4426371 Novel N-hydroxyalkylated dicarboxylic acid BIS(3,5- dicarbamoyl-2,4, 6- triiodoanilides), as x-ray contrast media

1985 ◽  
Vol 12 (3) ◽  
pp. ix
2021 ◽  
pp. 028418512110198
Author(s):  
Frank Mosler ◽  
Johannes K Richter ◽  
Marc Schindewolf ◽  
Nando Mertineit ◽  
Hendrik von Tengg-Kobligk ◽  
...  

X-ray contrast media have been reported to have inhibitory effects on bacterial growth. Despite its potentially beneficial effect on patients, these features of contrast media have received relatively little attention in the medical literature in the past decades. The aim of this review is to evaluate the literature concerning the bactericidal and bacteriostatic effects of X-ray contrast media, specifically if there is a known difference concerning these effects between ionic and non-ionic contrast media. Systematic literature review was performed for the years of publication between 1911 and 2019. Since the publication of Grossich in 1911, the effect of iodine on the treatment of superficial infections in surgical procedures has been established clinical knowledge. Bacteriostatic and bactericidal effects of ionic X-ray contrast media are well established. However, non-ionic contrast agents have been the subject of little research in this respect. In past decades, the hypothesis emerged in the literature that mainly the concentration of free iodine might be responsible for any bacteriostatic or bactericidal effect of ionic X-ray contrast media. Nowadays, however, only non-ionic contrast media are used. The question regarding the mechanism and magnitude of bacteriostatic or bactericidal effects of these, non-ionic contrast media, could not be answered conclusively from this review. Non-ionic contrast media could be used intentionally when a local antibacterial effect is intended (e.g. in percutaneous abscess drainage), as well as to reduce the overall dose of antibiotics administered to a patient. Thus, this question remains relevant and might constitute the area of future research.


2004 ◽  
Vol 50 (5) ◽  
pp. 261-268 ◽  
Author(s):  
S. Schittko ◽  
A. Putschew ◽  
M. Jekel

After bank filtration, effluent influenced surface waters are often used as raw drinking water. It is known that high concentrations of iodinated X-ray contrast media are detectable in such surface waters and thus, more knowledge about the behaviour of the contrast media during bank filtration is necessary and the subject of investigations in this study. The adsorbable organic iodine (AOI), four widely used iodinated X-ray contrast media and four possible transformation products were quantified in an influenced lake, five groundwater wells and a drinking water well. Under anoxic conditions the AOI as well as the concentration of the contrast media are decreased by bank filtration, whereby the AOI is decreased by 64% and the contrast media concentration can be reduced up to 95%, depending on the compound. In the raw drinking water the following average concentrations were determined: Iopromid <20 ng/L, Diatrizote 166 ng/L, Iopamidol 166 ng/L and Iohexol 34 ng/L. Instationary conditions during the sampling period indicate that, at least under anoxic conditions, a large part of the contrast media and transformation products, which are still iodinated, may be associated to colloids and/or humic material.


Author(s):  
P. Vojtíšek ◽  
I. Císařová ◽  
J. Podlaha ◽  
Z. Žák ◽  
S. Böhm ◽  
...  

AbstractCrystal structures of the title compounds were determined by single crystal X-ray diffraction. Absolute configuration of the barium salt of (+)-(


2005 ◽  
Vol 44 (12) ◽  
pp. 8716-8721 ◽  
Author(s):  
Eiichi Sato ◽  
Yasuomi Hayasi ◽  
Koji Kimura ◽  
Etsuro Tanaka ◽  
Hidezo Mori ◽  
...  
Keyword(s):  

1979 ◽  
Vol 2 (4) ◽  
pp. 461-462 ◽  
Author(s):  
A. Costa ◽  
I. J. Chopra ◽  
D. H. Solomon ◽  
S. Y. Wu
Keyword(s):  

2003 ◽  
Vol 40 (7) ◽  
pp. 457-463 ◽  
Author(s):  
Ikuo KANNO ◽  
Satoshi MAETAKI ◽  
Hisatoshi AOKI ◽  
Seiichiro NOMIYA ◽  
Hideaki ONABE

2017 ◽  
Vol 23 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Asghar Mesbahi ◽  
Fatemeh Famouri ◽  
Mohammad Johari Ahar ◽  
Maryam Olade Ghaffari ◽  
Seyed Mostafa Ghavami

AbstractAim: In the current study, some imaging characteristics of AuNPs were quantitatively analyzed and compared with two conventional contrast media (CM) including Iodine and Gadolinium by using of a cylindrical phantom.Methods: AuNPs were synthesized with the mean diameter of 16 nm and were equalized to the concentration of 0.5, 1, 2 and 4 mg/mL in the same volumes. A cylindrical phantom resembling the head and neck was fabricated and drilled to contain small tubes filled with Iodine, Gadolinium, and AuNPs as contrast media. The phantom was scanned in different exposure techniques and CT numbers of three studied contrast media inside test tubes were measured in terms of Hounsfield Unit (HU). The imaging parameters of the noise and contrast to noise ratios (CNR) were calculated for all studied CMs.Results: AuNPs showed 128% and 166% higher CT number in comparison with Iodine and Gadolinium respectively. Also, Iodine had a greater CT number than Gadolinium for the same exposure techniques and concentration. The maximum CT number for AuNPs and studied contrast materials was obtained at the highest mAs and the lowest tube potential. The maximum CT number were 1033±11 (HU) for AuNP, 565±10 (HU) for Iodine, 458±11 for Gadolinium. Moreover, the maximum CNRs of 433±117, 203±53, 145±37 were found for AuNPs, Iodine and Gadolinium respectively.Conclusion: The contrast agent based on AuNPs showed higher imaging quality in terms of contrast and noise relative to other iodine and gadolinium based contrast media in X-ray computed tomography. Application of the AuNPs as a contrast medium in x-ray CT is recommended.


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