Isolation of virus-like particles associated with Kilham rat virus infection of tissue cultures

Virus-like particles have been shown to be present in all strains of Penicillium chrysogenum examined but not in penicillin producing strains of P. notatum. Attempts to "cure" P. chrysogenum of the virus infection were not successful, nor was it possible to infect P. notatum with the purified virus from P. chrysogenum. Examination of longitudinal sections of the mycelia of P. chrysogenum showed that the virus particles are enclosed in vesicles in the infected cells.

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Ebola virus-like particles protect from lethal Ebola virus infection

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.2237038100 ◽

2003 ◽

Vol 100 (26) ◽

pp. 15889-15894 ◽

Cited By ~ 178

Author(s):

K. L. Warfield ◽

C. M. Bosio ◽

B. C. Welcher ◽

E. M. Deal ◽

M. Mohamadzadeh ◽

...

Keyword(s):

Virus Infection ◽

Ebola Virus ◽

Virus Like Particles ◽

Ebola Virus Infection

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Neuraminidase-based recombinant virus-like particles protect against lethal avian influenza A(H5N1) virus infection in ferrets

Virology ◽

10.1016/j.virol.2017.06.006 ◽

2017 ◽

Vol 509 ◽

pp. 90-97 ◽

Cited By ~ 17

Author(s):

Gale E. Smith ◽

Xiangjie Sun ◽

Yaohui Bai ◽

Ye V. Liu ◽

Michael J. Massare ◽

...

Keyword(s):

Virus Infection ◽

Avian Influenza ◽

Recombinant Virus ◽

Influenza A ◽

H5n1 Virus ◽

Virus Like Particles

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The use of Bayesian methods for evaluating the performance of a virus-like particles-based ELISA for serology of hepatitis E virus infection in swine

Journal of Virological Methods ◽

10.1016/j.jviromet.2009.10.019 ◽

2010 ◽

Vol 163 (2) ◽

pp. 329-335 ◽

Cited By ~ 18

Author(s):

Nicolas Rose ◽

Annie Boutrouille ◽

Christelle Fablet ◽

François Madec ◽

Marc Eloit ◽

...

Keyword(s):

Virus Infection ◽

Bayesian Methods ◽

Hepatitis E Virus ◽

Hepatitis E ◽

Virus Like Particles

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Faculty Opinions recommendation of TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023712.281689 ◽

2005 ◽

Author(s):

Matthias von Herrath

Keyword(s):

Virus Infection ◽

Kilham Rat Virus

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Bluetongue virus serotype 8 virus-like particles protect sheep against virulent virus infection as a single or multi-serotype cocktail immunogen

Vaccine ◽

10.1016/j.vaccine.2012.11.016 ◽

2013 ◽

Vol 31 (3) ◽

pp. 553-558 ◽

Cited By ~ 23

Author(s):

Meredith Stewart ◽

Eric Dubois ◽

Corinne Sailleau ◽

Emmanuel Bréard ◽

Cyril Viarouge ◽

...

Keyword(s):

Virus Infection ◽

Bluetongue Virus ◽

Virus Like Particles ◽

Virus Serotype ◽

Virulent Virus

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Secondary infection of rat lungs with Pasteurella pneumotropica after Kilham rat virus infection

Laboratory Animals ◽

10.1258/002367781780893777 ◽

1981 ◽

Vol 15 (3) ◽

pp. 219-221 ◽

Cited By ~ 9

Author(s):

P. Carthew ◽

J. Gannon

Keyword(s):

Virus Infection ◽

Respiratory Disease ◽

Experimental Infection ◽

Bacterial Colonization ◽

Secondary Infection ◽

Rat Lungs ◽

Primary Damage ◽

Kilham Rat Virus

Lung congestion was observed after an outbreak of Kilham rat virus infection (KRV) in a rat colony, previously free of all rat viruses. A high proportion of congested lungs contained Pasteurella pneumotropica suggesting that KRV might have caused primary damage to the alveoli (hitherto not recorded) which allowed the secondary bacterial colonization. Experimental infection of rats with KRV caused acute damage to the lung alveoli. Since KRV infection is very common in animal facilities it could therefore be a significant agent in the development of respiratory disease.

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