Embryoma (Sialoblastoma) of Salivary Glands

There are four clinicopathologic categories of the exclusively major salivary gland tumors that present in the perinatal period. The two with the smallest representation among the 20 cases reported to date are those with a hamartomalike appearance and those with benign adult equivalents — The pleomorphic and monomorphic adenomas. Five cases have been undifferentiated or basaloid salivary carcinomas. Embryomas (sialoblastomas) are the most numerous. These tumors manifest a histologic phenotype like that of the epithelial anlage of the salivary glands, albeit in an arrested state of differentiation.

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Clinical and own experience in the treatment of major salivary gland tumors

Otolaryngologia Polska ◽

10.5604/01.3001.0013.6605 ◽

2020 ◽

Vol 74 (2) ◽

pp. 1-5

Author(s):

Anna Jałocha-Kaczka ◽

Katarzyna Kolary-Siekierska ◽

Jarosław Miłoński ◽

Jurek Olszewski

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Malignant Tumors ◽

Salivary Gland Tumors ◽

Major Salivary Gland ◽

Tubular Adenoma ◽

Benign Neoplasms ◽

Warthin Tumor ◽

Superficial Lobe ◽

Extracapsular Dissection

Introduction: The paper aims to demonstrate the Clinic’s and own research in the treatment of major salivary gland tumors. Material and method: In the years 2013–2019, there were 95 salivary gland surgeries, including 45 performed in women (47.36%) aged between 24 and 82 and in 50 men (52.64%) aged 29 to 86. Diagnostics of major salivary glands included: patient history, otolaryngological examination, ultrasound and fine needle aspiration (BACC) (of tumor), laboratory tests (morphology, CRP) and computed tomography (CT) or magnetic resonance imaging (MRI) to accurately assess salivary glands, location of lesion and lymph nodes prior to elective surgery. Research results: In the analyzed material patients with major salivary gland tumors were most frequently operated on at the age of 61–70 (34.7%) and 51–60 years (23.2%). Most patients with tumors were hospitalized in the last 4 years between 2016–2019, which accounted for 77.8% of all operated cases. Among the operated lesions, benign neoplasms and tumors occurred in 93.7%, of which the most frequent findings in histopathological examination were Warthin tumor in 50.5%, and multiform adenoma in 26.3%. The remaining tumors and benign neoplasms constituted only 16.9% and were observed in isolated cases, including eosinophilic adenoma, lymphoepithelial cyst, myoepithelial adenoma, lipofibrosarcoma, congestive cyst, air cyst, tubular adenoma, basal cell carcinoma, cyst with squamous metaplasia features, vascular malformation. Malignant salivary gland tumors were found in 6.3%, including the following malignant tumors were revealed histopathologically: adenocarcinoma, mucoepidermal carcinoma, acinocellular carcinoma, epithelialmyoepithelial carcinoma, ductal carcinoma. Conclusions: The majority of operated salivary gland tumors were benign (93.7%), of which the most common histopathologically were: Warthin tumor (50.5%) and multiform adenoma (26.3%), while malignant tumors occurred in 6.3%. Tumors were localized mainly in the parotid gland in as many as 93.7% cases, of which the most common localization concerned the superficial lobe in 56.8%. The most frequent surgical technique used in the Clinic was extracapsular dissection of the tumor in 88.4%, and other methods were used rarely.

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PO-0804: Adjuvant radiotherapy in the management of major salivary gland tumors – Retrospective analysis

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)00821-5 ◽

2020 ◽

Vol 152 ◽

pp. S436

Author(s):

A. Florindo ◽

S. Saraiva ◽

T.C. Tomás ◽

A. Abrunhosa-Branquinho ◽

V. Mendonça ◽

...

Keyword(s):

Salivary Gland ◽

Retrospective Analysis ◽

Adjuvant Radiotherapy ◽

Salivary Gland Tumors ◽

Major Salivary Gland

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Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy

Head & Neck ◽

10.1002/hed.26563 ◽

2021 ◽

Vol 43 (4) ◽

pp. 1056-1062

Author(s):

Kaveh Zakeri ◽

Huili Wang ◽

Jung Julie Kang ◽

Anna Lee ◽

Paul Romesser ◽

...

Keyword(s):

Radiation Therapy ◽

Salivary Gland ◽

Prognostic Factors ◽

Proton Beam ◽

Salivary Gland Tumors ◽

Major Salivary Gland ◽

Beam Radiation ◽

Proton Beam Radiation ◽

Proton Beam Radiation Therapy

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MAJOR SALIVARY GLAND TUMORS

The Laryngoscope ◽

10.1288/00005537-198610000-00014 ◽

1986 ◽

Vol 96 (10) ◽

pp. 1139???1144 ◽

Cited By ~ 44

Author(s):

LUU TRAN ◽

AHMAD SADEGHI ◽

GUY JUILLARD ◽

THOMAS C. CALCATERRA ◽

DAVID HANSON ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Gland Tumors ◽

Major Salivary Gland

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Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

Shiraz E-Medical Journal ◽

10.5812/semj.107675 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Nafise Shamloo ◽

Alireza Ghanadan ◽

Fahimeh Sadat Hashemian ◽

Maedeh Ghorbanpour

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Malignant Tumors ◽

The Body ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Cross Sectional ◽

Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

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The occurrence of blood group substances (A, B, H, Le-a, Le-b) in salivary glands and salivary gland tumors. An immunohistochemical investigation

Journal of Oral Pathology and Medicine ◽

10.1111/j.1600-0714.1986.tb00635.x ◽

1986 ◽

Vol 15 (6) ◽

pp. 334-338 ◽

Cited By ~ 9

Author(s):

K. Hamper ◽

J. Caselitz ◽

G. Seifert ◽

R. Seitz ◽

A. Poschmann

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Blood Group ◽

Salivary Gland Tumors ◽

Immunohistochemical Investigation ◽

Blood Group Substances

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Pattern of distribution of different salivary gland tumors; a retrospective study in NICRH, Dhaka

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v15i1.27148 ◽

2016 ◽

Vol 15 (1) ◽

pp. 95-98

Author(s):

Afroza Khanam ◽

Gulshan Akhter ◽

Md. Abdur Rahman

Keyword(s):

Salivary Gland ◽

Retrospective Study ◽

Parotid Gland ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Salivary Gland Tumors ◽

Major Salivary Gland ◽

Gland Tumor ◽

Minor Salivary Gland Tumors ◽

Malignant Salivary Gland Tumors

Background: Salivary gland tumors are rare, generally benign and affect both major and minor salivary glands.Objective: To find out the pattern of distribution of different benign and malignant salivary gland epithelial tumors and their relation to age and sex in a tertiary care center in Bangladesh.Methodology: This is a retrospective study. Details of epithelial salivary gland tumors were obtained from department of ENT, National institute of cancer & research hospital (NICRH), Dhaka, Bangladesh from the period January 2009 to December 2012 (3 years).Result: A total number of 261 cases presenting with both benign and malignant salivary gland tumors were analyzed according to gender, age and histopathological findings. There were 130 (49.84%) males and 131 (50.19%) females with the male female ration of 1: 0.99. Age of study population ranged from 10 to 70 years with the mean age 40.78. Percentage of benign salivary gland tumors was 73.94% and malignant salivary gland tumor 26.05%. Among major salivary gland tumors, no sublingual tumors were found and parotid gland tumors were the commonest. Whereas, among minor salivary gland tumors palatal minor salivary tumors were common.Conclusion: Parotid gland was the most common site of origin of both benign and malignant salivary gland tumors. Histopathologically, pleomorphic adenoma was the most common benign salivary gland tumor and mucoepidermoid carcinoma was the most frequent malignant neoplasm. Adenoid cystic carcinoma was common minor salivary gland tumor.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.90-94

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Human Kallikrein 14 (Klk14) Expression in Salivary Gland Tumors

The International Journal of Biological Markers ◽

10.1177/172460081002500105 ◽

2010 ◽

Vol 25 (1) ◽

pp. 32-37 ◽

Cited By ~ 7

Author(s):

Nelly N. Hashem ◽

Thomas W. Mara ◽

Mohamed Mohamed ◽

Irene Zhang ◽

Kevin Fung ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Malignant Tumors ◽

Expression Profiles ◽

Staining Technique ◽

Tumor Stage ◽

Salivary Gland Tumors ◽

Immunoperoxidase Staining ◽

Clinical Parameters ◽

Ductal Cells

Objective To analyze the expression of human kallikrein 14 (KLK14) in salivary gland tumors. Methods A standard immunoperoxidase staining technique was used to assess the expression profile of KLK14 in normal salivary glands and tumors including pleomorphic adenoma (PA; n=17), adenoid cystic carcinoma (ACC; n=13) and mucoepidermoid carcinoma (MEC; n=9). Tumor stage, grade, patient age and gender, and site of occurrence were recorded. These clinical parameters were correlated with KLK14 levels in malignant tumors. The expression profiles for KLK3, 5, 6, 8 and 13 were also retrieved. Results Normal salivary glands, PA, ACC and MEC showed strong expression of KLK14 in ductal and non-ductal cells. Both PA and ACC showed higher KLK14 levels than normal glands and MEC tissues. There were no statistically significant associations between levels of KLK14 and clinical parameters. Conclusions The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland. KLK14 may be a promising new biomarker in salivary gland tumors.

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