Vascular changes in the dental pulp in the hypercholesterolemic miniature swine

1992 ◽  
Vol 74 (3) ◽  
pp. 351-356 ◽  
Author(s):  
Bamiduro R. Oguntebi ◽  
Douglas S. Stafford ◽  
James Cerda ◽  
Frank Robbins
Keyword(s):  
Dental Pulp ◽  
Vascular Changes ◽  
Miniature Swine

scholarly journals Expression and Function of Hypoxia Inducible Factor-1αand Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Fulan Wei ◽  
Shuangyan Yang ◽  
Hui Xu ◽  
Qingyuan Guo ◽  
Qi Li ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Tooth Movement ◽  
Mechanical Load ◽  
Cell Damage ◽  
Orthodontic Tooth Movement ◽  
Mechanical Force ◽  
Vascular Changes ◽  
Pulp Tissue ◽  
Defensive Reaction ◽  
Orthodontic Force

Orthodontic force may lead to cell damage, circulatory disturbances, and vascular changes of the dental pulp, which make a hypoxic environment in pulp. In order to maintain the homeostasis of dental pulp, hypoxia will inevitably induce the defensive reaction. However, this is a complex process and is regulated by numerous factors. In this study, we established an experimental animal model of orthodontic tooth movement to investigate the effects of mechanical force on the expression of VEGF and HIF-1αin dental pulp. Histological analysis of dental pulp and expressions of HIF-1αand VEGF proteins in dental pulp were examined. The results showed that inflammation and vascular changes happened in dental pulp tissue in different periods. Additionally, there were significant changes in the expression of HIF-1αand VEGF proteins under orthodontic force. After application of mechanical load, expression of HIF-1αand VEGF was markedly positive in 1, 3, 7 d, and 2 w groups, and then it weakened in 4 w group. These findings suggested that the expression of HIF-1αand VEGF was enhanced by mechanical force. HIF-1αand VEGF may play an important role in retaining the homeostasis of dental pulp during orthodontic tooth movement.

scholarly journals A Miniature Swine Model for Stem Cell-Based De Novo Regeneration of Dental Pulp and Dentin-Like Tissue

2018 ◽  
Vol 24 (2) ◽  
pp. 108-120 ◽  
Author(s):  
Xiaofei Zhu ◽  
Jie Liu ◽  
Zongdong Yu ◽  
Chao-An Chen ◽  
Hacer Aksel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dental Pulp ◽  
De Novo ◽  
Swine Model ◽  
Miniature Swine

An electron microscopic study of the intra-myocardial lesions in cases of acute myocardial infarction

1978 ◽  
Vol 36 (2) ◽  
pp. 484-485
Author(s):  
Masahiro Ono ◽  
Kaoru Aihara ◽  
Gompachi Yajima
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Vessels ◽  
Vascular Wall ◽  
Vascular Changes ◽  
Electron Microscopic ◽  
Main Trunk ◽  
Mechanical Destruction ◽  
Transmission Electron ◽  
Myocardial Lesions

The pathogenesis of the arteriosclerosis in the acute myocardial infarction is the matter of the extensive survey with the transmission electron microscopy in experimental and clinical materials. In the previous communication,the authors have clarified that the two types of the coronary vascular changes could exist. The first category is the case in which we had failed to observe no occlusive changes of the coronary vessels which eventually form the myocardial infarction. The next category is the case in which occlusive -thrombotic changes are observed in which the myocardial infarction will be taken placed as the final event. The authors incline to designate the former category as the non-occlusive-non thrombotic lesions. The most important findings in both cases are the “mechanical destruction of the vascular wall and imbibition of the serous component” which are most frequently observed at the proximal portion of the coronary main trunk.

Detection and Assessment of Interleukin 6 in Irreversible Pulp Inflamation

2017 ◽  
Vol 68 (2) ◽  
pp. 323-327
Author(s):  
Cristian Levente Giuroiu ◽  
Maria Vataman ◽  
Gabriel Melian ◽  
Dragos Bularda ◽  
Ludmila Lozneanu ◽  
...  
Keyword(s):  
Dental Caries ◽  
Interleukin 6 ◽  
Dental Pulp ◽  
The Other ◽  
Control Group ◽  
Study Group ◽  
Pulp Tissue ◽  
Immunohistochemical Technique ◽  
Systemic Distribution ◽  
Cell Zone

The study aimed to assess the number, localization and distribution of interleukin 6 (IL-6) positive cells in healthy pulp, acute and chronic pulpitis. The study group included 48 patients aged between 18-72, treated in University of Medicine and Pharmacy Grigore T. Popa Iasi, Romania. The pulpectomy was performed on 42 patients diagnosed with acute and chronic pulpitis. The other 6 patients, without signs of dental caries or periodontal disease, were submitted to extractions of teeth for orthodontic purposes, with pulpectomy performed before extraction. The pulp samples were examined with optic microscope. The detection and assessment of IL-6 were performed using immunohistochemical technique. Data were statistically analysed using non-parametric tests. According to morphopathological criteria, 42.85% were classified as acute pulpitis and 57.14% as chronic pulpitis. The pulp samples in control group were not associated with IL-6 positive cells. The analysis of all samples with acute and chronic pulpitis identified 73.80% samples with IL-6 and 26.20% associated with the absence of IL-6. The highest frequency of IL-6 positive cells was recorded in rich-cell zone of crown dental pulp. The systemic distribution of IL-6 positive cells was mostly diffused without well-defined orientation. IL-6 release in acute and chronic pulpitis is significantly higher comparing with healthy pulp tissue.

Tranylcypromine Attenuates Senescence in Dental Pulp Stem Cells

2017 ◽  
Vol 14 (7) ◽  
Author(s):  
Junjun Liu ◽  
Zhi Liu ◽  
Chunyan Wang ◽  
Fang Yu ◽  
Wenping Cai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells
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