T, sialosyl-T, and Tn antigens, whereas minor (labial) salivary glands ducts exclusively expressed H, T and sialosyl-T antigens, differences that may be related to dissimilarities in the duct system. Myoepithelial cells and basal cells exclusively expressed T and sialosyl-T antigens, which may prove useful in studies of salivary gland tumors, since these cells are known to play a key role in the histological characteristics of some salivary gland tumors. The results indicate a similar glycosylation pattern in the different major salivary glands, whereas minor (labial) salivary gland differ slightly in serous and duct cells. The limited and exclusive intracellular expression of the immature Tn, sialosyl-Tn, and T antigens indicates that these structures may be of value as markers of salivary gland tumors.

scholarly journals Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Nafise Shamloo ◽  
Alireza Ghanadan ◽  
Fahimeh Sadat Hashemian ◽  
Maedeh Ghorbanpour
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Tumors ◽  
The Body ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Cross Sectional ◽  
Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

scholarly journals Salivary Gland Pathologies

2021 ◽  
pp. 939-973
Author(s):  
Nisheet Anant Agni
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Malignant Tumors ◽  
Inflammatory Conditions ◽  
Major Salivary Glands

AbstractSaliva is responsible for various functions from lubrication to digestion. The saliva is secreted by numerous minor and major salivary glands. These salivary glands are sometimes affected by various local and systemic inflammatory conditions, obstructive pathologies with benign and malignant tumors. This chapter deals with various pathologies of salivary glands and their management.

Human Kallikrein 14 (Klk14) Expression in Salivary Gland Tumors

2010 ◽  
Vol 25 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Nelly N. Hashem ◽  
Thomas W. Mara ◽  
Mohamed Mohamed ◽  
Irene Zhang ◽  
Kevin Fung ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Malignant Tumors ◽  
Expression Profiles ◽  
Staining Technique ◽  
Tumor Stage ◽  
Salivary Gland Tumors ◽  
Immunoperoxidase Staining ◽  
Clinical Parameters ◽  
Ductal Cells

Objective To analyze the expression of human kallikrein 14 (KLK14) in salivary gland tumors. Methods A standard immunoperoxidase staining technique was used to assess the expression profile of KLK14 in normal salivary glands and tumors including pleomorphic adenoma (PA; n=17), adenoid cystic carcinoma (ACC; n=13) and mucoepidermoid carcinoma (MEC; n=9). Tumor stage, grade, patient age and gender, and site of occurrence were recorded. These clinical parameters were correlated with KLK14 levels in malignant tumors. The expression profiles for KLK3, 5, 6, 8 and 13 were also retrieved. Results Normal salivary glands, PA, ACC and MEC showed strong expression of KLK14 in ductal and non-ductal cells. Both PA and ACC showed higher KLK14 levels than normal glands and MEC tissues. There were no statistically significant associations between levels of KLK14 and clinical parameters. Conclusions The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland. KLK14 may be a promising new biomarker in salivary gland tumors.

scholarly journals Pleomorphic Adenoma of Minor Salivary Gland in Buccal Mucosa: an Uncommon Finding

2015 ◽  
Vol 03 (01) ◽  
pp. 047-050
Author(s):  
Gourav Ahuja ◽  
Jaideep Marya ◽  
Poonam Sood
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Buccal Mucosa ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Minor Salivary Glands ◽  
Diverse Range ◽  
Neck Tumors

AbstractSalivary gland tumors account for less than 3% of the head and neck tumors. Among various salivary gland tumors, pleomorphic adenoma is most common and accounts for 60- 70% of the benign tumors of salivary glands. However, the involvement of minor salivary glands of buccal mucosa is extremely uncommon and reported to be 4% only. Salivary glands may present with a diverse range of lesions presenting a challenge to even the most experienced clinician. We report two rare cases of pleomorphic adenoma of minor salivary glands of buccal mucosa in a 45 year old female and 70 years old male respectively. It includes clinical features, diagnosis and treatment of the tumor.

scholarly journals Polymorphous low grade adenocarcinoma of the parotid gland: A case report with cytohistological correlation and its immunohistochemical study

2012 ◽  
Vol 2 (4) ◽  
pp. 331-334
Author(s):  
S Shrestha ◽  
CB Pun ◽  
R Basyal ◽  
T Pathak ◽  
S Bastola ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Malignant Tumor ◽  
Immunohistochemical Study ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Major Salivary Glands

Polymorphous low-grade adenocarcinoma is a rare salivary gland malignant tumor of low aggressiveness, commonly occurring in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. We report a case of polymorphous low grade adenocarcinoma arising from left parotid in a 21-yearold female patient.Journal of Pathology of Nepal (2012) Vol. 2, 331-334DOI: http://dx.doi.org/10.3126/jpn.v2i4.6890

scholarly journals A Juvenile Pleomorphic adenoma of the palate

2021 ◽  
Author(s):  
Bouthaina Hammami ◽  
Mohamed Amine Chaabouni ◽  
Ghada Yousfi ◽  
Omar Walha ◽  
Malek Mnejja ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumors ◽  
Radiological Features

Salivary gland tumors in children are rare, involvement of accessory salivary glands is exceptional. We report a case of pleomorphic adenoma of the palate in a child in order to describe the clinical, radiological features, as well as the management of this rare localization.

scholarly journals THU0259 ULTRASOUND OF MAJOR SALIVARY GLANDS IDENTIFIES PATIENTS WITH MORE COMPLEX SALIVARY GLAND HISTOPATHOLOGY BUT NOT MILDER LESIONS

2019 ◽  
Author(s):  
Chiara Baldini ◽  
Francesco Ferro ◽  
Nicoletta Luciano ◽  
Gianmaria Governato ◽  
Marta Mosca ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Major Salivary Glands

Embryoma (Sialoblastoma) of Salivary Glands

1992 ◽  
Vol 101 (11) ◽  
pp. 958-960 ◽  
Author(s):  
John G. Batsakis ◽  
Robert Frankenthaler
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Perinatal Period ◽  
Salivary Gland Tumors ◽  
Major Salivary Gland

There are four clinicopathologic categories of the exclusively major salivary gland tumors that present in the perinatal period. The two with the smallest representation among the 20 cases reported to date are those with a hamartomalike appearance and those with benign adult equivalents — The pleomorphic and monomorphic adenomas. Five cases have been undifferentiated or basaloid salivary carcinomas. Embryomas (sialoblastomas) are the most numerous. These tumors manifest a histologic phenotype like that of the epithelial anlage of the salivary glands, albeit in an arrested state of differentiation.

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