The occurrence of blood group substances (A, B, H, Le-a, Le-b) in salivary glands and salivary gland tumors. An immunohistochemical investigation

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

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Human Kallikrein 14 (Klk14) Expression in Salivary Gland Tumors

The International Journal of Biological Markers ◽

10.1177/172460081002500105 ◽

2010 ◽

Vol 25 (1) ◽

pp. 32-37 ◽

Cited By ~ 7

Author(s):

Nelly N. Hashem ◽

Thomas W. Mara ◽

Mohamed Mohamed ◽

Irene Zhang ◽

Kevin Fung ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Malignant Tumors ◽

Expression Profiles ◽

Staining Technique ◽

Tumor Stage ◽

Salivary Gland Tumors ◽

Immunoperoxidase Staining ◽

Clinical Parameters ◽

Ductal Cells

Objective To analyze the expression of human kallikrein 14 (KLK14) in salivary gland tumors. Methods A standard immunoperoxidase staining technique was used to assess the expression profile of KLK14 in normal salivary glands and tumors including pleomorphic adenoma (PA; n=17), adenoid cystic carcinoma (ACC; n=13) and mucoepidermoid carcinoma (MEC; n=9). Tumor stage, grade, patient age and gender, and site of occurrence were recorded. These clinical parameters were correlated with KLK14 levels in malignant tumors. The expression profiles for KLK3, 5, 6, 8 and 13 were also retrieved. Results Normal salivary glands, PA, ACC and MEC showed strong expression of KLK14 in ductal and non-ductal cells. Both PA and ACC showed higher KLK14 levels than normal glands and MEC tissues. There were no statistically significant associations between levels of KLK14 and clinical parameters. Conclusions The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland. KLK14 may be a promising new biomarker in salivary gland tumors.

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Pleomorphic Adenoma of Minor Salivary Gland in Buccal Mucosa: an Uncommon Finding

Dental Journal of Advance Studies ◽

10.1055/s-0038-1672013 ◽

2015 ◽

Vol 03 (01) ◽

pp. 047-050

Author(s):

Gourav Ahuja ◽

Jaideep Marya ◽

Poonam Sood

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Buccal Mucosa ◽

Minor Salivary Gland ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Minor Salivary Glands ◽

Diverse Range ◽

Neck Tumors

AbstractSalivary gland tumors account for less than 3% of the head and neck tumors. Among various salivary gland tumors, pleomorphic adenoma is most common and accounts for 60- 70% of the benign tumors of salivary glands. However, the involvement of minor salivary glands of buccal mucosa is extremely uncommon and reported to be 4% only. Salivary glands may present with a diverse range of lesions presenting a challenge to even the most experienced clinician. We report two rare cases of pleomorphic adenoma of minor salivary glands of buccal mucosa in a 45 year old female and 70 years old male respectively. It includes clinical features, diagnosis and treatment of the tumor.

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Simple mucin-type carbohydrate antigens in major salivary glands.

Journal of Histochemistry & Cytochemistry ◽

10.1177/42.9.8064132 ◽

1994 ◽

Vol 42 (9) ◽

pp. 1251-1259 ◽

Cited By ~ 13

Author(s):

M H Therkildsen ◽

U Mandel ◽

J Thorn ◽

M Christensen ◽

E Dabelsteen

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Acinar Cells ◽

Salivary Gland Tumors ◽

Basal Cells ◽

T Antigens ◽

Glycosylation Pattern ◽

Carbohydrate Antigens ◽

Major Salivary Glands ◽

Duct Cells

Simple mucin-type carbohydrate antigens Tn, sialosyl-Tn and T are often markers of neoplastic transformation and have very limited expression in normal tissues. We performed an immunohistological study of simple mucin-type carbohydrate antigens, including H and A variants, with well-defined monoclonal antibodies (MAb) on frozen and paraffin-embedded normal salivary gland tissue from 22 parotid, 14 submandibular, six sublingual, and 13 labial glands to elucidate the simple mucin-type glycosylation pattern in relation to cyto- and histodifferentiation. The investigated carbohydrate structures were predominantly observed in the cell cytoplasm, most often in the supranuclear area, suggesting localization to the Golgi region, whereas ductal contents were unstained. Mucous acinar cells expressed Tn, sialosyl-Tn, and H and A antigens, regardless of glandular location. Serous acinar cells, on the other hand, expressed A, H, and inconstantly sialosyl-T, Tn, and sialosyl-Tn antigens in major salivary glands, whereas serous cells of minor (labial) salivary glands expressed H exclusively, Tn and sialosyl-T antigens inconstantly, but never sialosyl-Tn and A antigens. The difference may be related to a more simple cytodifferentiation of serous cells of minor (labial) salivary glands as compared with major salivary glands. Duct cells in major salivary glands expressed A, H, and inconstantly T, sialosyl-T, and Tn antigens, whereas minor (labial) salivary glands ducts exclusively expressed H, T and sialosyl-T antigens, differences that may be related to dissimilarities in the duct system. Myoepithelial cells and basal cells exclusively expressed T and sialosyl-T antigens, which may prove useful in studies of salivary gland tumors, since these cells are known to play a key role in the histological characteristics of some salivary gland tumors. The results indicate a similar glycosylation pattern in the different major salivary glands, whereas minor (labial) salivary gland differ slightly in serous and duct cells. The limited and exclusive intracellular expression of the immature Tn, sialosyl-Tn, and T antigens indicates that these structures may be of value as markers of salivary gland tumors.

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A Juvenile Pleomorphic adenoma of the palate

10.22541/au.163290086.68531948/v1 ◽

2021 ◽

Author(s):

Bouthaina Hammami ◽

Mohamed Amine Chaabouni ◽

Ghada Yousfi ◽

Omar Walha ◽

Malek Mnejja ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Salivary Gland Tumors ◽

Radiological Features

Salivary gland tumors in children are rare, involvement of accessory salivary glands is exceptional. We report a case of pleomorphic adenoma of the palate in a child in order to describe the clinical, radiological features, as well as the management of this rare localization.

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Embryoma (Sialoblastoma) of Salivary Glands

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949210101115 ◽

1992 ◽

Vol 101 (11) ◽

pp. 958-960 ◽

Cited By ~ 37

Author(s):

John G. Batsakis ◽

Robert Frankenthaler

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Perinatal Period ◽

Salivary Gland Tumors ◽

Major Salivary Gland

There are four clinicopathologic categories of the exclusively major salivary gland tumors that present in the perinatal period. The two with the smallest representation among the 20 cases reported to date are those with a hamartomalike appearance and those with benign adult equivalents — The pleomorphic and monomorphic adenomas. Five cases have been undifferentiated or basaloid salivary carcinomas. Embryomas (sialoblastomas) are the most numerous. These tumors manifest a histologic phenotype like that of the epithelial anlage of the salivary glands, albeit in an arrested state of differentiation.

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Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors

Acta Médica Portuguesa ◽

10.20344/amp.9023 ◽

2018 ◽

Vol 31 (11) ◽

pp. 641 ◽

Cited By ~ 2

Author(s):

Jorge Pinheiro ◽

Margarida Sá Fernandes ◽

Ana Rodrigues Pereira ◽

José Manuel Lopes

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Survival Rates ◽

Disease Free Survival ◽

Salivary Gland Tumors ◽

Histological Subtypes ◽

Free Survival ◽

Clinical Behavior ◽

Epithelial Tumors ◽

Disease Free

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.Material and Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Disease-free survival and overall survival were evaluated using Kaplan-Meier survival curves and compared using the Mantel-Cox log-rank test. The significance threshold was set at 0.05.Results: We selected 295 cases, 150 males with a mean age at diagnosis of 50.4 (± 16.4) years. Primary benign epithelial tumors [n = 228 (77.3%)] were mostly pleomorphic adenomas [n = 148 (64.9%)] and Warthin tumors [n = 61 (26.8%)]. Primary malignant epithelial tumors [n = 43 (14.8%)] included mucoepidermoid [n = 16 (37.2%)], adenoid cystic [n = 6 (14.0%)] and acinic cell [n = 5 (11.6%)] carcinomas; 32 (74.4%) in parotid, 2 (4.6%) in submandibular and 9 (21%) in minor salivary glands. Primary epithelial tumors were more frequently malignant in minor (33.3%) than in major (13.9%) salivary glands. Local recurrence occurred in 30.2% and distant metastases in 25.6% tumors. The mean disease-free interval was 26 (± 37.5) months; most metastases were in lung and central nervous system. The 5 and 10 year disease-free survival rates were 63.4% and 50.1%, respectively; the 5 and 10 year disease-specific survival rates were 76.9% and 57.9%, respectively. Primary salivary tumors included also lymphomas [n = 8 (2.7%)] and soft tissue tumors [n = 5 (1.7%)]. Secondary tumors included metastases of carcinomas [n = 7 (2.4%)] and involvement by lymphoma [n = 1 (0.3%)].Discussion: Our results concerning age, gender, histological subtype, frequency and clinical behavior of salivary tumors concur with European studies. Divergence with Portuguese studies might be related with the inclusion criteria, clinical referral and time lag variations.Conclusion: Although uncommon, salivary gland tumors occur in a wide age range and include histological subtypes with diverse prognosis.

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