scholarly journals Ionic and non-ionic intravenous X-ray contrast media: antibacterial agents?

2021 ◽  
pp. 028418512110198
Author(s):  
Frank Mosler ◽  
Johannes K Richter ◽  
Marc Schindewolf ◽  
Nando Mertineit ◽  
Hendrik von Tengg-Kobligk ◽  
...  
Keyword(s):  
Contrast Media ◽  
Bactericidal Effect ◽  
Future Research ◽  
Inhibitory Effects ◽  
X Ray ◽  
Percutaneous Abscess Drainage ◽  
Ionic Contrast ◽  
Bactericidal Effects ◽  
Free Iodine ◽  
The Subject

X-ray contrast media have been reported to have inhibitory effects on bacterial growth. Despite its potentially beneficial effect on patients, these features of contrast media have received relatively little attention in the medical literature in the past decades. The aim of this review is to evaluate the literature concerning the bactericidal and bacteriostatic effects of X-ray contrast media, specifically if there is a known difference concerning these effects between ionic and non-ionic contrast media. Systematic literature review was performed for the years of publication between 1911 and 2019. Since the publication of Grossich in 1911, the effect of iodine on the treatment of superficial infections in surgical procedures has been established clinical knowledge. Bacteriostatic and bactericidal effects of ionic X-ray contrast media are well established. However, non-ionic contrast agents have been the subject of little research in this respect. In past decades, the hypothesis emerged in the literature that mainly the concentration of free iodine might be responsible for any bacteriostatic or bactericidal effect of ionic X-ray contrast media. Nowadays, however, only non-ionic contrast media are used. The question regarding the mechanism and magnitude of bacteriostatic or bactericidal effects of these, non-ionic contrast media, could not be answered conclusively from this review. Non-ionic contrast media could be used intentionally when a local antibacterial effect is intended (e.g. in percutaneous abscess drainage), as well as to reduce the overall dose of antibiotics administered to a patient. Thus, this question remains relevant and might constitute the area of future research.

Intrathyroidal iodine concentration after application of non-ionic contrast media with and without prophylactic application of perchlorate

2005 ◽  
Vol 44 (04) ◽  
pp. 143-148 ◽  
Author(s):  
K. Schaffhauser ◽  
H. Hänscheid ◽  
J. Rendl ◽  
I. Grelle ◽  
Chr. Reiners
Keyword(s):  
Contrast Media ◽  
Concomitant Medication ◽  
Fluorescence Analysis ◽  
Iodine Concentration ◽  
Iodine Uptake ◽  
Initial Concentration ◽  
X Ray ◽  
Oral Application ◽  
Nonionic Contrast Medium ◽  
Ionic Contrast

Summary Aim: This study was designed to show the effect of a nonionic contrast medium (Iomeprol-300; CM) on the intrathyroidal iodine concentration with and without a concomitant medication with perchlorate (1380 mg/d) to block the thyroidal iodine uptake. Volunteers and methods: Twelve volunteers recieved 100 ml Iomeprol-300 intravenously and the perchlorate prophylaxis mentioned above. Another 12 volunteers got 100 ml Iomeprol-300 only. By means of X-ray-fluorescence-analysis the intrathyroidal iodine concentration was determined in advance as well as 0.2, 1, 3, 5, 7, 24, 48, 72, and 96 hours after the application of the CM. Results, Conclusion: The intrathyroidal iodine concentration did not change in the group of volunteers on perchlorate medication. Without perchlorate the intrathyroidal iodine concentration decreased after the application of the CM when it was initially high (722 ± 66 μg/ml before, 670 ± 65 μg/ml after CM; p = 0.046) and increased in case of a low initial concentration (327 ± 40 μg/ml before, 381 ± 25μg/ml after CM; p = 0.046). The effect is significant but its magnitude is too small to be harmful for a patient with a healthy thyroid. The oral application of 1.4 g/d perchlorate inhibits the thyroidal iodine uptake and the intrathyroidal iodine concentration is unaffected by the application of a CM.

Cellular Toxicity of X-ray Contrast Media for Two Renal Epithelial Cell Lines (MDCK and LLC-PK1)

1992 ◽  
Vol 20 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Knut-Jan Andersen ◽  
Eckart Holtz ◽  
Hogne Vik
Keyword(s):  
Contrast Media ◽  
Cell Lines ◽  
Toxicity Testing ◽  
Distal Tubule ◽  
Renal Epithelial Cell ◽  
X Ray ◽  
Biochemical Assays ◽  
Ionic Contrast ◽  
Epithelial Cell Lines ◽  
Ionic Monomer

The two renal cell lines, MDCK (distal tubule) and LLC-PK1 (proximal tubule), have been used for toxicity testing of three different X-ray contrast media: the ionic monomer Isopaque, the ionic dimer Hexabrix and the non-ionic monomer Omnipaque. The cells were grown to confluency in monolayer cultures in a chemically-defined serum-free medium before the contrast media were added, to give final concentrations corresponding to 0–100mg iodine/ml. Toxicity was assessed by cell viability and by biochemical assays of marker enzymes. The results demonstrate a concentration-dependent toxic effect from the contrast media on cellular appearance, and on the activity of brush border and lysosomal enzymes. The non-ionic X-ray contrast media appeared to be less toxic than the ionic contrast media investigated.

A Systematic Literature Review of the EFQM Excellence Model from 1991 to 2019

1970 ◽  
Vol 2 (2) ◽  
pp. 11-15
Author(s):  
Muhammad Yousaf ◽  
Petr Bris
Keyword(s):  
Quality Management ◽  
Data Collection ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Quantitative Research ◽  
Web Of Science ◽  
State Of The Art ◽  
Future Research ◽  
European Foundation ◽  
The Subject

A systematic literature review (SLR) from 1991 to 2019 is carried out about EFQM (European Foundation for Quality Management) excellence model in this paper. The aim of the paper is to present state of the art in quantitative research on the EFQM excellence model that will guide future research lines in this field. The articles were searched with the help of six strings and these six strings were executed in three popular databases i.e. Scopus, Web of Science, and Science Direct. Around 584 peer-reviewed articles examined, which are directly linked with the subject of quantitative research on the EFQM excellence model. About 108 papers were chosen finally, then the purpose, data collection, conclusion, contributions, and type of quantitative of the selected papers are discussed and analyzed briefly in this study. Thus, this study identifies the focus areas of the researchers and knowledge gaps in empirical quantitative literature on the EFQM excellence model. This article also presents the lines of future research.

Antibacterial silver-diatomite nanocomposite ceramic with low silver release

2019 ◽  
Vol 20 (2) ◽  
pp. 633-643
Author(s):  
Xiaopeng Qi ◽  
Junwei Chen ◽  
Qian Li ◽  
Hui Yang ◽  
Honghui Jiang ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Water Treatment ◽  
Photoelectron Spectroscopy ◽  
Bactericidal Effect ◽  
Ceramic Filter ◽  
Ceramic Filters ◽  
X Ray ◽  
E Coli ◽  
Point Of Use ◽  
Silver Release

Abstract There is an urgent need for an effective and long-lasting ceramic filter for point-of-use water treatment. In this study, silver-diatomite nanocomposite ceramic filters were developed by an easy and effective method. The ceramic filters have a three-dimensional interconnected pore structure and porosity of 50.85%. Characterizations of the silver-diatomite nanocomposite ceramic filters were performed using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Silver nanoparticles were confirmed to be formed in situ in the ceramic filter. The highest silver concentration in water was 0.24 μg/L and 2.1 μg/L in short- and long-term experiments, indicating very low silver-release properties of silver-diatomite nanocomposite ceramic filter. The nanocomposite ceramics show strong bactericidal activity. When contact time with Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) of 105 colony forming units (CFU)/mL exceeded 3 h, the bactericidal rates of the four different silver content ceramics against E. coli and S. aureus were all 100%. Strong bactericidal effect against E. coli with initial concentration of 109 CFU/mL were also observed in ceramic newly obtained and ceramic immersed in water for 270 days, demonstrating its high stability. The silver-diatomite nanocomposite ceramic filters could be a promising candidate for point-of-use water treatment.

scholarly journals Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?

2021 ◽  
Vol 22 (12) ◽  
pp. 6222
Author(s):  
Kacper Szewczyk ◽  
Aleksandra Chojnacka ◽  
Magdalena Górnicka
Keyword(s):  
Vitamin E ◽  
Metabolic Disorders ◽  
Tissue Concentration ◽  
Biological Properties ◽  
Biological Role ◽  
Future Research ◽  
The Past ◽  
The Subject ◽  
The Relationship

Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the highest content in food products. Nevertheless, α-tocopherol is the main form of vitamin E with the highest tissue concentration. The α- forms of both tocopherols and tocotrienols are considered as the most metabolically active. Currently, research results indicate also a greater antioxidant potential of tocotrienols than tocopherols. Moreover, the biological role of vitamin E metabolites have received increasing interest. The aim of this review is to update the knowledge of tocopherol and tocotrienol bioactivity, with a particular focus on their bioavailability, distribution, and metabolism determinants in humans. Almost one hundred years after the start of research on α-tocopherol, its biological properties are still under investigation. For several decades, researchers’ interest in the biological importance of other forms of vitamin E has also been growing. Some of the functions, for instance the antioxidant functions of α- and γ-tocopherols, have been confirmed in humans, while others, such as the relationship with metabolic disorders, are still under investigation. Some studies, which analyzed the biological role and mechanisms of tocopherols and tocotrienols over the past few years described new and even unexpected cellular and molecular properties that will be the subject of future research.

Sustainability Certification and Green Public Procurement: Ideals and Outcomes in a New Jersey School District

2021 ◽  
pp. 097340822110125
Author(s):  
Cluny Mendez ◽  
Christopher L. Atkinson
Keyword(s):  
New Jersey ◽  
School District ◽  
School Districts ◽  
Best Practices ◽  
Public Procurement ◽  
Lessons Learned ◽  
Future Research ◽  
Review Of The Literature ◽  
Green Public Procurement ◽  
The Subject

The implementation of sustainability and green public procurement (GPP) initiatives in school districts has been the subject of some debate; questions over definitions and programme goals have led to inconsistency and concerns about programme achievements. The legitimacy of programmes rests not only with the announcement of policy by officials, but with adherence to policy and staff buy-in. This study examines barriers districts face, and makes recommendations based upon district experience on ways to successfully implement sustainability and GPP initiatives. A review of the literature on GPP and legitimacy in the execution of public functions within the education domain begins the study. Major components relative to best practices for GPP programmes are studied through the review of GPP-related documents from a school district in New Jersey considered as an exemplar of such programmes. Analysis of an interview with the district’s representatives suggests that, despite the normative approval such programmes receive, and widespread understanding of the rationale for pursuing such initiatives, there remain critical failings in implementation of these programmes, stemming from education, resourcing of initiatives and prioritization of green procurement in relation to other district priorities. The study concludes with lessons learned from this case, which is important given its positioning within New Jersey as an exemplar and recommendations for future research where work in this area is needed.

A Review of Process Tomography Application in Inspection System

2014 ◽  
Vol 70 (3) ◽  
Author(s):  
Yasmin Abdul Wahab ◽  
Ruzairi Abdul Rahim ◽  
Mohd Hafiz Fazlul Rahiman ◽  
Herlina Abdul Rahim ◽  
Suzanna Ridzuan Aw ◽  
...  
Keyword(s):  
Electrical Impedance ◽  
Optical Tomography ◽  
Good Condition ◽  
Future Research ◽  
Inspection System ◽  
Ultrasonic Tomography ◽  
Impedance Tomography ◽  
X Ray ◽  
Process Tomography ◽  
Non Destructive

The inspection system is crucial to ensure the system is always in a good condition. A technique that can be used for inspection system is process tomography. By promising non-destructive approach; various types of process tomography applied in civil, manufacturing and electrical applications. The purpose of this paper is to review the types of process tomography such as ultrasonic tomography, x-ray tomography, optical tomography, electrical resistance tomography, and electrical impedance tomography that had been applied to the inspection system. Variety techniques of inspection based on those sensors briefly discussed in this paper. The result showed that the process tomography expanded tremendously in the inspection system. Finally, a potential future research on the inspection system in the civil application proposed in this paper.

Bank filtration: a suitable process for the removal of iodinated X-ray contrast media?

2004 ◽  
Vol 50 (5) ◽  
pp. 261-268 ◽  
Author(s):  
S. Schittko ◽  
A. Putschew ◽  
M. Jekel
Keyword(s):  
Drinking Water ◽  
Contrast Media ◽  
Surface Waters ◽  
Sampling Period ◽  
Transformation Products ◽  
Bank Filtration ◽  
Anoxic Conditions ◽  
X Ray ◽  
High Concentrations ◽  
Media Concentration

After bank filtration, effluent influenced surface waters are often used as raw drinking water. It is known that high concentrations of iodinated X-ray contrast media are detectable in such surface waters and thus, more knowledge about the behaviour of the contrast media during bank filtration is necessary and the subject of investigations in this study. The adsorbable organic iodine (AOI), four widely used iodinated X-ray contrast media and four possible transformation products were quantified in an influenced lake, five groundwater wells and a drinking water well. Under anoxic conditions the AOI as well as the concentration of the contrast media are decreased by bank filtration, whereby the AOI is decreased by 64% and the contrast media concentration can be reduced up to 95%, depending on the compound. In the raw drinking water the following average concentrations were determined: Iopromid <20 ng/L, Diatrizote 166 ng/L, Iopamidol 166 ng/L and Iohexol 34 ng/L. Instationary conditions during the sampling period indicate that, at least under anoxic conditions, a large part of the contrast media and transformation products, which are still iodinated, may be associated to colloids and/or humic material.

Enhanced K-edge Angiography Utilizing Tantalum Plasma X-ray Generator in Conjunction with Gadolinium-Based Contrast Media

2005 ◽  
Vol 44 (12) ◽  
pp. 8716-8721 ◽  
Author(s):  
Eiichi Sato ◽  
Yasuomi Hayasi ◽  
Koji Kimura ◽  
Etsuro Tanaka ◽  
Hidezo Mori ◽  
...  
Keyword(s):  
Contrast Media ◽  
X Ray
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