scholarly journals Evaluating Hazards Posed by Additives in Food: A Review of Studies Adopting a Risk Assessment Approach

2015 ◽  
Vol 3 (3) ◽  
pp. 243-255 ◽  
Author(s):  
Arushi Jain ◽  
Pulkit Mathur
Keyword(s):  
Risk Assessment ◽  
Health Risks ◽  
Food Industry ◽  
Food Additives ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Acceptable Daily Intake ◽  
Sunset Yellow ◽  
Assessment Approach ◽  
Multiple Scenarios

Processing and packaging has increased the use of food additives in the food industry. Some of these additives have associated health risks. This review looks at studies on risk assessment of food additives published between 2000-2015. These studies have majorly focused on synthetic food colors and preservatives like benzoate, sorbate, nitrite and nitrate. Most of the studies have shown that the intake was below the acceptable daily intake (ADI) for average consumers. For extreme consumers (95th percentile), intake was found to be above the ADI or approaching ADI for additives like sunset yellow FCF, erythrosine, tartrazine, sulphite, benzoate and nitrite. It is advisable to look at multiple scenarios of dietary exposure while evaluating risk. A surveillance system which documents adverse effects to food additives as well as monitors risk on a regular basis is important for every country to have. Such data would be beneficial to regulatory authorities as well as the industry in fixing usage levels of the additive in an effort to minimize health risk.

scholarly journals Occurrence and Risk Assessment of Dietary Exposure to Deoxynivalenol in Wheat-Based Products Based Different Wheat-Producing Area for the Inhabitants in Shanghai, China

2021 ◽  
Vol 7 (12) ◽  
pp. 1015
Author(s):  
Xianli Yang ◽  
Zhiyong Zhao ◽  
Jianhua Wang ◽  
Junhua Yang ◽  
Hengchao E ◽  
...  
Keyword(s):  
Health Risks ◽  
Food Additives ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Expert Committee ◽  
Potential Health ◽  
Adverse Health Effects ◽  
Main Production ◽  
Daily Intakes ◽  
Production Areas

Deoxynivalenol (DON) is one of the major mycotoxins that contaminate cereals. In this study, we determined the DON level in wheat-based products from Chinese five main production areas collected in Shanghai and calculated the daily intake of DON for inhabitants using the point evaluation and the probabilistic evaluation based on Monte Carlo simulation. The results showed the positive rates of DON in the products were higher than 80.0%, with the concentrations ranging from 41.8 to 1110 µg/kg. The estimated mean daily intakes of DON for 7- to 10-year-old children and adults groups were below 1 µg/kg bw/day, the provisional maximum tolerable daily intake (PMTDI) set by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), suggesting no health risks for the consumers. However, the 99th percentiles of dietary DON exposures for children and adults exceeded the PMTDI, indicating adverse health effects might occur if the two groups intake highly contaminated wheat-based products. The potential health risks for the two groups exposed to DON in the wheat-based products from the Middle and Lower Yangtze Valley (MLYV) were higher than those from the other areas in China.

Risk Assessment of Sulphite Exposure through Foods Among Adolescents of Delhi (India)

2019 ◽  
Vol 15 (7) ◽  
pp. 685-693
Author(s):  
Arushi Jain ◽  
Pulkit Mathur
Keyword(s):  
Risk Assessment ◽  
Food Intake ◽  
Daily Intake ◽  
Food Sources ◽  
Acceptable Daily Intake ◽  
Food Record ◽  
Government Schools ◽  
Adverse Health Effects ◽  
Food Items ◽  
Permissible Levels

Background: Sulphites added as preservatives in food have been associated with adverse health effects in humans. Objective: The present study was designed with an objective of assessing the risk of sulphite exposure through food in adolescents (12-16 years old) of Delhi, India. Methods: A total of 1030 adolescents selected from four private and four government schools of Delhi, were asked to record their food intake using a 24 hour food record, repeated on three days, for assessing exposure to sulphites. The risk was assessed using six different scenarios of exposure. Results: The actual intake for sulphites for average consumers was 0.15 ± 0.13 mg / kg b.w. / day which was 21.4% of acceptable daily intake (ADI). For high consumers (P95), it was 65% of the ADI. However, for 2 respondents, the actual intake exceeded the ADI. The major food contributors to sulphite intake were beverage concentrates (46%), ready to serve beverages (22%) followed by miscellaneous food items (16%), mainly ice creams and snowballs. Estimation of sulphite intake using different exposure scenarios revealed that for certain scenarios where the highest reported sulphite level or maximum permissible levels were considered for calculation, the high consumers exceeded the ADI, though, for average consumers, intake was well below the ADI. Conclusion: Actual intake of sulphite for average consumers was well below the ADI but for high consumers was approaching the ADI. People with sulphite sensitivity need to be aware of hidden food sources of sulphites.

Portable solid-state potentiometric sensor based on polymeric ion-exchanger for the assay of the controversial food colorant (sunset yellow)

2021 ◽  
Author(s):  
Manar Omar Heragy ◽  
Azza Mustafa ◽  
Eman Elzanfaly ◽  
Ahmed Sayed Saad
Keyword(s):  
Solid State ◽  
Food Additives ◽  
Daily Intake ◽  
Food Products ◽  
Potentiometric Sensor ◽  
Ion Exchanger ◽  
Sunset Yellow ◽  
Food Colorant

Food additives are chemicals added to enhance appearance, taste, or lifetime of food products. Authorities continuously update lists of the allowed additives and their daily intake limits. Thus, authorities and...

scholarly journals Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

2018 ◽  
Vol 15 (11) ◽  
pp. 2336 ◽  
Author(s):  
Maryam Zare Jeddi ◽  
Mohamad Eshaghi Gorji ◽  
Ivonne Rietjens ◽  
Jochem Louisse ◽  
Yuri Bruinen de Bruin ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Children And Adolescents ◽  
Health Risks ◽  
Safety Concern ◽  
Hazard Quotient ◽  
Daily Intake ◽  
Hazard Index ◽  
Internal Exposure ◽  
Combined Exposure ◽  
Iranian Children

This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolescents aged 6 to 18 years by analyzing seven urinary metabolites of five phthalates. The estimated daily intake values derived from the biomonitoring data ranged from 0.01 µg/kg bw/day for butyl benzyl phthalate (BBP), to 17.85 µg/kg bw/day for di(2-ethylhexyl) phthalate (DEHP). The risk assessment revealed that not only the exposure to the individual phthalates, but also the combined exposure to the three anti-androgenic phthalates (DEHP, DBP, BBP) did not raise a safety concern (hazard index values averaged 0.2). The range of maximum cumulative ratio values varied from around 1 for most individuals to around 2 in some individuals, indicating that the combined exposures were dominated by one and in some cases by two of the three anti-androgenic phthalates, especially dibutyl phthalate (DBP) and/or DEHP. Based on biomonitoring data, the overall combined exposure of Iranian children to phthalates does not raise a concern, while reduction of exposure is best focused on DEHP and DBP that showed the highest hazard quotient.

Contents and Risk Assessment of Heavy Metals in Marine Invertebrates from Korean Coastal Fish Markets

2014 ◽  
Vol 77 (6) ◽  
pp. 1022-1030 ◽  
Author(s):  
JONG SOO MOK ◽  
JI YOUNG KWON ◽  
KWANG TAE SON ◽  
WOO SEOK CHOI ◽  
SUNG RIM KANG ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Risk Assessment ◽  
Marine Invertebrates ◽  
Marine Invertebrate ◽  
Food Additives ◽  
Daily Intake ◽  
Hazard Index ◽  
Human Consumption ◽  
Expert Committee ◽  
Consumer Safety

The concentrations of the heavy metals cadmium (Cd), mercury (Hg), lead (Pb), chromium, silver, nickel, copper, and zinc in the edible portions of 105 marine invertebrates representing 16 mollusk and crustacean species were accurately determined to evaluate their hazard for human consumption. The samples were collected in 2011 from major fish markets on the coast of Korea and analyzed for Hg using a direct Hg analyzer and for other metals using inductively coupled plasma mass spectrometry. Estimated dietary exposure (EDE) was determined, and a risk assessment was made of the heavy metals to provide information concerning consumer safety. The Cd concentrations, which were the highest for the three hazardous metals (Cd, Hg, and Pb), were significantly higher (P < 0.05) in the bivalves and crabs than in the gastropods and cephalopods. However, the concentrations of these metals in all samples were within the regulatory limits set by Korea and other countries. The EDE was compared with the provisional tolerable daily intake (PTDI) adopted by the Joint FAO/WHO Expert Committee on Food Additives or the U.S. Environmental Protection Agency. The EDE of Cd, Hg, and Pb for each class of marine invertebrate were 0.07 to 2.64, 0.01 to 0.43, and 0.001 to 0.16% of the PTDI, respectively. The total EDE of Cd, Hg, and Pb for marine invertebrates accounted for 4.03, 0.96, and 0.21%, respectively, of the PTDI. The EDE of other metals in each class of marine invertebrate was less than 2% of the PTDI. The hazard index is a reasonable parameter for assessing the risk of heavy metal consumption associated with contaminated food. In the present study, the hazard index for all of the species was less than 1.0, which indicates that the intake of heavy metals from consumption of these marine invertebrates does not represent an appreciable hazard to humans.

Conditions for Use of Food Additives Based on a Budget for an Acceptable Daily Intake1

1979 ◽  
Vol 42 (5) ◽  
pp. 429-434 ◽  
Author(s):  
SØREN C. HANSEN
Keyword(s):  
Body Weight ◽  
Food Additives ◽  
Daily Intake ◽  
Common Market ◽  
Regulatory Agencies ◽  
Acceptable Daily Intake ◽  
Quantitative Expression ◽  
Total Intake ◽  
The Difference ◽  
Food And Drink

Use of food additives is regulated qualitatively in the European Common Market through the EEC directives on food additives, while the concept of Acceptable Daily Intake (ADI) provides a quantitative expression of safe amounts for the guidance of regulatory agencies. It is suggested that a permissible quantity or quantities, the ceiling, should be agreed upon for each permitted additive on the basis of its ADI and in accordance with the procedure described here. The estimation of intake of food and drink starts from the child, who on the basis of body weight has the highest consumption. When dealing with total intake (expressed as energy, weight or volume per kg body weight per day), occupational and climatical variations between adults are largely contained in the difference between child and adult. It is possible to calculate the highest concentration in foodstuffs which is consistent with the ADI, under the assumption that the additive occurs evenly distributed in the whole diet of a child. This concentration is called the primary ceiling. To obtain the technological effect, however, higher concentrations may be needed, and to accomodate this the ceiling may have to be raised. This can be done if the use of the additive can be excluded from or reserved for part of the diet.

scholarly journals Jurnal_TEDC Vol. 10 No. 3 September 2016

2019 ◽  
Author(s):  
Lusi Marlina
Keyword(s):  
Body Weight ◽  
Chemical Engineering ◽  
Food Additives ◽  
Daily Intake ◽  
Gravimetric Method ◽  
Artificial Sweeteners ◽  
Artificial Sweetener ◽  
Acceptable Daily Intake ◽  
Constant Weight ◽  
Fixed Constant

IDENTIFIKASI KANDUNGAN SIKLAMAT PADA MINUMANYANG DIJUAL DI PINGGIR JALAN CIHAMPELASSAMPAI JALAN BATUJAJARLusi Marlina*, Annisa Rani Sa’adah**Program Studi Teknik Kimia, Politeknik TEDC BandungJalan Pasantren Km 2 Cibabat Cimahi Utara 40513Email: [email protected] buatan adalah bahan tambahan makanan yang ditambahkan dalam makanan atau minuman untukmenciptakan rasa manis. Siklamat merupakan jenis pemanis buatan yang memiliki kemanisan 30 kali lebihmanis dari pada sukrosa. Pemakaian pemanis sintetis masih diragukan keamanannya bagi kesehatankonsumen, Beberapa negara mengeluarkan peraturan secara ketat atau bahkan melarang penggunaannya,seperti kanada sejak 1977. Batas Maksimum Penggunaan Siklamat yang diatur dalam ADI (acceptable dailyintake) atau kebutuhan per orang per hari adalah sebanyak 0 – 11 mg per berat badan per hari. Sementarakadar maksimum siklamat dalam minuman 3 gr/L. Untuk mengidentifikasi kandungan siklamat pada minumandapat menggunakan metode gravimetri. metode gravimetri adalah cara analisis kuantitatif berdasarkan berattetap (berat konstannya). Penelitian ini bertujuan untuk mengidentifikasi kandungan siklamat pada minumanyang dijual di pinggir jalan. Dengan mengambil 6 sampel minuman. Pengujian dilakukan di laboratoriumteknik kimia Politeknik TEDC Bandung. Berdasarkan hasil penelitian secara kuantitatif dari 6 sampel seluruhsampel terdeteksi mengandung siklamat, dengan kadar terendah 3 mg dan kadar tertinggi 14,3 mg.Kata kunci: Minuman jajanan, Pemanis Buatan, Siklamat.AbstractAn artificial sweeteners are the food additives that are added to foods or beverages to create a sweet taste.Cyclamate is a kind of artificial sweetener that has a sweetness 30 times sweeter than sucrose. The use ofartificial sweeteners is still questionable safety for the health of consumers, some countries issue regulationsstrictly or even prohibit its use, such as Canada since 1977. Limit Use of Cyclamates set out in the ADI(acceptable daily intake) or requirement per person per day is as much as 0-11 mg per body weight per day.While the maximum levels of cyclamate in drinks 3 g / L. To identify the content of cyclamate in beveragescan using gravimetric methods. gravimetric method is a method of quantitative analysis based on the weightof fixed (constant weight). This study aims to identify the content of cyclamate in drinks sold on the roadside.By taking 6 samples drinks. Tests conducted in the laboratory of chemical engineering TEDC PolytechnicBandung. Based on the results of a quantitative study of 6 samples throughout the sample is detected tocontain cyclamate, with the lowest levels of 3 mg and the highest levels of 14.3 mg.Keywords: Hawker food, An artificial sweeteners, cyclamate

scholarly journals Health Risks associated with residual pesticide levels in fish reared in purified wastewater from slaughterhouse

2020 ◽  
Vol 71 (1) ◽  
pp. 1991 ◽  
Author(s):  
M. PELIĆ ◽  
B. KARTALOVIĆ ◽  
M. ŽIVKOV BALOŠ ◽  
M. MIRILOVIĆ ◽  
M. ĐORĐEVIĆ ◽  
...  
Keyword(s):  
Health Risks ◽  
Daily Intake ◽  
Acceptable Daily Intake ◽  
Slaughterhouse Wastewater ◽  
Fresh Fish ◽  
Low Concentrations ◽  
Different Seasons ◽  
Previously Treated ◽  
Residual Pesticide ◽  
Carp Fish

The main objective of the present research was to determine the concentrations of the selected pesticides in muscle, liver and skin of common carp. Fish were sampled in two different seasons from fish pond which received previously treated slaughterhouse wastewater. Pesticides including etridiazole, chloroneb, trifluralin, propachlor, chlorothalonil, hexa-chlorocyclopentadiene, atrazine, simazine, alachlor, metribuzin, metolachlor, DCPA, cyanazine, chlorobenzilate, endrin aldehyde, cis permethrin and trans permethrin were determined by using a GS-MS method. Many of pesticides were not determined or determined in low concentrations. Propachlor was found in muscle, skin and liver. The recommended acceptable daily intake was higher in comparison with the estimated daily intake for examined pesticides via fish reared in treated slaughterhouse wastewater. It is very important to maintain the safety of the fresh fish produced in wastewater in order to ensure food safety and avoid health problems in humans.

Risk assessment of dietary exposure to methylmercury in fish in the UK

2007 ◽  
Vol 26 (3) ◽  
pp. 185-190 ◽  
Author(s):  
B J Maycock ◽  
D J Benford
Keyword(s):  
Risk Assessment ◽  
Dietary Exposure ◽  
Epidemiological Studies ◽  
Consumer Products ◽  
Laboratory Animals ◽  
Human Data ◽  
Toxicological Studies ◽  
Assessment Approach ◽  
Nutritional Data ◽  
The Uk

Risk assessment of chemicals in food is generally based upon the results of toxicological studies in laboratory animals, allowing for uncertainties relating to interspecies differences, human variability, and gaps in the database. Use of quantitative human data is preferable if available, as in the example of methylmercury. Methylmercury is a neurotoxic environmental contaminant, for which fish is the main source of dietary exposure. Human data from poisoning incidents and epidemiological studies have been used by expert committees to derive a guideline intake level for methylmercury, based on the susceptibility of the most sensitive lifestage, the developing fetus. In the UK, an expert group of nutritionists and toxicologists was formed to review the benefits and risks associated with fish consumption. A formal risk–benefit analysis was not possible because the nutritional data were not sufficiently quantitative. The Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT), therefore, modified the risk assessment approach to derive different guideline intake levels for different subgroups of the population. The COT opinion was used to provide targeted advice on how much fish can be consumed without undue risk from the contaminants. Consumption by adults of one weekly portion (140 g) of shark, swordfish or marlin, would lead to an exceedance of the guideline intake for methylmercury of 40–90%, set to protect the developing fetus, without considering intake from the rest of the diet. Pregnant women and women who may become pregnant within 1 year were, therefore, advised to avoid consumption of these species. Intakes in other adults would be within a higher guideline intake, set to protect groups of the population other than the developing fetus. However, consumption by children of one weekly portion of these species could lead to an exceedance of this guideline intake by up to 60%, without considering intake from the rest of the diet. It was, therefore, advised that consumption of these species by children should be avoided.

Food additives on acceptable daily intake (ADI) level affect the agonist induced platelet activation I. Antioxidants and preservatives

Chemosphere ◽  
1994 ◽  
Vol 29 (6) ◽  
pp. 1293-1299
Author(s):  
Hiroyasu Yamazaki ◽  
Takako Yamaguchi ◽  
Aiko Yamauchi ◽  
Yasuo Kakiuchi
Keyword(s):  
Platelet Activation ◽  
Food Additives ◽  
Daily Intake ◽  
Acceptable Daily Intake
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