Food additives on acceptable daily intake (ADI) level affect the agonist induced platelet activation I. Antioxidants and preservatives

Chemosphere ◽  
1994 ◽  
Vol 29 (6) ◽  
pp. 1293-1299
Author(s):  
Hiroyasu Yamazaki ◽  
Takako Yamaguchi ◽  
Aiko Yamauchi ◽  
Yasuo Kakiuchi
Keyword(s):  
Platelet Activation ◽  
Food Additives ◽  
Daily Intake ◽  
Acceptable Daily Intake

Conditions for Use of Food Additives Based on a Budget for an Acceptable Daily Intake1

1979 ◽  
Vol 42 (5) ◽  
pp. 429-434 ◽  
Author(s):  
SØREN C. HANSEN
Keyword(s):  
Body Weight ◽  
Food Additives ◽  
Daily Intake ◽  
Common Market ◽  
Regulatory Agencies ◽  
Acceptable Daily Intake ◽  
Quantitative Expression ◽  
Total Intake ◽  
The Difference ◽  
Food And Drink

Use of food additives is regulated qualitatively in the European Common Market through the EEC directives on food additives, while the concept of Acceptable Daily Intake (ADI) provides a quantitative expression of safe amounts for the guidance of regulatory agencies. It is suggested that a permissible quantity or quantities, the ceiling, should be agreed upon for each permitted additive on the basis of its ADI and in accordance with the procedure described here. The estimation of intake of food and drink starts from the child, who on the basis of body weight has the highest consumption. When dealing with total intake (expressed as energy, weight or volume per kg body weight per day), occupational and climatical variations between adults are largely contained in the difference between child and adult. It is possible to calculate the highest concentration in foodstuffs which is consistent with the ADI, under the assumption that the additive occurs evenly distributed in the whole diet of a child. This concentration is called the primary ceiling. To obtain the technological effect, however, higher concentrations may be needed, and to accomodate this the ceiling may have to be raised. This can be done if the use of the additive can be excluded from or reserved for part of the diet.

scholarly journals Jurnal_TEDC Vol. 10 No. 3 September 2016

2019 ◽  
Author(s):  
Lusi Marlina
Keyword(s):  
Body Weight ◽  
Chemical Engineering ◽  
Food Additives ◽  
Daily Intake ◽  
Gravimetric Method ◽  
Artificial Sweeteners ◽  
Artificial Sweetener ◽  
Acceptable Daily Intake ◽  
Constant Weight ◽  
Fixed Constant

IDENTIFIKASI KANDUNGAN SIKLAMAT PADA MINUMANYANG DIJUAL DI PINGGIR JALAN CIHAMPELASSAMPAI JALAN BATUJAJARLusi Marlina*, Annisa Rani Sa’adah**Program Studi Teknik Kimia, Politeknik TEDC BandungJalan Pasantren Km 2 Cibabat Cimahi Utara 40513Email: [email protected] buatan adalah bahan tambahan makanan yang ditambahkan dalam makanan atau minuman untukmenciptakan rasa manis. Siklamat merupakan jenis pemanis buatan yang memiliki kemanisan 30 kali lebihmanis dari pada sukrosa. Pemakaian pemanis sintetis masih diragukan keamanannya bagi kesehatankonsumen, Beberapa negara mengeluarkan peraturan secara ketat atau bahkan melarang penggunaannya,seperti kanada sejak 1977. Batas Maksimum Penggunaan Siklamat yang diatur dalam ADI (acceptable dailyintake) atau kebutuhan per orang per hari adalah sebanyak 0 – 11 mg per berat badan per hari. Sementarakadar maksimum siklamat dalam minuman 3 gr/L. Untuk mengidentifikasi kandungan siklamat pada minumandapat menggunakan metode gravimetri. metode gravimetri adalah cara analisis kuantitatif berdasarkan berattetap (berat konstannya). Penelitian ini bertujuan untuk mengidentifikasi kandungan siklamat pada minumanyang dijual di pinggir jalan. Dengan mengambil 6 sampel minuman. Pengujian dilakukan di laboratoriumteknik kimia Politeknik TEDC Bandung. Berdasarkan hasil penelitian secara kuantitatif dari 6 sampel seluruhsampel terdeteksi mengandung siklamat, dengan kadar terendah 3 mg dan kadar tertinggi 14,3 mg.Kata kunci: Minuman jajanan, Pemanis Buatan, Siklamat.AbstractAn artificial sweeteners are the food additives that are added to foods or beverages to create a sweet taste.Cyclamate is a kind of artificial sweetener that has a sweetness 30 times sweeter than sucrose. The use ofartificial sweeteners is still questionable safety for the health of consumers, some countries issue regulationsstrictly or even prohibit its use, such as Canada since 1977. Limit Use of Cyclamates set out in the ADI(acceptable daily intake) or requirement per person per day is as much as 0-11 mg per body weight per day.While the maximum levels of cyclamate in drinks 3 g / L. To identify the content of cyclamate in beveragescan using gravimetric methods. gravimetric method is a method of quantitative analysis based on the weightof fixed (constant weight). This study aims to identify the content of cyclamate in drinks sold on the roadside.By taking 6 samples drinks. Tests conducted in the laboratory of chemical engineering TEDC PolytechnicBandung. Based on the results of a quantitative study of 6 samples throughout the sample is detected tocontain cyclamate, with the lowest levels of 3 mg and the highest levels of 14.3 mg.Keywords: Hawker food, An artificial sweeteners, cyclamate

scholarly journals Intake of Non-Nutritive Sweeteners in Chilean Children after Enforcement of a New Food Labeling Law that Regulates Added Sugar Content in Processed Foods

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1594
Author(s):  
Ximena Martínez ◽  
Yazmín Zapata ◽  
Victoria Pinto ◽  
Camila Cornejo ◽  
Martje Elbers ◽  
...  
Keyword(s):  
Sugar Content ◽  
Food Additives ◽  
Daily Intake ◽  
Food Labeling ◽  
Processed Foods ◽  
Acceptable Daily Intake ◽  
Added Sugar ◽  
Food Frequency ◽  
Consumption Frequency ◽  
Wide Range

After enforcement of a new food labeling law in 2016, Chile exhibits a greater offer to reduced sugar products with addition of non-nutritive sweeteners (NNS). Many of these products are consumed by children, who are at greater risk of reaching the acceptable daily intake (ADI) of these food additives. The objective of this study was to evaluate the intake levels of NNS in Chilean schoolchildren after the enactment of the aforementioned law. A total of 250 Chilean children 6–12 years old were surveyed. NNS intake was assessed through a food frequency questionnaire. All children evaluated consumed at least one NNS during the previous month. Sucralose had the highest consumption frequency reaching 99.2%, followed by acesulfame-K (92.8%), stevia (86.0%), and aspartame (85.2%). Aspartame showed the highest median intake, which came mainly from beverages (96%). No children exceeded the ADI of any NNS. Smaller children exhibited a higher body weight-adjusted intake of sucralose, acesulfame-K, stevia, and aspartame (p < 0.05). In Chile, a wide range of processed foods with NNSs is available and all schoolchildren evaluated consumed at least one product containing NNS. However, this consumption does not exceed defined ADIs for any of the six sweeteners authorized for food use in Chile.

scholarly journals Toxicological and ecotoxicological aspects of tartrazine yellow food dye: a literature review

2020 ◽  
Vol 56 (1) ◽  
pp. 137-151
Author(s):  
Janete da Silva ◽  
Renata Fracacio
Keyword(s):  
Food Additives ◽  
Daily Intake ◽  
Toxic Effects ◽  
Human Consumption ◽  
Expert Committee ◽  
Acceptable Daily Intake ◽  
Aquatic Life ◽  
Food Dye ◽  
Ecotoxicological Effect ◽  
Industry And Commerce

The use of the tartrazine yellow additive in food products for human consumption is permitted within the acceptable daily intake of 7.5 mg/kg of body weight per day (following the Joint Expert Committee on Food Additives standards). However, studies have described this as a toxic compo-nent. The dye, which is intensively used in the industry and commerce, enters the aquatic environ-ment through releases of non-treated or inadequately treated effluents; however, further ecotoxico-logical research is needed. We addressed studies reporting the toxic effects of the exposure to this dye developed in humans, guinea pigs, and Danio rerio (a fish with molecular bases and genomes similar to humans). Based on this review, the doses allowed for acceptable daily intake, or even lower, toxic effects, can be evidenced for different organisms, life stages, and tested times. The re-ported values may not be protective to aquatic life. In a paper about the exposure of D. rerio from embryos to larvae kept at values lower than 0.05 and 0.5 g.L-1 for pure and commercial tartrazine, there was ecotoxicological effect for embryos and larvae 48 hours after hatching, which implied cardiac edema, changes in the yolk sac, scoliosis, and tail distortions.

The application of in vitro data in the derivation of the Acceptable Daily Intake of food additives

1999 ◽  
Vol 37 (12) ◽  
pp. 1175-1197 ◽  
Author(s):  
K Walton ◽  
R Walker ◽  
J.J.M van de Sandt ◽  
J.V Castell ◽  
A.G.A.A Knapp ◽  
...  
Keyword(s):  
Food Additives ◽  
Daily Intake ◽  
Acceptable Daily Intake ◽  
Vitro Data ◽  
In Vitro Data

scholarly journals Evaluating Hazards Posed by Additives in Food: A Review of Studies Adopting a Risk Assessment Approach

2015 ◽  
Vol 3 (3) ◽  
pp. 243-255 ◽  
Author(s):  
Arushi Jain ◽  
Pulkit Mathur
Keyword(s):  
Risk Assessment ◽  
Health Risks ◽  
Food Industry ◽  
Food Additives ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Acceptable Daily Intake ◽  
Sunset Yellow ◽  
Assessment Approach ◽  
Multiple Scenarios

Processing and packaging has increased the use of food additives in the food industry. Some of these additives have associated health risks. This review looks at studies on risk assessment of food additives published between 2000-2015. These studies have majorly focused on synthetic food colors and preservatives like benzoate, sorbate, nitrite and nitrate. Most of the studies have shown that the intake was below the acceptable daily intake (ADI) for average consumers. For extreme consumers (95th percentile), intake was found to be above the ADI or approaching ADI for additives like sunset yellow FCF, erythrosine, tartrazine, sulphite, benzoate and nitrite. It is advisable to look at multiple scenarios of dietary exposure while evaluating risk. A surveillance system which documents adverse effects to food additives as well as monitors risk on a regular basis is important for every country to have. Such data would be beneficial to regulatory authorities as well as the industry in fixing usage levels of the additive in an effort to minimize health risk.

scholarly journals A review on assessment of acceptable daily intake for food additives

2020 ◽  
Vol 10 (4) ◽  
pp. 6033-6038
Keyword(s):  
Feature Fusion ◽  
Food Additives ◽  
Daily Intake ◽  
Specific Effect ◽  
Dose Effect ◽  
In Vitro Toxicity ◽  
Toxic Substances ◽  
Acceptable Daily Intake ◽  
Test Species ◽  
Toxicological Data

The acceptable daily intake (ADI) for food additives can be derived using ‘no observed adverse effect level’ (NOAEL) value obtained from in-vivo animal experiments. A safety factor (SF) of 100 is generally applied in calculation of NOAEL for the most sensitive test species to derive an ADI. The cent percent of SF is thought to be the result of individual differences in species having toxicology and toxicological dynamics. In this review, food additives are evaluated on the basis of available in-vitro toxicity data that could be used to derive the uncertainty factor. In addition, this paper describes the general methods adopted for assessing ADIs with the limitations inherent in these current methodologies. The methods mainly focus on a graphical display of toxicological data and estimate the acceptable intake from exposure periods for toxic substances rather than full life. Moreover, the method practices dose-response data or dose effect to calculate the decrease in the confidence level rare at the specific effect levels. These methods should lead to more inclination and be established by the Multi-type Feature Fusion (MFF) approach. It is by increasing the use of a full set of toxicological data.

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