The use of isotope dilution mass spectrometry for the certification of standard reference materials

1984 ◽  
Vol 10 (2) ◽  
pp. 169-173 ◽  
Author(s):  
Larry J. Moore ◽  
Howard M. Kingston ◽  
Thomas J. Murphy ◽  
Paul J. Paulsen
Keyword(s):  
Mass Spectrometry ◽  
Reference Materials ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Standard Reference Materials

Certification of Lead Concentration in Standard Reference Materials by Isotope Dilution Mass Spectrometry

1982 ◽  
Vol 65 (4) ◽  
pp. 953-956
Author(s):  
I Lynus Barnes ◽  
Thomas J Murphy ◽  
Eddy A I Michiels
Keyword(s):  
Mass Spectrometry ◽  
Reference Materials ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Bovine Liver ◽  
Standard Reference Materials ◽  
Oyster Tissue ◽  
Human Environment ◽  
Advantages And Disadvantages ◽  
Definitive Method

Abstract In response to needs for analytical standards by researchers studying the exposure of humans to lead, a wide variety of environmental and “food” Standard Reference Materials have been prepared and certified for lead as well as for many other elements. Among the food types are SRM1571, Orchard Leaves, 45 ppm; SRM 1575, Pine Needles, 10.8 ppm; SRM 1573, Tomato Leaves, 6.3 ppm; SRM 1566, Oyster Tissue, 0.48 ppm; SRM 1577, Bovine Liver, 0.34 ppm; SRM 1568, Rice Flour, 0.045 ppm; and SRM 1567, Wheat Flour, 0.020 ppm. These materials, intended for use in calibrating instruments and methods, have been certified by a definitive method, isotope dilution mass spectrometry. The advantages and disadvantages of this technique are discussed and some suggestions for the use of its isotopic selectivity in the study of lead in the human environment are presented.

scholarly journals Proposed Serum Cholesterol Reference Measurement Procedure by Gas Chromatography–Isotope Dilution Mass Spectrometry

2011 ◽  
Vol 57 (4) ◽  
pp. 614-622 ◽  
Author(s):  
Selvin H Edwards ◽  
Mary M Kimberly ◽  
Susan D Pyatt ◽  
Shelton L Stribling ◽  
Kara D Dobbin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Serum Cholesterol ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Measurement Procedure ◽  
Standard Reference Materials ◽  
Reference Measurement ◽  
Reference Measurement Procedure ◽  
The Mean

BACKGROUND Our purpose was to establish a mass spectrometry reference measurement procedure (RMP) for cholesterol to use in the CDC's standardization programs. We explored a gas chromatography–isotope dilution mass spectrometry (GC-IDMS) procedure using a multilevel standard calibration curve to quantify samples with varying cholesterol concentrations. METHODS We calibrated the mass spectrometry instrument by isotope dilution with a pure primary standard reference material and an isotopically enriched cholesterol analog as the internal standard (IS). We diluted the serum samples with Tris-HCl buffer (pH 7.4, 0.05 mol/L, 0.25% Triton X-100) before analysis. We used 17 serum pools, 10 native samples, and 2 standard reference materials (SRMs). We compared the GC-IDMS measurements with the CDC's modified Abell–Levy–Brodie–Kendall (AK) RMP measurements and assessed method accuracy by analyzing 2 SRMs. We evaluated the procedure for lack of interference by analyzing serum spiked with a mixture of 7 sterols. RESULTS The mean percent bias between the AK and the GC-IDMS RMP was 1.6% for all samples examined. The mean percent bias from NIST's RMP was 0.5% for the SRMs. The total %CVs for SRM 1951b levels I and II were 0.61 and 0.73%, respectively. We found that none of the sterols investigated interfered with the cholesterol measurement. CONCLUSIONS The low imprecision, linear response, lack of interferences, and acceptable bias vs the NIST primary RMP qualifies this procedure as an RMP for determining serum cholesterol. The CDC will adopt and implement this GC-IDMS procedure for cholesterol standardization.

A Method for the Routine Determination of Methylmercury in Marine Tissue by GC Isotope Dilution-ICP-MS

2012 ◽  
Vol 95 (4) ◽  
pp. 1189-1194 ◽  
Author(s):  
Stig Valdersnes ◽  
Amund Maage ◽  
Daniel Fliegel ◽  
Kåre Julshamn
Keyword(s):  
Reference Material ◽  
Reference Materials ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Standard Reference Materials ◽  
Statistical Measures ◽  
Icp Ms ◽  
Wide Range ◽  
Z Scores

Abstract Currently, there is no legal limit for methyl mercury (MeHg) in food; thus, no standardized method for the determination of MeHg in seafood exists within the European jurisdiction. In anticipation of a future legislative limit an inductively coupled plasma isotope dilution mass spectrometry (GC-ICP-ID-MS) method was developed in collaboration with the European Standardization Organization (CEN). The method comprises spiking the tissue sample with Me201Hg, followed by decomposition with tetramethylammonium hydroxide, pH adjustment and derivatization with sodium tetraethylborate, and finally organic extraction of the derivatized MeHg in a hexane phase. Subsequently, the sample is analyzed via GC-ICP-MS and the result calculated using the ID equation. The working range of the method was 0.0005–1.321 mg/kg MeHg in marine tissue, with an internal reproducibility (RSD) of 12–1%. The method was validated based on statistical measures, such as the z-scores, using the commercially available reference materials from National Institute of Standards and Technology Standard Reference Material (NIST SRM) 1566b, NIST SRM 2977 and National Research Council of Canada (NRCC) TORT 2, NRCC, DORM 3, NRCC DOLT 4, and European Reference Material (ERM) CE 464. Z-scores for all standard reference materials, except for NIST SRM 1566b, were better than |1.5|. The wide range of marine tissues used during the validation ensures that the method will be applicable for measuring of MeHg in seafood matrixes of all kinds.

Matrix effects in Pb/U measurements during LA-ICP-MS analysis of the mineral apatite

2016 ◽  
Vol 31 (6) ◽  
pp. 1206-1215 ◽  
Author(s):  
Jay Thompson ◽  
Sebastien Meffre ◽  
Roland Maas ◽  
Vadim Kamenetsky ◽  
Maya Kamenetsky ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Reference Materials ◽  
Isotope Dilution ◽  
Matrix Effects ◽  
Primary Standard ◽  
Isotope Dilution Mass Spectrometry ◽  
Ms Analysis ◽  
Icp Ms

U–Pb ages of several apatite reference materials, acquired by LA-ICP-MS over a 3.5 year period using the Otter Lake apatite as a primary standard, show systematic offsets (up to 3%) from reference ages obtained by isotope dilution mass spectrometry.

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