Poly(2-hydroxyethyl methacrylate) sponges as implant materials: in vivo and in vitro evaluation of cellular invasion

Biomaterials ◽  
1993 ◽  
Vol 14 (1) ◽  
pp. 26-38 ◽  
Author(s):  
Traian V. Chirila ◽  
Ian J. Constable ◽  
Geoffrey J. Crawford ◽  
Sarojini Vijayasekaran ◽  
Dawn E. Thompson ◽  
...  
Keyword(s):  
Hydroxyethyl Methacrylate ◽  
In Vitro Evaluation ◽  
Cellular Invasion ◽  
Implant Materials

The Use of the Chorioallantoic Membrane (CAM) of the Embryonic Chick for the Direct Assessment of Implant Toxicity

1985 ◽  
Vol 13 (4) ◽  
pp. 261-266
Author(s):  
P.P. Monro ◽  
D.P. Knight ◽  
W.S. Pringle ◽  
D.M. Fyfe ◽  
J.R. Shearer
Keyword(s):  
Chorioallantoic Membrane ◽  
In Vitro Techniques ◽  
Implant Materials ◽  
Metal Foils ◽  
Complex Interactions ◽  
Cobalt Nickel ◽  
Histological Criteria ◽  
Fluid Environment

The toxicity of implant materials requires investigation prior to clinical use. We have developed a method where materials are directly applied to the chorioallantoic membrane (CAM) of 9-day-old chick embryos and toxicity is assessed using histological criteria. We evaluated the method using metal foils. The number and organisation of fibroblasts seemed to be the most useful criteria for assessing metal toxicity. Differences were greatest after 10 days of culture on the CAM. The method is sensitive enough to enable us to discriminate between the less toxic aluminium and titanium and the highly toxic cobalt, nickel and tungsten. The proposed method has advantages over in vitro techniques which provide an abnormal fluid environment and in which the more complex interactions that are possible between implant materials and tissue in vivo cannot be modelled.

In vivo and in vitro evaluation of the corneal damage induced by 1573 nm laser radiation

2008 ◽  
Vol 20 (2) ◽  
pp. 69-75
Author(s):  
Daniel Courant ◽  
Catherine Chapel ◽  
Céline Billy ◽  
Nicole Salès ◽  
Jean-Claude Pérot ◽  
...  
Keyword(s):  
Laser Radiation ◽  
In Vitro Evaluation ◽  
Corneal Damage

Niosomes for enhanced activity of praziquantel against Schistosoma mansoni: in vivo and in vitro evaluation

2018 ◽  
Vol 118 (1) ◽  
pp. 219-234 ◽  
Author(s):  
Hager S. Zoghroban ◽  
Samy I. El-Kowrany ◽  
Ibrahim A. Aboul Asaad ◽  
Gamal M. El Maghraby ◽  
Kholoud A. El-Nouby ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
In Vitro Evaluation ◽  
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