Measles virus-specific immunoglobulin D antibody in cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitis and multiple sclerosis

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.

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Diagnosis of Subacute Sclerosing Panencephalitis by a Simple Spinal Fluid Gel Precipitation Test for Measles

PEDIATRICS ◽

10.1542/peds.49.1.133 ◽

1972 ◽

Vol 49 (1) ◽

pp. 133-136

Author(s):

Dale E. Dietzman ◽

Luiz Horta-Barbosa ◽

Helen M. Krebs ◽

David L. Madden ◽

David A. Fuccillo ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Hemagglutination Inhibition ◽

Measles Virus ◽

Complement Fixation ◽

Subacute Sclerosing Panencephalitis ◽

Double Diffusion ◽

Virus Antigen ◽

Spinal Fluid ◽

Reliable Procedure ◽

Precipitation Test

A double-diffusion gel precipitation test is described which provides an easy, rapid, and reliable procedure for assistance in the diagnosis of subacute sclerosing penencephalitis by detecting measles antibody in concentrated cerebrospinal fluid. The test is based on the precipitation of rubeola antibodies with a high titered SSPE measles-virus antigen. The sensitivity of the test is comparable to the sensitivity of rubeola complement-fixation and hemagglutination-inhibition determinations on unconcentrated spiral fluid. The method could be available to hospitals or institutions if the antigen were prepared commercially or by a national center.

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Subacute Sclerosing Panencephalitis

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v37i4.43352 ◽

2019 ◽

Vol 37 (4) ◽

pp. 205-208

Author(s):

Gobinda Chandra Banik ◽

Sakib Aman ◽

Farhana Sultana ◽

Syed Mohammad Arif

Keyword(s):

Cerebrospinal Fluid ◽

Virus Infection ◽

Antibody Titer ◽

Measles Virus ◽

Subacute Sclerosing Panencephalitis ◽

Abnormal Behavior ◽

Short History ◽

Altered Consciousness ◽

History Of ◽

Metachromatic Leucodystrophy

Subacute sclerosing panencephalitis (SSPE) is chronic progressive encephalitis of childhood and young adoloscent due to persistent measles virus infection. This case illustrates a 14 year old girl presented with short history of intellectual decline, abnormal behavior, myoclonus and altered consciousness with suggestive neuroimaging mimicking metachromatic leucodystrophy. Subsequently she was diagnosed to be a case of Subacute sclerosing panencephalitis (SSPE) on the basis of Electroencephalography (EEG) and Cerebrospinal fluid(CSF) measles antibody titer. J Bangladesh Coll Phys Surg 2019; 37(4): 205-208

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